Article
Biochemistry & Molecular Biology
Wencai Qiu, Xiuyan Ding, Shitao Li, Yongming He, Liqian Zhu
Summary: The study demonstrates that BoHV-1 has oncolytic effects against human lung adenocarcinoma in vivo. BoHV-1 infection reduced HDAC protein levels in A549 cells and showed synergy with the HDAC inhibitor TSA. In the mouse xenograft model, BoHV-1 effectively infected tumors and suppressed tumor growth, potentially through interaction with HDACs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mohamed A. Hamid, M. Tarek Moustafa, Sonali Nashine, Rodrigo Donato Costa, Kevin Schneider, Shari R. Atilano, Baruch D. Kuppermann, M. Cristina Kenney
Summary: Our study indicates that anti-VEGF drugs can affect the expression of genes related to oxidative stress, inflammation, and apoptosis, while TSA-induced deacetylation can alter transcription of genes involved in angiogenesis, apoptosis, and inflammation.
Article
Plant Sciences
Isabel Valero-Rubira, Ana Maria Castillo, Maria Angela Burrell, Maria Pilar Valles
Summary: Reprogramming microspores development towards embryogenesis through stress treatment is crucial for doubled haploid production. This study investigates the epigenetic dynamics and expression of genes associated with histone post-translational modifications (PTMs) and microspore embryogenesis (ME) induction in bread wheat cultivars. The results reveal that the induction efficiency of ME is related to the epigenetic state and expression of genes involved in pollen development, auxin signaling, and hormone signaling pathways. This breakthrough study provides insights into the molecular mechanisms governing ME induction efficiency in recalcitrant wheat genotypes and other crops.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Sharmin Hossain, Zhenhua Liu, Richard J. Wood
Summary: The study found that colon cancer cells respond differently to dietary components under different conditions. The effects of vitamin D and SFN on gene expression in colorectal cancer are selective and gene-specific.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Liguo Zhang, Yang Zhang, Yu Chen, Omid Gholamalamdari, Yuchuan Wang, Jian Ma, Andrew S. Belmont
Summary: The study shows that gene distance to nuclear speckles is a better predictor of gene expression levels than radial positioning. While only a small portion of the genome exhibits significant shifts in relative nuclear speckle distances between human cell lines, these changes are closely linked to cell type-specific gene expression.
Review
Biochemistry & Molecular Biology
Jacob King, Maya Patel, Sriram Chandrasekaran
Summary: Histone deacetylases (HDACs) are epigenetic enzymes that regulate gene expression and are influenced by cellular metabolism. The crosstalk between metabolism and histone acetylation impacts various biological processes. The use of systems biology methods can help uncover the interactions between metabolism, HDACs, and HDAC inhibitors, leading to the identification of potential biomarkers and therapeutic targets.
Article
Multidisciplinary Sciences
Seongjun Byun, Chan Hyeong Lee, Hyeongmin Jeong, Hyejin Kim, Hyug Moo Kwon, Sungho Park, Kyungjae Myung, Jungeun An, Myunggon Ko
Summary: TET proteins are identified as important epigenetic suppressors of beta 3-adrenergic receptor (beta-AR) expression in adipocytes, attenuating the responsiveness to beta-adrenergic stimulation. Deletion of all three Tet genes enhances the downstream beta-adrenergic responses, including lipolysis, thermogenic gene induction, oxidative metabolism, and fat browning. Targeting the TET-histone deacetylase-beta 3-AR axis may be a potential therapeutic approach for obesity and related metabolic diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Shaobo Wang, Min Song, Bo Zhang
Summary: This study demonstrated that pretreatment with TSA could enhance radiation-induced DNA damage in esophageal cancer cells, potentially through inducing cell cycle arrest and increasing cell apoptosis. The altered histone modification of the whole genome may contribute to this radiosensitizing effect.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Plant Sciences
Risaku Hirai, Shumin Wang, Taku Demura, Misato Ohtani
Summary: This study identifies histone deacetylase (HDAC) inhibitors as regulators of xylem vessel cell differentiation, affecting gene expression and the formation of the negative regulator complex OFP1/4-MYB75-KNAT7-BLH6. The findings suggest that active regulation of histone deacetylation by HDACs plays a role in xylem vessel cell differentiation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Lin Shen, Yanyan Li, Na Li, Liangfang Shen, Zhanzhan Li
Summary: This study explores the role of Histone deacetylases (HDAC) genes in low-grade glioma. Through clustering and modeling, the study establishes a prognostic model based on HDAC genes and identifies two molecular subtypes in low-grade glioma. The study also reveals the association between HDAC genes and clinical characteristics, tumor microenvironment, and immune infiltration levels. Additionally, the study identifies potential small molecular compounds for treatment in low-grade glioma patients. Overall, HDAC genes play an important role in low-grade glioma and offer potential prognostic and therapeutic targets.
Article
Food Science & Technology
Yao Liu, Ling Li, Yuanmiao Wei, Hanyue Zhang, Shuna Xiang, Ying Shang
Summary: The article introduces a detection method for T. albuminosus mushrooms using the TSA gene as an endogenous reference gene. The method is validated through qualitative and quantitative PCR, providing a fast and accurate way to detect T. albuminosus and protect consumers' rights while promoting the industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Cell Biology
Pil-Soo Jeong, Hae-Jun Yang, Soo-Hyun Park, Min Ah Gwon, Ye Eun Joo, Min Ju Kim, Hyo-Gu Kang, Sanghoon Lee, Young-Ho Park, Bong-Seok Song, Sun-Uk Kim, Deog-Bon Koo, Bo-Woong Sim
Summary: Combining chaetocin and TSA can enhance development and maturation rates of porcine SCNT embryos by improving epigenetic reprogramming. The synergistic effect of the combined treatment is more effective in promoting blastocyst development compared to using chaetocin or TSA alone.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Matthew J. Kling, Varun Kesherwani, Nitish K. Mishra, Gracey Alexander, Erin M. McIntyre, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter, Nagendra K. Chaturvedi
Summary: This study suggests that dual-inhibition of BET and HDAC proteins may be a novel therapeutic approach for MYC-driven MB.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Nutrition & Dietetics
Ghodratollah Nowrasteh, Afshin Zand, Laszlo Bence Raposa, Laszlo Szabo, Andras Tomesz, Richard Molnar, Istvan Kiss, Zsuzsa Orsos, Gellert Gerencser, Zoltan Gyongyi, Timea Varjas
Summary: Recently, there has been a lot of research on the field of epigenetics in relation to nutrition. In this study, the gene expression patterns of histone deacetylases (HDACs) and DNA methyltransferases (DNMTs) were determined in mice who were fed a human-equivalent dose of fruit seed and peel extract for 28 days and then exposed to a carcinogen. The results showed that the extract reduced the expression of HDAC and DNMT genes induced by the carcinogen, suggesting its potential chemopreventive effects.
Article
Chemistry, Medicinal
Fei-Fei Yang, Ting Hu, Jian-Quan Liu, Xiao-Qian Yu, Li-Ying Ma
Summary: Bone marrow transplantation is an effective immunotherapy for hematologic cancer, but matching is often challenging. Aberrant expression of histone deacetylases (HDACs) is closely associated with the occurrence and development of hematologic cancer. Recent studies have shown that HDACs may play a critical role in initiating anti-cancer immune response or enhancing immunotherapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Jui-Sheng Wu, Mei-Han Kao, Hsin-Da Tsai, Wai-Mui Cheung, Jin-Jer Chen, Wei-Yi Ong, Grace Y. Sun, Teng-Nan Lin
MOLECULAR NEUROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Christabel Fung-Yih Ho, Claire Poh-Ee Bon, Yee-Kong Ng, Deron R. Herr, Jui-Sheng Wu, Teng-Nan Lin, Wei-Yi Ong
NEUROCHEMICAL RESEARCH
(2018)
Article
Immunology
Gilbert Aaron Lee, Teng-Nan Lin, Cheng-Yu Chen, Shin-Yi Mau, Wan-Zhen Huang, Yu-Chieh Kao, Ruo-Yu Ma, Nan-Shih Liao
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Food Science & Technology
Kuan-Hsun Wu, Chi-Tang Ho, Zhao-Feng Chen, Li-Ching Chen, Jacqueline Whang-Peng, Teng-Nan Lin, Yuan-Soon Ho
JOURNAL OF FOOD AND DRUG ANALYSIS
(2018)
Article
Integrative & Complementary Medicine
Kuan-Hsun Wu, Wen-Jui Lee, Tzu-Chun Cheng, Hui-Wen Chang, Li-Ching Chen, Chia-Chang Chen, Hsiu-Man Lien, Teng-Nan Lin, Yuan-Soon Ho
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Neurosciences
Mei-Han Kao, Jui-Sheng Wu, Wai-Mui Cheung, Jin-Jer Chen, Grace Y. Sun, Wei-Yi Ong, Deron R. Herr, Teng-Nan Lin
Summary: Research has shown that C. nutans extract can suppress inflammation and protect the brain from ischemic damage, making it a potential treatment for stroke patients.
NEUROMOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Hung-Lin Chen, Chia-Hui Lo, Chi-Chun Huang, Meng-Ping Lu, Po-Yuan Hu, Chang-Shan Chen, Di-Yen Chueh, Peilin Chen, Teng-Nan Lin, Yuan-Hsin Lo, Yu-Ping Hsiao, Daniel K. Hsu, Fu-Tong Liu
Summary: The study found that the expression of galectin-7 is reduced in skin lesions of psoriasis patients, and IL-17A and TNF-alpha suppress galectin-7 expression in human keratinocytes. Galectin-7 attenuates the production of inflammatory mediators by keratinocytes via the microRNA-146a/ERK pathway when cells are stimulated with IL-17A. Fluvastatin was identified as an inducer of galectin-7 expression and showed potential in reducing IL-6 and IL-8 production induced by IL-17A.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Neurosciences
Tung-Tai Kuo, Vicki Wang, Jui-Sheng Wu, Yuan-Hao Chen, Kuan-Yin Tseng
Summary: This study demonstrated that VPA treatment could ameliorate neurological deficits in rats after ischemic stroke, without significantly reducing infarct volume. The morphological changes in microglia induced by VPA were associated with the suppression of galectin-3 production.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Wei-Yi Ong, Deron R. Herr, Grace Y. Sun, Teng-Nan Lin
Summary: Recent studies on Clinacanthus nutans have shown its potential anti-inflammatory, anti-tumorigenic, and antiviral properties. The extraction of its leaves has yielded various C-glycosyl flavones, which have been studied for their anti-inflammatory effects. This review focuses on the effects of C. nutans extracts and its phytochemical components on inflammatory signaling pathways in the nervous system. The study highlights their role in targeting the TLR4-NF-kB pathway, antioxidant defense pathway, and PLA2-COX-2 pathway.
Article
Neurosciences
Wei-Yi Ong, Mei-Han Kao, Wai-Mui Cheung, Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Teng-Nan Lin
Summary: This study demonstrates that ET has a protective effect on brain infarction after stroke in rodent models, with its effect becoming evident as early as 1 day after administration. Both intracerebroventricular and systemic administration of ET are effective in reducing brain infarct volume.
NEUROMOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mei-Han Kao, Chien-Yu Huang, Wai-Mui Cheung, Yu-Ting Yan, Jin-Jer Chen, Yuan-Soon Ho, Chung Y. Hsu, Teng-Nan Lin
Summary: This study confirms the existence of a neuroprotective ATF3 -> CTMP signal cascade in the ischemic brain and suggests the therapeutic potential of both ATF3 overexpression and CTMP knockdown for stroke treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Akhlaq A. Farooqui, Tahira Farooqui, Grace Y. Sun, Teng-Nan Lin, Daniel B. L. Teh, Wei-Yi Ong
Summary: Although the underlying mechanism(s) of how oxidative stress and inflammation induced by COVID-19 contribute to thrombosis risk and severity is not fully understood, this review highlights the role of blood lipids, particularly sPLA(2)-IIA metabolites, in COVID-19-associated coagulopathy (CAC). Increased levels of sPLA(2)-IIA and its metabolites, such as arachidonic acid and lysophospholipids, have been observed in the serum of COVID-19 patients. These lipid mediators can induce pro-coagulation and vasoconstriction, as well as trigger clotting mechanisms like NETosis. The findings suggest that blood lipid analysis may provide insights into the pathogenesis of CAC in COVID-19.
Review
Physiology
Mei-Han Kao, Teng-Nan Lin
CHINESE JOURNAL OF PHYSIOLOGY
(2019)