期刊
NEUROLOGY
卷 87, 期 6, 页码 595-600出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000002950
关键词
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资金
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (NIH) [U01 AG024904]
- Department of Defense (DOD) ADNI [W81XWH-12-2-0012]
- NIH [P30 AG010129, K01 AG030514]
- Dana Foundation
- National Institute on Aging (NIA) [R01 AG19771]
- NIA [K01 AG049050]
- Alzheimer's Association New Investigator Research Grant
- Indiana University Health-Indiana University School of Medicine Strategic Research Initiative
- Indiana Clinical and Translational Science Institute
- [P30 AG10133]
Objective: We investigated type 2 diabetes mellitus (T2DM) as a risk factor for brain atrophy and glucose hypometabolism in older adults with or at risk of cognitive impairment. Methods: Participants with the T2DM were identified from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1/GO/2 cohorts). Analysis of covariance models were used to compare participants with and without T2DM, controlling for potential confounding factors. Results: Whole brain volume and whole brain [F-18]-fluorodeoxyglucose (FDG) uptake were significantly different as a function of T2DM status, independent of baseline clinical diagnosis. On post hoc analysis, a lower whole brain volume was seen in participants with both mild cognitive impairment (MCI) and T2DM (n = 76) compared with participants who had MCI but not T2DM (n=747; p=0.009). Similarly, mean FDG uptake in gray matter and white matter was lower in participants with both MCI and T2DM (n=72) than in participants with MCI without T2DM (n=719; p=0.04). Subsequent regional analysis revealed that the decreased FDG uptake in participants with both MCI and T2DM was mainly manifested in 3 brain regions: frontal lobe, sensory motor cortex, and striatum. Conclusions: T2DM may accelerate cognition deterioration in patients with MCI by affecting glucose metabolism and brain volume.
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