Article
Psychology, Biological
Jie Chen, Mengqi Zhao, Lina Huang, Yuansheng Liu, Xueying Li, Xize Jia, Qingguo Ding, Chunjie Wang, Pei Liang
Summary: By collecting resting-state functional magnetic resonance imaging (rs-fMRI) data from 22 participants, we found that sweet, sour, and tasteless gustatory stimulation had different effects on the functional activity in brain regions, including somatosensory areas, reward processing areas, and high-order cognitive functioning areas. These findings contribute to a further understanding of the neural network and mechanisms after taste exposure.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei-Yu Yeh, Henry S. Chen, Ping Hou, Vinodh A. Kumar, Jason M. Johnson, Kyle R. Noll, Sujit S. Prabhu, Sherise D. Ferguson, Donald F. Schomer, Hsu-Hsia Peng, Ho-Ling Liu
Summary: This study investigated the utilization of resting-state blood oxygenation level-dependent signal for cerebrovascular reactivity mapping in patients with gliomas. The optimal frequency ranges for rs-CVR were determined to be 0.04-0.08 Hz and 0.02-0.04 Hz, showing higher correlations with breath-hold MRI results compared to resting-state fluctuation amplitude method.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Shengwen Deng, Crystal G. Franklin, Michael O'Boyle, Wei Zhang, Betty L. Heyl, Paul A. Jerabek, Hanzhang Lu, Peter T. Fox
Summary: The study aims to quantify spatial correspondences between voxel-based physiological (VBP) variables derived from blood oxygen level dependent (BOLD) fMRI and PET measurements of cerebral metabolic rate and hemodynamics. The results show significant correspondences between ALFF and blood volume (BV), between fALFF and metabolic rate of glucose (MRGlu), oxygen consumption (MRO2), blood flow (BF) and BV, as well as between ReHo and MRGlu, MRO2, BF, and BV. However, the strength of the PET-BOLD correspondences varies by brain region.
Article
Neurosciences
Seyedmohammad Shams, Prokopis Prokopiou, Azin Esmaelbeigi, Georgios D. Mitsis, J. Jean Chen
Summary: Conventionally, cerebrovascular reactivity (CVR) is estimated as the amplitude of the hemodynamic response to vascular stimuli, most commonly carbon dioxide (CO2). While the CVR amplitude has established clinical utility, the temporal characteristics of CVR (dCVR) have been increasingly explored and may yield even more pathology-sensitive parameters. This work compares several model-based deconvolution approaches for estimating the CO2 response function and proposes a novel simulation framework to aid the comparison. The findings suggest that model-based methods can accurately estimate dCVR even amidst high noise and provide a quantitative basis for methodological choices.
Article
Neurosciences
Rachael C. Stickland, Kristina M. Zvolanek, Stefano Moia, Apoorva Ayyagari, Cesar Caballero-Gaudes, Molly G. Bright
Summary: The study evaluated a modification to a resting-state fMRI protocol by adding a breathing task to enhance the characterization of cerebrovascular function, demonstrating the importance of CVR response amplitude and lag in understanding cerebral vascular pathologies and reducing noise confounds. The inclusion of a simple breathing task not only increased the number of brain voxels showing a significant relationship between CO 2 and BOLD-fMRI signals, but also improved confidence in voxel-wise CVR and hemodynamic lag estimates, with implications for research and clinical applications.
Article
Neurosciences
Yawen Liu, Haijun Niu, Tingting Zhang, Linkun Cai, Dong Liu, Erwei Zhao, Liang Zhu, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study aimed to explore the association between cardiovascular and spontaneous brain activities during dobutamine infusion in healthy young adults. The results showed that blood pressure and heart rate significantly increased after dobutamine infusion, and there was a decrease in brain functional activity in certain regions. These findings suggest that brain-heart interactions exist in healthy young adults under acute cardiovascular alterations.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Kaihua Jiang, Yang Yi, Li Ding, Hongxin Li, Lin Li, Aibin Zheng
Summary: This study investigated cognitive functional differences between children with primary nocturnal enuresis (PNE) of different genders through brain imaging and behavioral experiments. The results showed that PNE boys performed better than PNE girls in both brain activities and behavioral performance. This research contributes to understanding the impact of PNE on cognitive functions in children.
Article
Neurosciences
Jingxuan Gong, Rachael C. Stickland, Molly G. Bright
Summary: This study found that the timing of arterial blood flow is more reliably characterized when a larger systemic vascular response is evoked by a breathing challenge compared to when only spontaneous fluctuations in vascular physiology are present. However, it is not clear whether the hemodynamic delays in these two conditions are physiologically interchangeable, and how methodological signal-to-noise factors may limit their agreement.
Article
Endocrinology & Metabolism
Norman Scheel, Takashi Tarumi, Tsubasa Tomoto, C. Munro Cullum, Rong Zhang, David C. Zhu
Summary: The study suggests that local brain blood fluctuations due to vascular hemodynamics or neuronal activity may affect the homeostasis of Aβ in individuals at high risk of AD.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Muwei Li, Yurui Gao, Adam W. Anderson, Zhaohua Ding, John C. Gore
Summary: Recent studies have shown that the mathematical model used for analyzing fMRI data in gray matter is not suitable for detecting BOLD signals in white matter. Our findings reveal the non-stationary nature of BOLD signals in white matter, with distinct spectral patterns that can be categorized into five recurring modes.
Article
Neurosciences
Jianfeng Zhang, Dong-Qiang Liu, Shufang Qian, Xiujuan Qu, Peiwen Zhang, Nai Ding, Yu-Feng Zang
Summary: This study investigates the neural correlates of fMRI-ALFF by comparing the amplitude differences between eyes-closed and eyes-open states in fMRI and MEG. The results show that MEG-ALFF increases at parietal sensors, overlapping with the EC-EO differences observed in fMRI. These findings suggest that the amplitude in MEG reflects distinct physiological information and that fMRI-ALFF may be related to the ALFF in neural activity.
Article
Physics, Multidisciplinary
Maria Guidi, Giovanni Giulietti, Emma Biondetti, Richard Wise, Federico Giove
Summary: Neurovascular alterations play a key role in many brain diseases and can be effectively observed and measured using MRI techniques. The current MRI sequences provide reliable markers for vascular dysfunction, but further research is needed to observe vascular changes at a finer scale.
FRONTIERS IN PHYSICS
(2023)
Article
Neurosciences
Lucas E. Sainburg, Aubrey A. Little, Graham W. Johnson, Andrew P. Janson, Kaela K. Levine, Hernan F. J. Gonzalez, Baxter P. Rogers, Catie Chang, Dario J. Englot, Victoria L. Morgan
Summary: This study investigates the fMRI signal alterations in patients with mesial temporal lobe epilepsy (mTLE) and provides insights into the relationship between these alterations and the severity of the disease. It also reveals the potential spread of epileptic fMRI activity across networks and the distinct properties of fMRI activity in the default mode network of mTLE patients.
Article
Clinical Neurology
Hussam Metwali, Tamer Ibrahim, Mathijs Raemaekers
Summary: Resting-state networks (RSNs) under anesthesia can be used for intraoperative brain mapping and remapping during tumor resection, but there is a significant decrease in network connectivity with the continuation of anesthesia.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Atsushi Fujimoto, Catherine Elorette, J. Megan Fredericks, Satoka H. Fujimoto, Lazar Fleysher, Peter H. Rudebeck, Brian E. Russ
Summary: This study used noninvasive neuroimaging techniques to assess the impact of a drug on brain functional connectivity. The results showed that an appropriate dose of the drug did not alter brain connectivity, while an excess dose of the drug increased functional connectivity in the frontal regions and may cause deficits related to attention or motivation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Computer Science, Interdisciplinary Applications
Mathew Birdsall Abrams, Jan G. Bjaalie, Samir Das, Gary F. Egan, Satrajit S. Ghosh, Wojtek J. Goscinski, Jeffrey S. Grethe, Jeanette Hellgren Kotaleski, Eric Tatt Wei Ho, David N. Kennedy, Linda J. Lanyon, Trygve B. Leergaard, Helen S. Mayberg, Luciano Milanesi, Roman Moucek, J. B. Poline, Prasun K. Roy, Stephen C. Strother, Tong Boon Tang, Paul Tiesinga, Thomas Wachtler, Daniel K. Wojcik, Maryann E. Martone
Summary: There is a great need for coordination around standards and best practices in neuroscience to address challenges in data science. Developing community standards and gaining their adoption is difficult, as the current landscape is characterized by a lack of robust, validated standards and a plethora of underdeveloped and underutilized standards and best practices. An independent organization, the International Neuroinformatics Coordinating Facility (INCF), is dedicated to promoting data sharing in neuroscience and has implemented procedures for evaluating and endorsing community standards and best practices.
Correction
Computer Science, Interdisciplinary Applications
Mathew Birdsall Abrams, Jan G. Bjaalie, Samir Das, Gary F. Egan, Satrajit S. Ghosh, Wojtek J. Goscinski, Jeffrey S. Grethe, Jeanette Hellgren Kotaleski, Eric Tatt Wei Ho, David N. Kennedy, Linda J. Lanyon, Trygve B. Leergaard, Helen S. Mayberg, Luciano Milanesi, Roman Moucek, J. B. Poline, Prasun K. Roy, Stephen C. Strother, Tong Boon Tang, Paul Tiesinga, Thomas Wachtler, Daniel K. Wojcik, Maryann E. Martone
Review
Psychiatry
Pedro L. Ballester, Maria T. Romano, Taiane de Azevedo Cardoso, Stefanie Hassel, Stephen C. Strother, Sidney H. Kennedy, Benicio N. Frey
Summary: The study conducted a systematic review and meta-analysis to evaluate accelerated brain aging in individuals with mood or psychotic disorders. The results showed that individuals with these disorders may undergo a process of accelerated brain aging, with older individuals showing a more pronounced brain age gap, indicating a possible cumulative biological effect of illness burden.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Neurosciences
Sondos Ayyash, Andrew D. Davis, Gesine L. Alders, Glenda MacQueen, Stephen C. Strother, Stefanie Hassel, Mojdeh Zamyadi, Stephen R. Arnott, Jacqueline K. Harris, Raymond W. Lam, Roumen Milev, Daniel J. Mueller, Sidney H. Kennedy, Susan Rotzinger, Benicio N. Frey, Luciano Minuzzi, Geoffrey B. Hall
Summary: There is a growing interest in exploring the data fusion analysis of functional and structural imaging sources. A novel processing pipeline, FATCAT-awFC, was developed to identify connectivity changes in MDD patients compared to healthy individuals, revealing significant differences in specific brain networks. By combining structural and functional data, this method enhances our understanding of the intricate relationship between structural and functional connectivity in depression.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Aras Kayvanrad, Stephen R. Arnott, Nathan Churchill, Stefanie Hassel, Aditi Chemparathy, Fan Dong, Mojdeh Zamyadi, Tom Gee, Robert Bartha, Sandra E. Black, Jane M. Lawrence-Dewar, Christopher J. M. Scott, Sean Symons, Andrew D. Davis, Geoffrey B. Hall, Jacqueline Harris, Nancy J. Lobaugh, Glenda MacQueen, Cindy Woo, Stephen Strother
Summary: Quality assurance (QA) is crucial in longitudinal and/or multi-site studies to monitor scanner performance over time and location, detecting and controlling for intrinsic differences and changes in scanner performance. Using phantom scans and QA parameters, variations in image resolution measured by the FWHM were identified as a primary source of variance over time for many sites, as well as between sites and between manufacturers. An unexpected range of instabilities affecting individual slices in a number of scanners were also found, with a preprocessing approach to reduce variance and alleviate anomalies identified.
Article
Clinical Neurology
F. Elizabeth Godkin, Erin Turner, Youness Demnati, Adam Vert, Angela Roberts, Richard H. Swartz, Paula M. McLaughlin, Kyle S. Weber, Vanessa Thai, Kit B. Beyer, Benjamin Cornish, Agessandro Abrahao, Sandra E. Black, Mario Masellis, Lorne Zinman, Derek Beaton, Malcolm A. Binns, Vivian Chau, Donna Kwan, Andrew Lim, Douglas P. Munoz, Stephen C. Strother, Kelly M. Sunderland, Brian Tan, William E. McIlroy, Karen Van Ooteghem
Summary: The study found that continuous multi-sensor remote health monitoring is feasible in individuals with cerebrovascular disease or neurodegenerative disease, with high adherence to device wearing, mainly during daytime, and positive feedback from both participants and study partners.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Xiaole Z. Zhong, J. Jean Chen
Summary: This study investigates the age and sex effects on the frequency content of the rs-fMRI signal using the Leipzig mind-brain-body data set. The findings demonstrate that the rs-fMRI fluctuation frequency is higher in older adults, and men have higher rs-fMRI frequency than women. The effects of age and sex on fMRI frequency vary with frequency band examined.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Simon Dobri, J. Jean Chen, Bernhard Ross
Summary: This study investigated the impact of aging on brain function and GABA levels. The results showed a decline in GABA levels during aging, but the ratio of GABA+ to creatine and N-acetyl aspartate also decreased. Young and older adults showed hemispheric asymmetry in GABA+ measures. By considering multiple GABA+ measures and different reference signals, the evidence for an aging-related decline in auditory cortex GABA levels was strengthened.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Hiba T. Taha, Jordan A. Chad, J. Jean Chen
Summary: This study utilizes diffusion kurtosis imaging to investigate diffusion patterns in the aging brain, revealing lower kurtosis and higher diffusivity in older adults, with kurtosis being more sensitive to age.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Ali M. Golestani, J. Jean Chen
Summary: Effective separation of signal from noise is a challenge in improving the sensitivity and specificity of resting-state fMRI measurements. Independent component analysis (ICA) is a useful approach for addressing this challenge. Our study found that spatial ICA (sICA) can identify more noise-related signal components, while temporal ICA (tICA) performs better in dealing with physiological effects.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychiatry
Farhana Islam, Victoria S. Marshe, Leen Magarbeh, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar Parikh, Franca Placenza, Stephen C. Strother, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Rudolf Uher, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Daniel J. Mueller
Summary: Cytochrome P450 drug-metabolizing enzymes, specifically CYP2C19 and CYP2D6 gene variants, have an impact on antidepressant outcomes. Poor metabolizers of CYP2C19 and CYP2D6 show less symptom improvement during treatment with escitalopram alone and are more likely to experience central nervous system side effects when taking escitalopram alone or in combination with aripiprazole.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Seyedmohammad Shams, Prokopis Prokopiou, Azin Esmaelbeigi, Georgios D. Mitsis, J. Jean Chen
Summary: Conventionally, cerebrovascular reactivity (CVR) is estimated as the amplitude of the hemodynamic response to vascular stimuli, most commonly carbon dioxide (CO2). While the CVR amplitude has established clinical utility, the temporal characteristics of CVR (dCVR) have been increasingly explored and may yield even more pathology-sensitive parameters. This work compares several model-based deconvolution approaches for estimating the CO2 response function and proposes a novel simulation framework to aid the comparison. The findings suggest that model-based methods can accurately estimate dCVR even amidst high noise and provide a quantitative basis for methodological choices.
Article
Endocrinology & Metabolism
Arjun Patel, Jordan A. A. Chad, J. Jean Chen
Summary: This study explores the relationship between obesity and brain health, specifically focusing on the differences between males and females. The findings suggest that there are sex differences in the association between adiposity and intelligence as well as white matter microstructure. This highlights the importance of considering sex-driven differences when studying the impact of obesity on brain degeneration.
Article
Neuroimaging
Pedro L. Ballester, Jee Su Suh, Nikita Nogovitsyn, Stefanie Hassel, Stephen C. Strother, Stephen R. Arnott, Luciano Minuzzi, Roberto B. Sassi, Raymond W. Lam, Roumen Milev, Daniel J. Muller, Valerie H. Taylor, Sidney H. Kennedy, Benicio N. Frey
Summary: The study found an elevated brain age gap in older individuals with major depressive disorder (MDD). Additionally, body mass index (BMI) was significantly associated with brain age gap in the MDD group. However, the brain age gap was not significantly associated with treatment response.
NEUROIMAGE-CLINICAL
(2021)
Meeting Abstract
Clinical Neurology
G. Coughlan, P. McLaughlin, K. Sunderland, M. Borrie, C. Fischer, A. Frank, M. Freedman, S. Kumar, S. Pasternak, B. Pollock, T. Rajji, D. Seitz, D. Tang-Wai, C. Tartaglia, J. Dewar, D. Kwan, B. Tan, D. Grimes, M. Jog, T. Lang, C. Marras, T. Steeves, D. Bulman, A. Dilliott, M. Ghani, R. Hegele, J. Robinson, E. Rogaeva, S. Farhan, R. Bartha, N. Nanayakkara, J. Ramirez, C. Scott, S. Symons, C. Berezuk, M. Holmes, S. Adamo, M. Ozzoude, A. Theyers, S. Arnott, D. Beaton, W. Lou, S. Sujanthan, B. Levine, J. Orange, A. Peltsch, A. Roberts, A. Troyer, M. Binns, S. Black, S. Strother, M. Moscovitch, C. Grady, M. Masellis
MOVEMENT DISORDERS
(2021)