Article
Agriculture, Multidisciplinary
Lina Zhang, Jinyue Zhang, Binsong Han, Chen Chen, Jun Liu, Zhaona Sun, Min Liu, Peng Zhou
Summary: This study investigated changes in the protein profile of colostrum between mothers with gestational diabetes mellitus (GDM) and healthy mothers, identifying significant differences in proteins related to carbohydrate and lipid metabolism pathways as well as immunity. Additionally, glycated peptides were upregulated while glycosylated peptides were downregulated in colostrum with GDM, providing insights for infant formula adjustment for infants from mothers with GDM.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
M. Tortades, E. Garcia-Fruitos, A. Aris, M. Terre
Summary: Colostrum, the first milk, is crucial for neonatal survival due to its high nutrient concentrations and bioactive substances. This study aimed to measure the concentrations of IGF-I, IgG, and LTF in colostrum and transition milk and assess their potential use in veterinary and nutraceutical applications. The results showed a decrease in the concentrations of these bioactive molecules from the first milking to the tenth, with greater concentrations observed in multiparous cows. Transition milk exhibited a 46% decrease in the analyzed bioactive molecules. Further research is needed to apply this knowledge in neonate farm management or pharmaceutical supplements.
Article
Biochemistry & Molecular Biology
Leticia Damas Leao Dalcin, Danny Laura Gomes Fagundes-Triches, Adriele Ataides de Queiroz, Andre Henrique Furtado Torres, Danielle Cristina Honorio Franca, Tatiane Araujo Soares, Luana Cristina da Silva Ramos, Carla Roberta Silva Souza Antonio, Mahmi Fujimori, Eduardo Luzia Franca, Adenilda Cristina Honorio-Franca
Summary: This study aimed to determine the functional activity of macrophages present in the breast milk and colostrum of diabetic mothers with obesity and the effects of resistin on these cells. The data suggest that hyperglycemia associated with low-grade inflammation caused by obesity affects the percentage of cells expressing CD14(+)CD95(+), death by apoptosis, and microbicidal indices; meanwhile, resistin restored the microbicidal activity of colostrum cells.
Article
Agriculture, Multidisciplinary
Jonatan Jafet Uuh-Narvaez, Elizabeth Negrete-Leon, Juan Jose Acevedo-Fernandez, Maira Rubi Segura-Campos
Summary: This study provides evidence on the potential health benefits of Mayan plant foods in lowering blood sugar levels, suggesting that these foods could contribute to the development of therapeutic diet strategies for diabetes prevention and treatment.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Medicine, Research & Experimental
Kai-Chia Yeh, Teng-Kuang Yeh, Chung-Yu Huang, Chih-Bo Hu, Min-Hsien Wang, Yu-Wen Huang, Ling-Hui Chou, Hsuan-Hui Ho, Jen-Shin Song, Tsu Hsu, Weir-Torn Jiaang, Yu-Sheng Chao, Chiung-Tong Chen
Summary: DBPR108 is a novel DPP-4-selective inhibitor that has demonstrated potent in vivo pharmacological effects and good safety profiles in animals. By inhibiting DPP-4 activity, it increases active GLP-1 and insulin levels while improving glucose tolerability in animals.
Article
Plant Sciences
K. Mohamed Shafi, Radha Sivarajan Sajeevan, Sania Kouser, Chethala N. Vishnuprasad, Ramanathan Sowdhamini
Summary: This study investigates the antidiabetic potential of Moringa concanensis Nimmo (MC) and Moringa oleifera Lam. (MO) by using transcriptome profiling, metabolite analysis, and in vitro assay studies. The findings suggest that compounds in leaf tissue, such as quercetin, benzylamine, and chlorogenic acid, could play a significant role in the antidiabetic activity. MC shows a slightly higher effect in expression, abundance, and inhibitory activity compared to MO.
Article
Food Science & Technology
Shilpa Vij, Reenu Kashyap, Kapil Singh Narayan
Summary: In this study, bioactive peptides with immunomodulatory and antimicrobial activity were successfully isolated and identified from fermented buffalo colostrum whey. The peptide fraction of <10 kDa exhibited remarkable immunomodulatory activity, while the permeate fraction of <10 kDa showed higher antimicrobial activity against E. coli pathogens.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Engineering, Chemical
S. G. Borad, A. K. Singh, G. S. Meena, S. Arora, P. N. Raju, L. Sabikhi
Summary: A study was conducted to develop spray dried immunoglobulin-rich colostrum powder with optimized conditions, retaining 88.5% of total Igs and achieving excellent insolubility index in the powder. The rheological analysis of protein-rich preparations proved useful in optimizing the spray drying conditions without compromising protein bioactivity and reconstitution properties.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Food Science & Technology
Fernanda S. Fajardo-Espinoza, Cynthia Ordaz-Pichardo, Uma Sankar, Andres Romero-Rojas, Mario A. Moreno-Eutimio, Humberto Hernandez-Sanchez
Summary: This study demonstrates the cytotoxic and immunostimulatory potential of colostrum whey protein hydrolysates, which can reduce the viability of breast cancer cells and increase the proliferation of blood cells. The hydrolysates also show significantly higher cytotoxicity towards prostate cancer cells compared to colostrum whey protein.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biophysics
Roja Hadianamrei, Mhd Anas Tomeh, Stephen Brown, Jiqian Wang, Xiubo Zhao
Summary: This study focused on the development and characterization of short cationic amphiphilic beta-sheet forming anticancer peptides. The peptides exhibited selective anticancer activity influenced by their surface activity and secondary structure in hydrophobic surfaces, leading to disruption of mitochondrial membranes and apoptosis. Insights gained from the study can be used to design new ACPs with improved anticancer activity and lower toxicity against normal cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Research & Experimental
Zhang Shiming, Kit-Kay Mak, Madhu Katyayani Balijepalli, Srikumar Chakravarthi, Mallikarjuna Rao Pichika
Summary: The herbal medicine from Swietenia macrophylla seeds has been shown to help control blood sugar levels, with the bioactive compound Swietenine being responsible for reducing blood glucose levels. Studies have found a significant synergistic effect with Metformin when Swietenine is used in combination, improving dysregulated serum parameters in Streptozotocin-induced diabetic rats.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Valentina Serra, Marta Castrica, Stella Agradi, Giulio Curone, Daniele Vigo, Alessia Di Giancamillo, Silvia Clotilde Modina, Federica Riva, Claudia Maria Balzaretti, Roberta De Bellis, Gabriele Brecchia, Grazia Pastorelli
Summary: This study aimed to investigate the effects of dietary supplementation of two concentrations (2.5% and 5%) of bovine colostrum (BC) on the antioxidant status in various tissues of rabbits. The results showed no significant differences in the plasma concentration of antioxidant enzymes or in the gene expression of these enzymes in the liver and muscle samples of rabbits. Further studies are needed to fully understand the potential value of BC in rabbit meat.
Article
Food Science & Technology
Carlotta Bollati, Ivan Cruz-Chamorro, Gilda Aiello, Jianqiang Li, Martina Bartolomei, Guillermo Santos-Sanchez, Giulia Ranaldi, Simonetta Ferruzza, Yula Sambuy, Anna Arnoldi, Carmen Lammi
Summary: This study identified and evaluated antioxidant peptides from hempseed peptic hydrolysate. Two of the peptides showed the ability to reduce oxidative stress and inflammation in cells.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Oriol Barcenas, Carlos Pintado-Grima, Katarzyna Sidorczuk, Felix Teufel, Henrik Nielsen, Salvador Ventura, Michal Burdukiewicz
Summary: This minireview provides a systematic and accessible analysis of the complex ecosystem of peptide activity prediction, showcasing the variability and popularity of existing models. The reproducibility of bioinformatics tools and their development trends are also evaluated.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Oriol Barcenas, Carlos Pintado-Grima, Katarzyna Sidorczuk, Felix Teufel, Henrik Nielsen, Salvador Ventura, Michal Burdukiewicz
Summary: This article reviews the complex ecosystem of peptide activity prediction, showcasing the variability and popularity of existing peptide assessment models. It also evaluates the reproducibility of such bioinformatics tools and describes the trends observed in their development.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
