Article
Biochemistry & Molecular Biology
Hager Tarek H. Ismail, Manar AbdelMageed, Gudrun Lindmark, Marie-Louise Hammarstrom, Sten Hammarstrom, Basel Sitohy
Summary: This study investigated the prognostic value of GPR55 in colon cancer. Combining GPR55 with CEA, CXCL16, or CXCL17 improved the discrimination between high and low expression groups. The GPR55/CEA ratio showed the best result, with a significant increase in mean survival time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Isabella Gigante, Valeria Tutino, Francesco Russo, Valentina De Nunzio, Sergio Coletta, Raffaele Armentano, Alberto Crovace, Maria Gabriella Caruso, Antonella Orlando, Maria Notarnicola
Summary: The study found that a high-fat diet can improve gastrointestinal symptoms and functions in an animal model of IBS by restoring intestinal tissue damage, upregulating CB1 and CB2 receptors, and affecting glucose metabolism and intestinal membrane permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Thangesweran Ayakannu, Anthony H. Taylor, Justin C. Konje
Summary: The expression of GPR55 was found to be significantly higher in patients with endometrial cancer compared to control tissues. GPR55 levels were correlated with its transcript levels and inversely correlated with CB2 receptor protein expression, suggesting a potential role for GPR55 as a biomarker and therapeutic target in endometrial cancer.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ayat Zagzoog, Ashley Cabecinha, Hanan Abramovici, Robert B. Laprairie
Summary: Cannabis sativa contains numerous cannabinoids and terpene compounds, and their pharmacological effects, interactions, and impact on physiological outcomes need further investigation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agricultural Engineering
Avia Saloner, Nirit Bernstein
Summary: Nitrogen supply affects cannabinoid and terpenoid metabolism, with the optimal N level for both yield quantity and relatively high secondary metabolites content being 160 mg L-1. High N supply has adverse effects on the production of secondary compounds in cannabis, while promoting plant growth and biomass production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Organic
Ryosuke Tanaya, Takeshi Kodama, Yuan-E Lee, Yoko Yasuno, Tetsuro Shinada, Hironobu Takahashi, Takuya Ito, Hiroyuki Morita, Suresh Awale, Futoshi Taura
Summary: This study explores the synthesis of various CBGA analogues, including a liverwort-derived bibenzyl acid precursor, using CsPT4. The synthesized natural and new-to-nature cannabinoids exhibit potent cytotoxicity in human pancreatic cancer cells. CsPT4 has the potential to expand the diversity of cannabinoid biosynthesis with novel and improved biological activities.
Review
Medicine, General & Internal
Patrycja Szalwinska, Jakub Wlodarczyk, Antonino Spinelli, Jakub Fichna, Marcin Wlodarczyk
Summary: Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) have overlapping symptoms and relationships, with still unclear pathogenesis. Similar symptoms of IBS have been observed in some patients during remission of IBD, raising questions about the connection between these two conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Plant Sciences
Henry Lowe, Blair Steele, Joseph Bryant, Ngeh Toyang, Wilfred Ngwa
Summary: This article discusses the potential medicinal value of non-cannabinoid compounds in the cannabis plant, such as flavonoids and terpenes, and highlights one promising non-cannabinoid molecule, Caflanone, for clinical trials. The article suggests that many phytochemicals in cannabis have wide therapeutic potential.
Review
Neurosciences
Shana M. Augustin, David M. Lovinger
Summary: The legalization of cannabis and the decrease in risks have led to increased usage for medicinal and recreational purposes. However, the long-term use of cannabis can lead to drug tolerance and the development of Cannabis Use Disorder (CUD). Despite the widespread use of cannabis and cannabinoids, little is known about the neurobiological mechanisms associated with CUD and drug use, emphasizing the need for further research.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Agricultural Engineering
Nadav Danziger, Nirit Bernstein
Summary: Plant architecture modulation can increase standardization of the cannabinoid profile in cannabis by increasing concentrations at the lower parts of the plant. Genotype and architectural modulation have specific effects on cannabinoid standardization.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Multidisciplinary Sciences
Justin E. LaVigne, Ryan Hecksel, Attila Keresztes, John M. Streicher
Summary: Limited evidence suggests that terpenes found in Cannabis sativa may have cannabimimetic activity and can enhance cannabinoid activity. These multifunctional cannabimimetic ligands provide support for the entourage effect hypothesis, potentially enhancing the therapeutic properties of cannabinoids.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Ae Lim Kim, Young Jae Yun, Hyong Woo Choi, Chang-Hee Hong, Hyun Joo Shim, Jeong Hwan Lee, Young-Cheon Kim
Summary: In this study, the levels of various cannabinoids in different Cannabis cultivars were detected using different analytical methods, and a correlation between cannabinoid accumulation and gene expression levels was observed.
Review
Plant Sciences
Ziyan Xie, Yaolei Mi, Lingzhe Kong, Maolun Gao, Shanshan Chen, Weiqiang Chen, Xiangxiao Meng, Wei Sun, Shilin Chen, Zhichao Xu
Summary: Cannabis is a versatile crop used for fiber extraction, traditional Chinese medicine, and recreational drugs. Despite global prohibition, its medicinal value, particularly cannabidiol, is being recognized. Understanding the biosynthesis mechanism is crucial for promoting the medicinal application of Cannabis resources.
HORTICULTURE RESEARCH
(2023)
Article
Plant Sciences
Jan Rozanc, Petra Kotnik, Marko Milojevic, Lidija Gradisnik, Masa Knez Hrncic, Zeljko Knez, Uros Maver
Summary: Different extraction methods of cannabis were tested for their effects on cannabinoid content, antioxidant properties, and bioactivity on colon cancer and healthy colon cells. The results showed that properly prepared cannabis extracts can reduce cancer cell viability while protecting healthy cells. However, the post-processing of extracts poses a limitation in predicting therapeutic response based on the original composition.
Article
Oncology
Lubomir Vecera, Petr Prasil, Josef Srovnal, Emil Berta, Monika Vidlarova, Tomas Gabrhelik, Pavla Kourilova, Martin Lovecek, Pavel Skalicky, Jozef Skarda, Zdenek Kala, Pavel Michalek, Marian Hajduch
Summary: Patients with pancreatic cancer who received morphine for postoperative analgesia had longer cancer-specific survival compared to those who received piritramide. Additionally, high expressions of cannabinoid receptor 2 (CB2) and opioid growth factor receptor (OGFR) genes were associated with improved overall survival, while high expression of delta opioid receptor gene shortened survival.
Article
Biochemistry & Molecular Biology
Laura Pajed, Carina Wagner, Ulrike Taschler, Renate Schreiber, Stephanie Kolleritsch, Nermeen Fawzy, Isabella Pototschnig, Gabriele Schoiswohl, Lisa-Maria Pusch, Beatrix I. Wieser, Paul Vesely, Gerald Hoefler, Thomas O. Eichmann, Robert Zimmermann, Achim Lass
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Gernot F. Grabner, Nermeen Fawzy, Renate Schreiber, Lisa M. Pusch, Dominik Bulfon, Harald Koefeler, Thomas O. Eichmann, Achim Lass, Martina Schweiger, Gunther Marsche, Gabriele Schoiswohl, Ulrike Taschler, Robert Zimmermann
JOURNAL OF LIPID RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Peter Hofer, Ulrike Taschler, Renate Schreiber, Petra Kotzbeck, Gabriele Schoiswohl
Article
Biochemistry & Molecular Biology
Carina Wagner, Victoria Hois, Laura Pajed, Lisa-Maria Pusch, Heimo Wolinski, Michael Trauner, Robert Zimmermann, Ulrike Taschler, Achim Lass
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Biochemistry & Molecular Biology
Shalinee Jha, Ulrike Taschler, Oliver Domenig, Marko Poglitsch, Benjamin Bourgeois, Marion Pollheimer, Lisa M. Pusch, Grazia Malovan, Sasa Frank, Tobias Madl, Karl Gruber, Robert Zimmermann, Peter Macheroux
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Cell Biology
Niokhor Dione, Sebastien Lacroix, Ulrike Taschler, Thomas Deschenes, Armita Abolghasemi, Nadine Leblanc, Vincenzo Di Marzo, Cristoforo Silvestri
Article
Biology
Laura Pajed, Ulrike Taschler, Anna Tilp, Peter Hofer, Petra Kotzbeck, Stephanie Kolleritsch, Franz P. W. Radner, Isabella Pototschnig, Carina Wagner, Margarita Schratter, Sandra Eder, Sabrina Huetter, Renate Schreiber, Guenter Haemmerle, Thomas O. Eichmann, Martina Schweiger, Gerald Hoefler, Erin E. Kershaw, Achim Lass, Gabriele Schoiswohl
Summary: The study examines the role of adipocyte hormone-sensitive lipase (HSL) in regulating whole body energy homeostasis, showing that adipocyte-specific HSL knockout (AHKO) mice fed a high-fat diet develop fatty liver but may reverse with age. The reversal is possibly linked to diminished lipolytic activity in adipose tissue and pronounced lipodystrophy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carina Wagner, Victoria Hois, Annalena Eggeling, Lisa-Maria Pusch, Laura Pajed, Patrick Starlinger, Thierry Claudel, Michael Trauner, Robert Zimmermann, Ulrike Taschler, Achim Lass
Summary: KIAA1363 has been identified as a novel retinyl ester hydrolase, mainly expressed in hepatic stellate cells and exhibiting high activity at neutral pH. It localizes to the endoplasmic reticulum and affects vitamin A metabolism in hepatic stellate cells by hydrolyzing retinyl esters.
JOURNAL OF LIPID RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Carina Wagner, Victoria Hois, Ulrike Taschler, Michael Schupp, Achim Lass
Summary: This review explores the structure, function, and physiological role of KIAA1363, and suggests that it may be involved in drug detoxification and hydrolysis of endogenous substrates.
Article
Biochemistry & Molecular Biology
Petra Kotzbeck, Ulrike Taschler, Christoph Haudum, Ines Foessl, Gabriele Schoiswohl, Beate Boulgaropoulos, Kaddour Bounab, Johanna Einsiedler, Laura Pajed, Anna Tilp, Anna Schwarz, Thomas O. Eichmann, Barbara Obermayer-Pietsch, Antonio Giordano, Saverio Cinti, Rudolf Zechner, Thomas R. Pieber
Summary: Loss of HSL contributes to ER stress and adipose tissue inflammation, with macrophage infiltration in visceral fat. PPAR7 activation can reverse inflammation but not ER stress and DAG accumulation.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Julia S. Steinhoff, Carina Wagner, Ulrike Taschler, Sascha Wulff, Marie F. Kiefer, Konstantin M. Petricek, Sylvia J. Wowro, Moritz Oster, Roberto E. Flores, Na Yang, Chen Li, Yueming Meng, Manuela Sommerfeld, Stefan Weger, Andrea Henze, Jens Raila, Achim Lass, Michael Schupp
Summary: Hepatocytes secrete RBP4 to mobilize vitamin A and regulate glucose and fat metabolism. Acute retinol mobilization decreases body fat content and enhances fat turnover. FGF21 plays a key role in retinol mobilization and is associated with retinoic acid regulation in the liver.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Endocrinology & Metabolism
Gabriel Chalhoub, Alina Jamnik, Laura Pajed, Stephanie Kolleritsch, Victoria Hois, Antonia Bagaric, Dominik Prem, Anna Tilp, Dagmar Kolb, Heimo Wolinski, Ulrike Taschler, Thomas Zuellig, Gerald N. Rechberger, Claudia Fuchs, Michael Trauner, Gabriele Schoiswohl, Guenter Haemmerle
Summary: The abnormal generation of lipid metabolites and signaling molecules, including DAG and lysoPC, play a critical role in the development and progression of NAFLD. Ces2a and CES2 are key players in lipid metabolism, regulating the hydrolysis of DAG and lysoPC.
MOLECULAR METABOLISM
(2023)
Article
Oncology
Melanie Kienzl, Carina Hasenoehrl, Kathrin Maitz, Arailym Sarsembayeva, Ulrike Taschler, Paulina Valadez-Cosmes, Oliver Kindler, Dusica Ristic, Sofia Raftopoulou, Ana Santiso, Thomas Baernthaler, Luka Brcic, Lisa Hahnefeld, Robert Gurke, Dominique Thomas, Gerd Geisslinger, Julia Kargl, Rudolf Schicho
Summary: The MGL expressed in the tumor microenvironment plays a crucial role in promoting tumor growth in NSCLC, as shown by experiments with MGL inhibitor and MGL knock-out mice. Inhibition of MGL results in decreased tumor burden, accompanied by increased numbers of CD8(+) T cells and eosinophils, indicating enhanced tumoricidal activity.
Article
Biochemistry & Molecular Biology
Gabriel Chalhoub, Stephanie Kolleritsch, Lisa K. Maresch, Ulrike Taschler, Laura Pajed, Anna Tilp, Helgit Eisner, Philipp Rosina, Benedikt Kien, Franz P. W. Radner, Rudolf Schicho, Monika Oberer, Gabriele Schoiswohl, Guenter Haemmerle
Summary: Research showed that CES2/Ces2 members are highly efficient DG and MG hydrolases, potentially playing an important role in liver and gut lipid signaling. In addition to TG hydrolysis, Ces2a, Ces2b, and Ces2e exhibited significant enzymatic activities towards DGs and MGs.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Lisa Katharina Maresch, Pia Benedikt, Ursula Feiler, Sandra Eder, Kathrin A. Zierler, Ulrike Taschler, Stephanie Kolleritsch, Thomas O. Eichmann, Gabriele Schoiswohl, Christina Leopold, Beatrix I. Wieser, Caroline Lackner, Thomas Ruelicke, Jan van Klinken, Dagmar Kratky, Tarek Moustafa, Gerald Hoefler, Guenter Haemmerle
HEPATOLOGY COMMUNICATIONS
(2019)