Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Rui Wang, Malina Kuerman, Qingyu Cui, Xiaoying Tian, Yu Zhou, Huaxi Yi, Pimin Gong, Kai Lin, Zhe Zhang, Tongjie Liu, Lanwei Zhang
Summary: This study investigates the potential mechanisms of different probiotic strains in preventing intestinal barrier damage. The results show that Bifidobacterium bifidum FL-228.1 exhibits the best prophylactic effects in protecting against intestinal barrier damage. Further research suggests that FL-228.1 achieves this by enhancing the production of Muc2 and Cldn-4, inhibiting NLRP3 activation, and activating PPAR gamma and TLR2.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Qiuyu Zhang, Lei Cheng, Junjuan Wang, Mengzhen Hao, Huilian Che
Summary: Antibiotic-induced dysbiosis of gut microbiota increases susceptibility and severity of food allergies, possibly due to increased intestinal permeability caused by decreased tight junction proteins and enhanced inflammatory response.
Review
Immunology
Yingman Liu, Wenxuan Huang, Jiaqi Wang, Jiaojiao Ma, Manman Zhang, Xiaoying Lu, Jie Liu, Yurong Kou
Summary: Periodontal disease, considered a common inflammatory disease, is believed to contribute to the development of gastrointestinal diseases and other systemic diseases by affecting the intestinal barrier through periodontal pathogens. This review summarizes studies on the effects of periodontal pathogens on the intestinal barrier, potentially shedding light on the link between periodontitis and gastrointestinal diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Xue Yang, Yanan Gao, Shengnan Huang, Chuanyou Su, Jiaqi Wang, Nan Zheng
Summary: Ochratoxin A (OTA) is a widespread environmental pollutant that poses a threat to humans and livestock and remains a global public health concern. OTA-induced damage to tight junction (TJ) proteins may be related to the activation of the WNT/Ca2+ signaling pathway, possibly regulated by key lncRNAs and miRNAs. Competing endogenous RNA (ceRNA) network analysis revealed that lncRNA Zeb1 regulates the release of Ca2+ by targeting miR-1258-x, which in turn reduces TJ protein expression and damages intestinal barrier function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Agriculture, Dairy & Animal Science
Reza Barekatain, Tristan Chalvon-Demersay, Clive McLaughlan, William Lambert
Summary: The study found that amino acids can improve feed efficiency and reduce intestinal inflammation in broilers, with potential effects on intestinal permeability. Amino acids have the potential to optimize intestinal barrier function, particularly under stress-related conditions, through different pathways.
Article
Agriculture, Multidisciplinary
Jiaojiao Zhang, Qinpei Li, Liying Wu, Shichen Xu, Rongrong Lu
Summary: The study demonstrates that four surface-layer proteins (Slps) from different Lactobacillus strains can prevent TNF-alpha-induced dysfunction of the intestinal barrier by blocking the nuclear factor-kappa B signaling pathway.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Veterinary Sciences
Ruibiao Wang, Yuheng Zhang, Jingbo Zhen, Jinpeng Zhang, Zixuan Pang, Xuewei Song, Lihao Lin, Feng Sun, Yixin Lu
Summary: This study explored the effect of exosomes derived from Trichinella spiralis infective larvae (TsExos) on the barrier function of porcine small intestinal epithelial cells (IPEC-J2). The results showed that TsExos ingestion decreased cell viability, increased FITC-dextran content, lactate dehydrogenase and reactive oxygen species levels. TsExos also induced apoptosis, nuclear pyknosis, and nuclear rupture. In addition, TsExos disrupted tight junctions and altered gene expression.
VETERINARY RESEARCH
(2022)
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, Research & Experimental
Haishan Wu, Rong Huang, Jinjin Fan, Ning Luo, Xiao Yang
Summary: Low potassium diet may increase intestinal permeability, leading to bacterial translocation, suspected to be due to impaired intestinal epithelial barrier and biological barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jingru Guo, Jing Xu, Leichong Chen, Zhuo Chen, Huijie Hu, Junshu Nie, Jianbin Yuan, Li Ma, Jingjing Lu, Hong Ji, Bin Xu
Summary: This study revealed that chronic cold exposure damages the ileal epithelial barrier and induces endoplasmic reticulum stress. Knockout of SIRT2 alleviates ileal injury via enhanced autophagy. Autophagy can restore the expression of ZO-1 under stress.
Article
Agriculture, Multidisciplinary
Baoyi Xiong, Wencheng Zhang, Zeyu Wu, Rui Liu, Chengying Yang, Ailing Hui, Xusheng Huang, Zhaojun Xian
Summary: The study demonstrated that okra pectin can attenuate inflammation caused by acute pancreatitis by protecting the intestinal barrier, with OP showing better efficacy than COP. Dietary supplementation of OP could effectively interfere with intestinal damage and attenuate inflammatory responses triggered by AP.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Pharmacology & Pharmacy
Juan Zhang, Xiaoqin Xu, Ning Li, Li Cao, Yu Sun, Junchi Wang, Shuaibing He, Jianyong Si, Degang Qing
Summary: This study investigates the anti-inflammatory effects of licoflavone B (LB) on ulcerative colitis (UC) for the first time. The results show that LB can ameliorate UC by preserving the integrity of the colonic barrier and regulating the composition of the gut microbiota.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Jiaojiao Li, Li Zhang, Tao Wu, Yafei Li, Xiaojun Zhou, Zheng Ruan
Summary: The study demonstrated that indole-3-propionic acid (IPA) can enhance intestinal barrier function by increasing the expression of tight junction and mucin proteins, while decreasing inflammatory factors. This suggests a potential role for gut microbial metabolites of aromatic amino acids in improving intestinal barrier integrity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ya-Nan Gao, Song-Li Li, Xue Yang, Jia-Qi Wang, Nan Zheng
Summary: The study found that lactoferrin (LF) can reduce the increased intestinal permeability caused by aflatoxin M1 (AFM1) and repair the damaged intestinal barrier. In addition, the research revealed that LF acts through regulating multiple pathways related to intestinal cell survival and intestinal integrity. These findings suggest that LF may be a potential option for treating compromised intestinal barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)