Article
Neurosciences
Hae Young Shin, Min Jung Kwon, Eun Mi Lee, Kyung Kim, Young Joo Oh, Hyung Soon Kim, Dong Hoon Hwang, Byung Gon Kim
Summary: The Myc proto-oncogene acts as a transcriptional hub gene in regulating the expression of a distinct subset of regeneration-associated genes (RAGs) in DRGs following preconditioning nerve injury. Deletion of Myc leads to a decrease in injury-induced expression of a specific subset of RAGs, which overlaps with the list of RAGs upregulated by Myc overexpression. Myc overexpression in DRGs post-spinal cord injury prevents sensory axon retraction through downstream RAG June, highlighting the critical role of Myc in axon regeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Lingtai Yu, Mengfan Liu, Fuxiang Li, Qianghua Wang, Meizhi Wang, Kwok-Fai So, Yibo Qu, Libing Zhou
Summary: Celsr2 knockout improves the survival and axon regeneration of injured motoneurons by alleviating inhibitory synaptic stripping.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Antonio Cadiz Diaz, Natalie A. Schmidt, Mamiko Yamazaki, Chia-Jung Hsieh, Thomas S. Lisse, Sandra Rieger
Summary: Tissue wounding induces axon regeneration through distinct mechanisms involving both neurons and keratinocytes, mediated by H2O2 signaling and matrix remodeling. These processes are essential for the regeneration of cutaneous axons after injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Neurosciences
Nicole Y. Tsai, Derek S. Welsbie, Xin Duan
Summary: In this issue, three studies present new strategies for uncovering mediators of retinal neuroprotection and optic nerve regeneration, including transcriptional regulators and molecular targets.
Article
Biology
Victoria L. Czech, Lauren C. O'Connor, Brendan Philippon, Emily Norman, Alexandra B. Byrne
Summary: TIR-1/dSarm/SARM1, a key regulator of axon degeneration, inhibits axon regeneration while promoting axon degeneration by interacting with different MAP kinase pathways. This mechanism is conserved in human SARM1. These findings provide critical insight into the multidimensional regulation of axon injury response and may inform strategies for repair.
Article
Neurosciences
Lindsay H. Teliska, Irene Dalla Costa, Ozlem Sert, Jeffery L. Twiss, Matthew N. Rasband
Summary: This study demonstrates the importance of an intact axon initial segment (AIS) for efficient axon regeneration and functional recovery of multipolar motor neurons after nerve injury. Loss of AIS may impair the delivery of axonal proteins, mRNA, and other necessary cargoes for regeneration. Therapeutic strategies for axon regeneration should consider preserving or reassembling the AIS.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Sean Mccracken, Michael J. Fitzpatrick, Allison L. Hall, Zelun Wang, Daniel Kerschensteiner, Josh L. Morgan, Philip R. Williams
Summary: Retinal ganglion cell (RGC) degeneration, caused by axon degeneration, is the main reason for vision loss in blinding conditions. Axonal Ca2+ elevations from optic nerve injury do not reach RGC somas, and baseline Ca2+ levels of RGCs predict their survival after axon injury.
Article
Medicine, Research & Experimental
Min Jung Kwon, Yeojin Seo, Hana Cho, Hyung Soon Kim, Young Joo Oh, Simay Geniscan, Minjae Kim, Hee Hwan Park, Eun-Hye Joe, Myung-Hee Kwon, Han Chang Kang, Byung Gon Kim
Summary: Preconditioning nerve injury can enhance axonal regeneration of DRG neurons by activating pro-regenerative perineuronal macrophages. This study reveals that oncomodulin (ONCM) produced from regeneration-associated macrophages strongly influences the regeneration of DRG sensory axons. Delivery of ONCM using a nanogel system can promote sensory axon regeneration following spinal cord injury.
Article
Multidisciplinary Sciences
Alexander M. Hilla, Annemarie Baehr, Marco Leibinger, Anastasia Andreadaki, Dietmar Fischer
Summary: Regenerative failure in the optic nerve is attributed to a chemoattractive CXCL12/CXCR4-dependent mechanism that prevents growth-stimulated axons from regenerating distally. Depletion of CXCR4 or CXCL12 reduces aberrant axonal growth and enables long-distance regeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Veselina Petrova, Bart Nieuwenhuis, James W. Fawcett, Richard Eva
Summary: The research focuses on utilizing various axonal organelles to promote regeneration in the injured adult CNS, highlighting their importance in developmental axon growth and discussing how they can be targeted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Kadidia Pemba Adula, Matthew Shorey, Vasudha Chauhan, Khaled Nassman, Shu-Fan Chen, Melissa M. Rolls, Alvaro Sagasti
Summary: DLK and LZK play different roles in zebrafish, promoting axon regeneration in motor neurons while inhibiting excessive growth in sensory neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Tatsuhiro Shimizu, Kayoko Sugiura, Yoshiki Sakai, Abdul R. Dar, Rebecca A. Butcher, Kunihiro Matsumoto, Naoki Hisamoto
Summary: Chemical communication plays a crucial role in axon regeneration, and the ascaroside signaling system serves as a unique example of regulating the regenerative pathway in the nervous system.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Cell Biology
Gilberto Gonzalez, Lizhen Chen
Summary: This review summarizes the inhibitory role of EFA6 on axon regeneration through regulating microtubule dynamics and affecting ARF6 (ADP-ribosylation factor 6) GTPase-mediated integrin transport, highlighting its potential as a promising therapeutic strategy to promote axon regeneration and functional recovery after axon injury.
Review
Biochemistry & Molecular Biology
Simeon C. Daeschler, Konstantin Feinberg, Leila Harhaus, Ulrich Kneser, Tessa Gordon, Gregory H. Borschel, Aleksey Zaitsev
Summary: Peripheral nerve injuries have significant impacts on individuals and society, resulting in functional impairments, lengthy rehabilitation, and socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug with neuroregenerative properties, shows promise in accelerating nerve fiber regeneration. This review explores the therapeutic potential of tacrolimus through investigating its mechanisms of action and discussing practical barriers for clinical translation, providing insights into its translational perspectives as an adjunct therapy for nerve regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Adam J. Isabella, Jason A. Stonick, Julien Dubrulle, Cecilia B. Moens
Summary: Regeneration after peripheral nerve damage requires axons to grow to correct target tissues in a process called target-specific regeneration. Research on zebrafish vagus motor nerve reveals strong target-specific regrowth capabilities, with regeneration relying on neurons' intrinsic memory of their position and pre-existing innervation.
