Article
Oncology
Joon Min Jung, Ye-Jee Kim, Sung Eun Chang, Mi Woo Lee, Chong Hyun Won, Woo Jin Lee
Summary: This study aimed to assess the cancer risks in patients with psoriasis and evaluate the impact of TNF-α inhibitor and IL-12/23 inhibitor therapy on these risks. The results showed that patients with psoriasis had a significantly higher overall cancer risk compared to the general population. TNF-α inhibitor therapy was associated with an increased risk of overall cancer and lymphoma, while IL-12/23 inhibitor therapy was not associated with an increased risk of any cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Geriatrics & Gerontology
Tianwang Guan, Yanting Jiang, Zehao Luo, Yinglan Liang, Manting Feng, Zhenxing Lu, Min Yi, Yintong Teng, Ruoyun Zhou, Liangjia Zeng, Kaiyi Chi, Caiwen Ou, Minsheng Chen
Summary: This study evaluated the risk of cardiovascular disease (CVD)-related death in older patients (over 65 years) with cancer. The results showed that older patients with breast, endometrium, vulva, prostate gland, penis and melanoma of the skin cancers had a higher risk of CVD-related death compared to primary neoplasm death. The risk of CVD-related death was also higher in older patients with cancer compared to the general older population. Long-term cardiovascular risk management is needed for older patients with cancer.
Article
Oncology
Xiwen Huang, Johnni Hansen, Pei-Chen Lee, Chia-Kai Wu, Noah Federman, Onyebuchi A. Arah, Chung-Yi Li, Jorn Olsen, Beate Ritz, Julia E. Heck
Summary: The study found that gestational diabetes in Denmark and type II and gestational diabetes in Taiwan were not associated with childhood cancer, while maternal type I diabetes in Denmark was associated with the risk of glioma and maternal diabetes in Taiwan was associated with an elevated risk of glioma and hepatoblastoma in offspring.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Jeffrey Shi Kai Chan, Pias Tang, Kenrick Ng, Edward Christopher Dee, Teddy Tai Loy Lee, Oscar Hou In Chou, Yan Hiu Athena Lee, Dawnie Ho Hei Lau, Tong Liu, Gary Tse
Summary: The study found that the cardiovascular risks associated with PD-1 inhibitors and chemo-immunotherapy may not be significantly different amongst patients with lung cancer. Cardiovascular events linked to either regimen were observed to be uncommon.
Article
Computer Science, Information Systems
Xuhang Chen, Zhe Fu, Zhiying Song, Lijing Yang, Ajeck M. Ndifon, Zhiwei Su, Zheng Liu, Shuo Gao
Summary: In this article, a smart human-environment interactive (HEI) environment is proposed to address the issue of user privacy leakage in ALS patients using assistive wearable technologies. The HEI environment utilizes eye motion detection, radio-frequency identification (RFID), and speech feedback techniques to interpret user intentions and perform desired operations on smart devices, achieving a high average accuracy of 93.2% while ensuring privacy protection.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Review
Oncology
Joyce K. Hwang, Tian Zhang, Andrew Z. Wang, Zihai Li
Summary: Within less than a year of the COVID-19 pandemic, ten vaccines for SARS-CoV-2 have been approved, with two mRNA-based vaccines showing promising results. Concerns arise about the safety and efficacy of these vaccines for cancer patients undergoing immunomodulatory treatments, but most cancer therapies should not hinder the generation of protective immunity. Additional research in this area is needed and it is recommended that the majority of cancer patients receive COVID vaccinations when possible.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Cell Biology
Yongqiang Zheng, Yan Huang, Xiwen Zheng, Jiangtong Peng, Ying Chen, Kaixu Yu, Yun Yang, Xi Wang, Xue Yang, Jiaxin Qian, Xindi Wang, Xiaolan Gao, Bian Wu
Summary: This study characterized the demographic characteristics and mortality rates of COPD deaths in cancer patients in the United States, finding a nearly two-fold increased risk compared to the general population. The proportion of cancer survivors dying from COPD increased over time, with lung cancer patients having the highest overall risk.
Article
Oncology
Paolo Contiero, Roberto Boffi, Alessandro Borgini, Sabrina Fabiano, Andrea Tittarelli, Michael Mian, Fabio Vittadello, Susi Epifani, Antonino Ardizzone, Claudia Cirilli, Lorenza Boschetti, Stefano Marguati, Giuseppe Cascone, Rosario Tumino, Anna Clara Fanetti, Paola Giumelli, Giuseppa Candela, Tiziana Scuderi, Maurizio Castelli, Salvatore Bongiorno, Giulio Barigelletti, Viviana Perotti, Chiara Veronese, Fabio Turazza, Marina Crivaro, Giovanna Tagliabue, MAPACA Working Grp
Summary: This study aimed to evaluate the mortality rates of breast cancer patients from different causes and analyze the differences based on age, stage, and registry area. The results showed that breast cancer was the leading cause of death, followed by cardiovascular disease. The study also revealed variations in cause-specific hazards based on age and stage.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Maurizio Grassano, Andrea Calvo, Cristina Moglia, Maura Brunetti, Marco Barberis, Luca Sbaiz, Antonio Canosa, Umberto Manera, Rosario Vasta, Lucia Corrado, Sandra D'Alfonso, Letizia Mazzini, Sonja W. Scholz, Clifton Dalgard, Jinhui Ding, Raphael J. Gibbs, Ruth Chia, Bryan J. Traynor, Adriano Chio
Summary: Our study assessed the burden of rare genetic variants and estimated the contribution of known ALS genes in an Italian population-based cohort through whole genome sequencing. We identified potential disease-causing variants in 11.9% of ALS patients and confirmed the strong association of rare variants in SOD1 with the disease. We also found that the contribution of rare variants in other known ALS genes to disease risk in our cohort is limited.
Article
Clinical Neurology
Maurizio Grassano, Andrea Calvo, Cristina Moglia, Luca Sbaiz, Maura Brunetti, Marco Barberis, Federico Casale, Umberto Manera, Rosario Vasta, Antonio Canosa, Sandra D'Alfonso, Lucia Corrado, Letizia Mazzini, Clifton Dalgard, Ramita Karra, Ruth Chia, Bryan Traynor, Adriano Chio
Summary: This study evaluated the diagnostic yield and advantages of whole-genome sequencing (WGS) as a standard diagnostic test for Amyotrophic Lateral Sclerosis (ALS). The results showed that WGS had a high diagnostic yield and lower cost compared to conventional strategies. It also identified differences in mutation rates between early-onset and late-onset ALS patients, and found additional genetic factors that worsen prognosis. Therefore, WGS should be considered as the standard genetic testing for all ALS patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Chengzhuo Li, Didi Han, Qiao Huang, Fengshuo Xu, Shuai Zheng, Xiang Li, Fanfan Zhao, Xiaojie Feng, Jun Lyu
Summary: The competing-risks model identified sex, tumor size, distant metastasis, surgery status, LNP, and LNR as independent prognostic factors for CSD in UTUC patients. The nomogram predicts the probability of CSD at 3, 5, and 8 years, aiding clinicians in predicting individual patient survival probabilities.
Article
Endocrinology & Metabolism
Mengdan Miao, Yanping Zhu, Lulu Wang, Yifei Miao, Rong Li, Huaijun Zhou
Summary: In this study, a nomogram predictive model was successfully established using data from 517 endometrial cancer patients, with 8 variables identified for predicting recurrence. The model showed good discriminative power and calibration in both training and validation cohorts, providing valuable assistance for clinicians in assessing recurrence in endometrial cancer patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Maurizio Grassano, Umberto Manera, Fabiola De Marchi, Paolo Cugnasco, Enrico Matteoni, Margherita Daviddi, Luca Solero, Alessandro Bombaci, Francesca Palumbo, Rosario Vasta, Antonio Canosa, Paolina Salamone, Giuseppe Fuda, Federico Casale, Letizia Mazzini, Andrea Calvo, Cristina Moglia, Adriano Chio
Summary: This study investigated the impact of immune responses on the clinical phenotype of ALS patients. Results revealed that immune responses were associated with disease progression, survival, and pulmonary function. Understanding the significance of immune dysregulation in ALS and further research may contribute to clinical practice and treatments.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Hematology
F. Mulder, E. Horvath-Puho, N. van Es, H. W. M. van Laarhoven, L. Pedersen, F. Moik, C. Ay, H. R. Buller, H. T. Sorensen
Summary: Over the past decade, the incidence of venous thromboembolism (VTE) in cancer patients may have changed due to novel cancer therapies, improved survival, and high-resolution imaging. The risk of VTE in cancer patients is steadily increasing and is ninefold higher than in the general population.
Article
Oncology
Jianhui Qiu, Desheng Cai, Zixin Wang, Jingcheng Zhou, Yanqing Gong, Lin Cai, Kan Gong
Summary: The study found that GP 5 + 4 was associated with higher risks of all-cause mortality and cancer-specific mortality compared to GP 4 + 5 among patients with GS 9 prostate cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Lisa A. Cannon-Albright, Norman L. Foster, Karen Schliep, James M. Farnham, Craig C. Teerlink, Heydon Kaddas, Joann Tschanz, Chris Corcoran, John S. K. Kauwe
Article
Oncology
N. Lynn Henry, Lisa A. Cannon-Albright
Article
Oncology
Frederick S. Albright, Wendy Kohlmann, Leigh Neumayer, Saundra S. Buys, Cindy B. Matsen, Kimberly A. Kaphingst, Lisa A. Cannon-Albright
CANCER CAUSES & CONTROL
(2019)
Article
Oncology
Karen Curtin, Lisa A. Cannon-Albright, James VanDerslice, Zhe Yu, Kimberly A. Herget, Ramya Thota, Deborah W. Neklason
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2019)
Article
Oncology
Diana Abbott, Schuyler O'Brien, James M. Farnham, Erin L. Young, Jeffrey Yap, Kevin Jones, Stephen L. Lessnick, R. Lor Randall, Joshua D. Schiffman, Lisa A. Cannon-Albright
Article
Genetics & Heredity
Heather M. Ochs-Balcom, Priyanka Kanth, James M. Farnham, Samir Abdelrahman, Lisa A. Cannon-Albright
GENETIC EPIDEMIOLOGY
(2020)
Article
Oncology
Lisa A. Cannon-Albright, James M. Farnham, Jeffrey Stevens, Craig C. Teerlink, Cheryl A. Palmer, Kerry Rowe, Melissa H. Cessna, Deborah T. Blumenthal
Summary: Inherited contribution to primary brain cancer has been identified through linkage analysis of high-risk brain cancer pedigrees. Potential predisposition genes and candidate regions have been identified through genome-wide linkage analysis of these families.
Article
Oncology
Lisa Anne Cannon-Albright, Craig Carl Teerlink, Jeff Stevens, Franklin W. Huang, Csilla Sipeky, Johanna Schleutker, Rolando Hernandez, Julio Facelli, Neeraj Agarwal, Donald L. Trump
Summary: This study utilized a predisposition candidate gene identification strategy to identify 152 bladder cancer predisposition candidate variants in affected bladder cancer relative pairs from high-risk pedigrees, with one variant in ERF significantly associated with bladder cancer risk in an independent population, suggesting it may be a predisposition gene for bladder and prostate cancer.
Article
Oncology
Heather M. Ochs-Balcom, Priyanka Kanth, Lisa A. Cannon-Albright
Summary: Research has shown that first- and second-degree relatives of early-onset CRC cases have elevated risks of developing early-onset CRC, with respective RRs of 6.0 and 3.1. Family history contributes to non-syndromic early-onset CRC, and the affected location may not necessarily be similar to that of the relatives.
CANCER EPIDEMIOLOGY
(2021)
Article
Oncology
Craig C. Teerlink, Jeff Stevens, Rolando Hernandez, Julio C. Facelli, Lisa A. Cannon-Albright
Summary: A rare intronic variant of the CELF4 gene was significantly associated with colorectal cancer (CRC) risk and shown to segregate within a high-risk pedigree. This provides further support for the role of this variant in CRC risk.
CANCER EPIDEMIOLOGY
(2021)
Article
Psychiatry
Lisa A. Cannon-Albright, Jennifer Romesser, Craig C. Teerlink, Alun Thomas, Lawrence J. Meyer
Summary: This study linked genealogy with patient data to analyze familial clustering of Post Traumatic Stress Disorder (PTSD) in the United States. The results suggest an inherited contribution to PTSD predisposition and provide valuable resources for identifying predisposition genes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Oncology
Lisa A. Cannon-Albright, Craig C. Teerlink, Jeff Stevens, Julio C. Facelli, Shamus R. Carr, Kristina Allen-Brady, Sonam Puri, Joan E. Bailey-Wilson, Anthony M. Musolf, Wallace Akerley
Summary: A unique approach with rare resources was used to identify candidate variants predisposing to familial nonsquamous nonsmall-cell lung cancers (NSNSCLC). Variants were tested for association with lung cancer risk in UK Biobank. This unique study identified multiple candidate predisposition variants for NSNSCLC, including a rare variant in FGF5 that was significantly associated with lung cancer risk and that segregated with lung cancer in the two pedigrees in which it was observed.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Lisa A. Cannon-Albright, Jeff Stevens, Julio C. Facelli, Craig C. Teerlink, Kristina Allen-Brady, Neeraj Agarwal
Summary: This study identified a rare variant in the LRBA gene that is significantly associated with prostate cancer risk. The variant was shared among 51 affected cousin pairs who died from the disease. Further analysis showed the variant to be present in multiple pedigrees. These findings provide candidate genes and mutation sites for further research on the genetic risk of prostate cancer.
Article
Environmental Sciences
David Valentine, Craig C. Teerlink, James M. Farnham, Kerry Rowe, Heydon Kaddas, JoAnn Tschanz, John S. K. Kauwe, Lisa A. Cannon-Albright
Summary: Analysis of individuals at high risk for Alzheimer's disease (AD) found lower incidence of diabetes, hypertension, and heart disease, but higher incidence of various cancers. This suggests a possible link between AD risk and other diseases that warrants further investigation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Lisa A. Cannon-Albright, Craig C. Teerlink, Jeffrey Stevens, Angela K. Snow, Bryony A. Thompson, Russell Bell, Kim N. Nguyen, Nykole R. Sargent, Wendy K. Kohlmann, Deborah W. Neklason, Sean Tavtigian
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
