Article
Biochemistry & Molecular Biology
Himanshu K. Mishra, Noelle M. Ying, Angelica Luis, Heather Wei, Metta Nguyen, Timothy Nakhla, Sara Vandenburgh, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark A. Frye, Fred H. Gage, Elliot S. Gershon, Melvin G. McInnis, Caroline M. Nievergelt, John I. Nurnberger, Paul D. Shilling, Ketil J. Oedegaard, Peter P. Zandi, R. Kelsoe John, David K. Welsh, Michael J. McCarthy
Summary: Neuronal circadian rhythm abnormalities are present in patients with bipolar disorder, with the most pronounced deficits observed in individuals who do not respond to lithium treatment. Stimulation of entrainment pathways may partly reverse these rhythm deficits.
MOLECULAR PSYCHIATRY
(2021)
Review
Neurosciences
Kayla E. Rohr, Michael J. McCarthy
Summary: Studies have shown that lithium affects cellular circadian rhythms and increases morningness behaviors in bipolar disorder (BD) patients, which may contribute to its therapeutic effects. However, current evidence is limited and further research is needed to understand the exact mechanisms behind lithium's effects on circadian rhythms and the longitudinal changes in circadian rhythms in BD patients.
NEUROSCIENCE LETTERS
(2022)
Article
Medicine, General & Internal
Eve Reynaud, Fabrice Berna, Emmanuel Haffen, Luisa Weiner, Julia Maruani, Michel Lejoyeux, Carmen M. Schroder, Patrice Bourgin, Pierre A. Geoffroy
Summary: The study confirmed the validity of the French version of the SPAQ, which has a two-factor structure. Mood and social activity were significantly affected by seasons in the depressed/bipolar group, and a stronger seasonal score was associated with more severe phenotypes of depression and mania.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Pierre A. Geoffroy, Laura Palagini
Summary: Depressive syndromes are common brain conditions with sleep complaints in over 90% of patients, and using chronotherapeutics such as light therapy and sleep deprivation can effectively treat depression. It is important to combine chronotherapeutics with behavioral measures to ensure healthy sleep.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Melissa E. S. Richardson, Desiree Brown, Danielle Honore, Andisa Labossiere
Summary: This study showed that fragmenting the night period and distributing it across the 24-hour day resulted in lengthening of circadian rhythm in mice, leading to reduced anxiety and anhedonia behaviors. However, these effects were reversible after exposure to the fragmented night cycle for a period of time.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Himanshu K. Mishra, Heather Wei, Kayla E. Rohr, Insu Ko, Caroline M. Nievergelt, Adam X. Maihofer, Paul D. Shilling, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark Frye, Fred Gage, Elliot Gershon, Melvin G. McInnis, John Nurnberger, Ketil J. Oedegaard, Peter P. Zandi, John R. Kelsoe, Michael J. McCarthy
Summary: Bipolar disorder (BD) is characterized by mood episodes, disrupted circadian rhythms, and gray matter reduction in the brain. Lithium, an effective pharmacotherapy for BD, has neuroprotective properties and beneficial effects on circadian rhythms that may distinguish lithium responders (Li-R) from non-responders (Li-NR). Patterns of co-expression among circadian clock and cell survival genes were found in BD patients and controls, as well as in Li-R vs. Li-NR cells. The coordination between circadian clock and cell survival genes in BD may help predict lithium response.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Ni Xu, Kiyomi Shinohara, Kate E. A. Saunders, John R. Geddes, Andrea Cipriani
Summary: This study found a potential association between lithium and shifts towards morningness, suggesting insufficient evidence for the effect of lithium on circadian rhythm. Chronotype may be a potential target for further exploration of biomarkers in lithium treatment for patients with bipolar disorder. Further prospective and longitudinal studies using actigraphy to monitor daily circadian rest-activity changes are needed.
Article
Behavioral Sciences
Joanne S. Carpenter, Jacob J. Crouse, Elizabeth M. Scott, Sharon L. Naismith, Chloe Wilson, Jan Scott, Kathleen R. Merikangas, Ian B. Hickie
Summary: Major mood syndromes are common and disabling mental disorders, with a lack of clear delineation of underlying pathophysiological mechanisms hindering prevention and treatment. Dysfunction of the 24-h circadian system is a potential mechanism linked to mood syndromes. 'Circadian depression' is proposed as a new clinical phenotype with disrupted 24-h sleep-wake cycles, reduced motor activity, low subjective energy, and weight gain as key characteristics. Early onset, bipolarity features, poor response to traditional antidepressants, and concurrent cardiometabolic and inflammatory issues are part of the illness course associated with this phenotype. Identifying and targeting circadian disturbances in mood syndromes may offer valuable clinical insights for effective treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Bruno Etain, Manon Meyrel, Vincent Hennion, Frank Bellivier, Jan Scott
Summary: The study found that actigraphy parameters were associated with response to lithium treatment and could correctly classify BD cases. The model was robust in BD-I patients but not in BD-II patients. Despite limitations, the findings support the use of actigraphy for real-time monitoring of lithium response.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Priyanka Panchal, Gabriela de Queiroz Campos, Danielle A. Goldman, Randy P. Auerbach, Kathleen R. Merikangas, Holly A. Swartz, Anjali Sankar, Hilary P. Blumberg
Summary: The systematic review highlighted the differences in sleep quality, daily activity, and activity patterns in individuals with bipolar disorder compared to the general population. Additionally, the stabilizing effect of therapeutic options on activity patterns was supported by the literature.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Lisa Ferrand, Vincent Hennion, Ophelia Godin, Frank Bellivier, Jan Scott, Bruno Etain
Summary: Disturbances in sleep-wake cycles and circadian rhythms may be valuable predictors of recurrence in bipolar disorder. The amplitude and variability/stability of circadian rhythms measured by actigraphy could serve as valid markers for future recurrences and potential targets for interventions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Huirong Luo, Xueqian Wang, Yinlin Zhang, Junyao Li, Renqin Hu, Zheng Zhang, Qian Liao, Xiaoxin Zhou, Wei Deng, Jian Yang, Qinghua Luo
Summary: This longitudinal cohort study aims to investigate whether circadian rhythm can predict changes in neurocognitive functioning over time in patients with bipolar disorder (BD). The study will recruit 100 BD patients in either depressive or remitted states and evaluate them clinically, from a circadian rhythm perspective, and neurocognitively at baseline, 6-month, and 12-month follow-ups. The study will examine both cross-sectional and longitudinal associations between participants' circadian rhythm patterns and neurocognitive functioning using statistical analyses.
ANNALS OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xitong Liang, Timothy E. Holy, Paul H. Taghert
Summary: The molecular clocks in Drosophila regulate internal and external calcium fluxes, generating two rhythmical patterns in basal calcium levels and fast calcium fluctuations. These rhythms are essential for circadian pacemaker neurons and provide rhythmic outputs to regulate downstream brain activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Qin Zhou, Kankan Wang, Jiameng Qiu, Di Zhu, Tian Tian, Yunfei Zhang, Ximing Qin
Summary: Bipolar disorder is a psychiatric disorder characterized by alternate episodes of mania and depression. Studies have found that lithium salt can upregulate the expression of the clock gene Per2 by reducing the expression of the transcription factor E4BP4. This provides a new therapeutic target and approach for treating BPD.
Article
Cell & Tissue Engineering
Krishna C. Vadodaria, Ana P. D. Mendes, Arianna Mei, Vipula Racha, Galina Erikson, Maxim N. Shokhirev, Ruth Oefner, Kelly J. Heard, Michael J. McCarthy, Lisa Eyler, John R. Kelsoe, Renata Santos, Maria C. Marchetto, Fred H. Gage
Summary: Studies suggest that bipolar disorder (BD) patients have altered glial populations in the brain and a pro-inflammatory state peripherally. Focusing on astrocytes derived from induced pluripotent stem cells (iPSCs) of BD patients, researchers found that they exhibit changes in gene expression and reduced neuronal activity, partly mediated by IL-6. The findings highlight the potential role of astrocyte-mediated inflammation signaling in BD neuropathology.
Article
Clinical Neurology
Yian Lin, Adam X. Maihofer, Emma Stapp, Megan Ritchey, Ney Alliey-Rodriguez, Amit Anand, Yokesh Balaraman, Wade H. Berrettini, Holli Bertram, Abesh Bhattacharjee, Cynthia V. Calkin, Carla Conroy, William Coryell, Nicole D'Arcangelo, Anna DeModena, Joanna M. Biernacka, Carrie Fisher, Nicole Frazier, Mark Frye, Keming Gao, Julie Garnham, Elliot Gershon, Kara Glazer, Fernando S. Goes, Toyomi Goto, Elizabeth Karberg, Gloria Harrington, Petter Jakobsen, Masoud Kamali, Marisa Kelly, Susan G. Leckband, Falk W. Lohoff, Andrea Stautland, Michael J. McCarthy, Melvin G. McInnis, Francis Mondimore, Gunnar Morken, John I. Nurnberger, Ketil J. Oedegaard, Vigdis Elin Giever Syrstad, Kelly Ryan, Martha Schinagle, Helle Schoeyen, Ole A. Andreassen, Marth Shaw, Paul D. Shilling, Claire Slaney, Bruce Tarwater, Joseph R. Calabrese, Martin Alda, Caroline M. Nievergelt, Peter P. Zandi, John R. Kelsoe
Summary: The study aimed to identify predictors of lithium response in bipolar disorder, and found several clinical features associated with failure to respond to lithium. More research is needed to confirm these clinical predictors of treatment failure and to determine their clinical utility in differentiating who will respond well to lithium before starting pharmacotherapy.
Review
Clinical Neurology
Michael J. McCarthy, John F. Gottlieb, Robert Gonzalez, Colleen A. McClung, Lauren B. Alloy, Sean Cain, Davide Dulcis, Bruno Etain, Benicio N. Frey, Corrado Garbazza, Kyle D. Ketchesin, Dominic Landgraf, Heon-Jeong Lee, Cynthia Marie-Claire, Robin Nusslock, Alessandra Porcu, Richard Porter, Philipp Ritter, Jan Scott, Daniel Smith, Holly A. Swartz, Greg Murray
Summary: Symptoms of bipolar disorder include changes in mood, activity, energy, sleep, and appetite, with circadian rhythm disturbance considered a biological feature underlying BD. Research has found associations between the circadian system and mood regulation, but circadian disruption is not specific to BD and is present across various psychiatric disorders. Future studies on circadian rhythms and its role in BD should carefully define associations and integrate across levels of analysis for more comprehensive insights.
Article
Clinical Neurology
Monica Federoff, Michael J. McCarthy, Amit Anand, Wade H. Berrettini, Holli Bertram, Abesh Bhattacharjee, Cynthia Calkin, Carla Conroy, William H. Coryell, Nicole D'Arcangelo, Anna DeModena, Carrie Fisher, Scott Feeder, Nicole Frazier, Mark A. Frye, Keming Gao, Julie Garnham, Elliot S. Gershon, Ney Alliey-Rodriguez, Kara Glazer, Fernando Goes, Toyomi Karberg, Gloria Harrington, Petter Jakobsen, Masoud Kamali, Marisa Kelly, Susan G. Leckband, Falk Lohoff, Adam X. Maihofer, Melvin G. McInnis, Francis Mondimore, Gunnar Morken, John Nurnberger, Ketil J. Oedegaard, Megan Ritchey, Kelly Ryan, Martha Schinagle, Helle Schoeyen, Candice Schwebel, Martha Shaw, Paul D. Shilling, Claire Slaney, Andrea Stautland, Bruce Tarwater, Joseph R. Calabrese, Martin Alda, Caroline M. Nievergelt, Peter P. Zandi, John R. Kelsoe
Summary: Exposure to lithium is associated with reduced circadian disruption, and lithium response at 12 weeks was selectively associated with the reduction of circadian depressive symptoms.
Article
Psychiatry
Micah Cearns, Azmeraw T. Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond De Paulo, Bruno Etain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi Hsiang Hsu, Stephane Jamain, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Konig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nothen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Scott R. Clark, Bernhard T. Baune
Summary: This study utilized a combination of genetic and clinical factors to predict lithium response in patients with bipolar disorder. By stratifying patients genetically and training machine-learning models with clinical predictors, significant improvements in lithium response prediction were achieved.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Stephen Beesley, Thomas Sullenberger, Christopher Lee, Sanjay S. Kumar
Summary: This study investigates the contribution of glutamatergic NMDAR subunit GluN3A to the pathology and pathophysiology of temporal lobe epilepsy, and reveals its correlation with neuronal loss and neurodegeneration. The findings shed light on the underlying mechanism of temporal lobe epilepsy and have significant implications.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Review
Neurosciences
Kayla E. Rohr, Michael J. McCarthy
Summary: Studies have shown that lithium affects cellular circadian rhythms and increases morningness behaviors in bipolar disorder (BD) patients, which may contribute to its therapeutic effects. However, current evidence is limited and further research is needed to understand the exact mechanisms behind lithium's effects on circadian rhythms and the longitudinal changes in circadian rhythms in BD patients.
NEUROSCIENCE LETTERS
(2022)
Biographical-Item
Neurosciences
Michael J. J. McCarthy, Maria Hadjiconstantinou
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Himanshu K. Mishra, Atulya D. Mandyam, Wulfran Trenet, Heather Wei, Caroline M. Nievergelt, Adam X. Maihofer, Paul D. Shilling, Martin Alda, Elliot Gershon, John R. Kelsoe, Michael J. McCarthy, Melvin G. McInnis
Summary: Bipolar disorder (BD) is a psychiatric illness characterized by manic and depressive episodes. Lithium is commonly used as a treatment, but only a subset of patients respond to it. This study examined the effects of METH on neuronal cells derived from lithium responder (Li-R) and nonresponder (Li-NR) BD patients, as well as healthy controls. The results showed that Li-R cells were less vulnerable to METH-induced cell death compared to Li-NR cells and controls. Additionally, pre-treatment with a dopamine receptor antagonist reversed the neurotoxic effects of METH. These findings suggest that dopamine signaling and lithium response may play a role in the pathophysiology of BD.
Article
Psychiatry
Michael J. Mccarthy, Ty Brumback, Michael L. Thomas, Alejandro D. Meruelo
Summary: This study analyzed a sample of high-risk adolescents and found associations between chronotype, stressful life events, and impulsivity. Increased eveningness was associated with a higher number of stressful life events and increased impulsivity.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Meeting Abstract
Neurosciences
Michael McCarthy, Connor McCabe, Alejandro Meruelo
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Kayla Rohr, Michael McCarthy
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Rizaldy C. Zapata, Allison Silver, Dongmin Yoon, Besma Chaudry, Avraham Libster, Michael J. McCarthy, Olivia Osborn
Summary: This study investigates the interaction between antipsychotic drugs (AP), circadian rhythms, and metabolic side-effects. Through experiments on mice and observations on humans, it is found that the timing of AP dosing has a significant impact on the development of metabolic side-effects. Additionally, time restricted feeding (TRF) is identified as a potential intervention to mitigate AP-induced metabolic side-effects. These findings provide insight into methods for reducing metabolic side-effects associated with AP.
Meeting Abstract
Neurosciences
Neal Swerdlow, Yash Joshi, Juan Molina, Michael McCarthy
BIOLOGICAL PSYCHIATRY
(2022)
Article
Immunology
Michael J. Mccarthy
Summary: This article reviews ME/CFS from the perspective of circadian rhythms, focusing on the disrupted TGFB signaling that may play a role in disrupting physiological rhythms in sleep, activity, and cognition associated with ME/CFS. Advances in chronobiology and biomarker research justify renewed interest in circadian rhythm research in ME/CFS, especially in the context of the COVID-19 pandemic.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.