Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonio Bianchi, Antonella Giampietro, Alfredo Pontecorvi, Gerald Raverot, Laura De Marinis
Summary: This review provides an overview of the second-line therapies for acromegaly, summarizing the evidence on clinical, molecular, and morphological aspects that can predict the response to these treatments and advocating for a patient-tailored therapeutic approach in clinical practice.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Thierry Brue, Philippe Chanson, Patrice Rodien, Brigitte Delemer, Delphine Drui, Lucile Marie, Laurene Juban, Lara Salvi, Robin Henocque, Gerald Raverot
Summary: The study aimed to estimate the cost-utility of second-line pharmacological treatments in acromegaly patients.
The incremental cost-utility ratios for pasireotide, pegvisomant, and pegvisomant + FGSA were estimated, showing pasireotide to be the least cost-efficient treatment option.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Melin M. Uygur, Stefano Frara
Summary: A personalized approach to acromegaly treatment, utilizing novel clinical and molecular biomarkers, has shown promising results in predicting responsiveness to second-line medical treatments. Integrating these findings into existing guidelines may significantly improve the management of difficult acromegaly patients.
Review
Medicine, General & Internal
Alexandru Dan Popescu, Mara Carsote, Ana Valea, Andreea Gabriela Nicola, Ionela Teodora Dascalu, Tiberiu Tirca, Jaqueline Abdul-Razzak, Mihaela Jana Tuculina
Summary: Acromegaly-related sub/infertility is associated with suboptimal disease control, hyperprolactinemia, hypogonadotropic hypogonadism, and glucose profile anomalies. This review explores the impact of acromegaly on pregnancy outcomes and discusses management strategies. The level of disease control, family history of diabetes, and body mass index are important predictors of maternal complications. Pharmacotherapy has been shown to be safe and effective in improving pregnancy outcomes.
Article
Biochemistry & Molecular Biology
YuanPu Meng, Bo Zhou, Zhe Pei, Ye Chen, Dongmin Chang
Summary: This study investigated the biological properties and mechanisms of growth hormone receptor (GHR) in gastric cancer cells. It was found that GHR can translocate into the nuclei of gastric cancer cells and is closely related to cell proliferation. The GHR inhibitor, pegvisomant, was shown to inhibit both cell proliferation and nuclear localization of GHR, suggesting its potential as a dual-effect antagonist. These findings highlight GHR as a potential target for gastric cancer treatment.
BIOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Fleseriu, Beverly M. K. Biller, Pamela U. Freda, Monica R. Gadelha, Andrea Giustina, Laurence Katznelson, Mark E. Molitch, Susan L. Samson, Christian J. Strasburger, A. J. van der Lely, Shlomo Melmed
Summary: This article focuses on recent advances in the management of acromegaly, emphasizing how key developments affect treatment decisions and outcomes. It also explores the potential role of recently FDA-approved therapies and combination therapies in the treatment arsenal.
Article
Oncology
Ahmed O. Kaseb, Abedul Haque, Deeksha Vishwamitra, Manal M. Hassan, Lianchun Xiao, Bhawana George, Vishal Sahu, Yehia I. Mohamed, Roberto Carmagnani Pestana, Jamie Lynne Lombardo, Rony Avritscher, James C. Yao, Robert A. Wolff, Asif Rashid, Jeffrey S. Morris, Hesham M. Amin
Summary: Hepatocellular carcinoma is an aggressive neoplasm with limited systemic therapy options. This study suggests that growth hormone receptor (GHR) signaling could be a potential therapeutic target for HCC, and pegvisomant may be an effective systemic therapy for this aggressive cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Amit Akirov, Hiba Masri-Iraqi, Idit Dotan, Ilan Shimon
Summary: The diagnosis, management, and treatment of acromegaly heavily rely on the levels of serum IGF-1, basal GH, and nadir GH following OGTT. However, these hormone concentrations can be influenced by various factors, leading to discordant levels that may require additional monitoring and data. New standards for GH and IGF-1 provide more accurate tools, but limitations should be considered along with clinical history and imaging studies when evaluating patients with acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Pamela U. Freda
Summary: Acromegaly is a hormonal disorder characterized by excess hormone production, leading to a specific lipodystrophy and insulin resistance. Understanding the pathophysiology of this condition and its effects on adipose tissue metabolism and insulin resistance is important for optimizing treatment and long-term outcomes for patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
M. Detomas, B. Altieri, J. Flitsch, W. Saeger, M. Korbonits, T. Deutschbein
Summary: This study reports a novel AIP mutation in a German family with acromegaly. It highlights the distinct clinical and histological features of AIP mutated pituitary neuroendocrine tumors and the poor responsiveness to dopamine agonists. Additionally, it emphasizes the increased mortality risk of comorbidities associated with acromegaly.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Li Li, Liheng Meng, Yuping Liu, Rashi Tamrakar, Xi Yang, Xinghuang Liang, Jia Zhou, Jing Xian, Zhenxing Huang, Yingfen Qin
Summary: Mixed pituitary TSH/GH adenomas are rare adenomas that produce both GH and TSH simultaneously, often associated with acromegaly and thyrotoxicosis. Treatment typically involves somatostatin analogs to regulate hormone levels before surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Adriana G. Ioachimescu
Summary: Patients with acromegaly often experience a significant delay between the onset of symptoms and diagnosis, with women and younger patients experiencing longer delays. Comorbidities usually improve after treatment except for irreversible osteoarticular structural changes. Early diagnosis and personalized care are crucial for better management of the condition.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2021)
Article
Gastroenterology & Hepatology
Zichao Yu, Yu Wang, Fang Zhang, Rui Ma, Xiaoyu Yang, Kun Yang, Ai Mi, Liyuan Ran, Yingjie Wu
Summary: Both GH and gut microbiota have significant impacts on physiological processes, and this study found that disruption of GHR in the liver affected gut microbiota and bile acid metabolism, while the influence on adipose tissue was limited. The findings suggest that liver GH signaling plays a crucial role in regulating gut microbiota and may contribute to microbiota-host interaction.
Review
Endocrinology & Metabolism
Artak Labadzhyan, Shlomo Melmed
Summary: Molecular therapeutic targets in growth hormone-secreting adenomas have potential for drug development, including surface receptors recognized by approved drugs and markers for new drug candidates. Current medical therapies control the disease in most patients but the degree of control varies and is related to disease aggressiveness and tumor factors. Understanding the mechanisms behind these molecular markers and their relationship to outcomes holds promise for expanding treatment options and personalized approaches.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Peter Wolf, Sylvie Salenave, Emmanuel Durand, Jacques Young, Peter Kamenicky, Philippe Chanson, Luigi Maione
Summary: The treatment of acromegaly strongly affects body composition until biochemical disease remission, characterized by an increase in fat mass and a decrease in lean mass. These changes are closely associated with the normalization of IGF-I and are independent of individual therapy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joan Gil, Montserrat Marques-Pamies, Elena Valassi, Araceli Garcia-Martinez, Guillermo Serra, Cristina Hostalot, Carmen Fajardo-Montanana, Cristina Carrato, Ignacio Bernabeu, Monica Marazuela, Helena Rodriguez-Lloveras, Rosa Camara, Isabel Salinas, Cristina Lamas, Betina Biagetti, Andreu Simo-Servat, Susan M. Webb, Antonio Pico, Mireia Jorda, Manel Puig-Domingo
Summary: Acromegaly is a condition caused by excessive growth hormone production due to a pituitary tumor. This study examines the relationship between epithelial-mesenchymal transition (EMT) and resistance to somatostatin receptor ligands (SRLs) in GH-producing tumors. The findings suggest that EMT-related gene expression patterns are heterogeneous, which may explain the varying responses to SRLs.
Review
Endocrinology & Metabolism
Dylan J. M. Bergen, Antonio Maurizi, Melissa M. Formosa, Georgina L. K. McDonald, Ahmed El-Gazzar, Neelam Hassan, Maria-Luisa Brandi, Jose A. Riancho, Fernando Rivadeneira, Evangelia Ntzani, Emma L. Duncan, Celia L. Gregson, Douglas P. Kiel, M. Carola Zillikens, Luca Sangiorgi, Wolfgang Hogler, Ivan Duran, Outi Makitie, Wim Van Hul, Gretl Hendrickx
Summary: This article describes 59 high bone mass disorders and their underlying genetic causes, with a focus on the signaling pathways and mechanisms involved. The authors classify the known genes into subgroups based on a uniform Gene Ontology terminology, providing potential insights for experimental design and genetic screening. Additionally, the authors discuss the application of functional genomics in discovering new genes and mechanisms in high bone mass disorders, highlighting the importance of multidisciplinary collaborations and knowledge transfer from the laboratory to the clinic. (c) 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Guillaume Bachelot, Anne Bachelot, Marion Bonnier, Joe-Elie Salem, Dominique Farabos, Severine Trabado, Charlotte Dupont, Peter Kamenicky, Muriel Houang, Jean Fiet, Yves Le Bouc, Jacques Young, Antonin Lamaziere
Summary: A combination of metabolomic signature and machine learning models can distinguish nonclassic 21-hydroxylase deficiency from polycystic ovary syndrome without adrenocorticotrophic hormone testing. A single sampling methodology may be used to exclude the diagnosis of nonclassic 21-hydroxylase deficiency in the presence of a clinical hyperandrogenic presentation at any time of the menstrual cycle. Cosyntropin stimulation remains the gold standard diagnosis of nonclassic 21-hydroxylase deficiency.
HUMAN REPRODUCTION
(2023)
Review
Endocrinology & Metabolism
Susanne Kuckuck, Eline S. van Der Valk, Anton J. W. Scheurink, Bibian van Der Voorn, Anand M. Iyer, Jenny A. Visser, Patric J. D. Delhanty, Sjoerd A. A. van den Berg, Elisabeth F. C. van Rossum
Summary: Disrupted hormonal appetite signaling plays a crucial role in obesity, and glucocorticoid excess may impair appetite signaling and eating control. Counteracting glucocorticoid excess is a crucial target for obesity prevention and treatment, as it can improve appetite signaling and potentially have positive effects on cardio-metabolic outcomes and mood.
Article
Obstetrics & Gynecology
X. Liu, M. Kayser, S. A. Kushner, H. Tiemeier, F. Rivadeneira, V. W. V. Jaddoe, W. J. Niessen, E. B. Wolvius, G. Roshchupkin
Summary: This study found that low-to-moderate levels of prenatal alcohol exposure (PAE) were associated with children's facial shape, even at levels below 12 g of alcohol per week. However, this association diminished as children grew older.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Betina Biagetti, Pedro Iglesias, Rocio Villar-Taibo, Maria-Dolores Moure, Miguel Paja, Marta Araujo-Castro, Jessica Ares, Cristina Alvarez-Escola, Almudena Vicente, Elia Alvarez Guivernau, Iria Novoa-Testa, Fernando Guerrero Perez, Rosa Camara, Beatriz Lecumberri, Carlos Garcia Gomez, Ignacio Bernabeu, Laura Manjon, Sonia Gaztambide, Fernando Cordido, Susan M. Webb, Edelmiro Luis Menendez-Torre, Juan J. Diez, Rafael Simo, Manel Puig-Domingo
Summary: This study compared the clinical characteristics, comorbidities, treatment approaches, and mortality rate of patients diagnosed with acromegaly before or after 2010 and compared the overall mortality rate with the general Spanish population. The results showed no significant difference in mortality rate among acromegaly patients diagnosed at age 65 or older, and no significant difference compared to the general population in Spain.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Rheumatology
Peter Kamenicky, Karine Briot, Maria Luisa Brandi, Martine Cohen-Solal, Rachel K. Crowley, Richard Keen, Sami Kolta, Robin H. Lachmann, Anne-Lise Lecoq, Stuart H. Ralston, Jennifer S. Walsh, Angela J. Rylands, Angela Williams, Wei Sun, Annabel Nixon, Mark Nixon, Muhammad K. Javaid
Summary: The study aimed to report the impact of continued burosumab treatment on clinical laboratory tests, patient-reported outcomes, and ambulatory function in adults with X-linked hypophosphataemia. Results showed that improvements in serum phosphate, serum 1,25 dihydroxyvitamin D, and renal phosphate reabsorption were maintained during the extension period. Additionally, improvements were observed in stiffness and physical function, pain and fatigue symptoms, and ambulatory function.
Article
Endocrinology & Metabolism
Thierry Brue, Haifa Rahabi, Abdoulaye Barry, Anne Barlier, Jerome Bertherat, Francoise Borson-Chazot, Frederic Castinetti, Laure Cazabat, Olivier Chabre, Nicolas Chevalier, Sophie Christin-Maitre, Christine Cortet, Delphine Drui, Peter Kamenicky, Catherine Lancon, Frederic Liote, Isabelle Pellegrini, Rachel Reynaud, Sylvie Salenave, Igor Tauverono, Philippe Tourainep, Marie-Christine Vantyghem, Bruno Verges, Delphine Vezzosi, Chiara Villas, Gerald Raverotd, Regis Coutantt, Philippe Chansonk, Frederique Albarela
Summary: Acromegaly is a rare disease with a slight female predominance and peak onset in adults in the fourth decade. The clinical diagnosis is often delayed due to the slowly progressive onset of symptoms. Multiple clinical criteria define acromegaly, and imaging by pituitary MRI is used to identify the causal tumor for better management. Surgical removal of the tumor is the first-line treatment, with medical treatments used when surgery is not effective. In some cases, acromegaly may be linked to a genetic predisposition.
ANNALES D ENDOCRINOLOGIE
(2023)
Article
Endocrinology & Metabolism
Lionne N. Grootjen, Gwenaelle Diene, Catherine Molinas, Veronique Beauloye, T. Martin Huisman, Jenny A. Visser, Patric J. D. Delhanty, Gerthe F. Kerkhof, Maithe Tauber, Anita C. S. Hokken-Koelega
Summary: Children with Prader-Willi syndrome show a gradual increase in the AG/UAG ratio as they age, with AG levels remaining stable and UAG levels decreasing throughout different nutritional phases. The increase in AG/UAG ratio occurs before the onset of excessive weight gain and hyperphagia in children with PWS.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Neurosciences
Marta Araujo-Castroa, Victor Rodriguez-Berrocalb, Elena Diosc, Ramon Serramitod, Betina e Bernabeuf, e Ignacio Bernabeuf
Summary: Pituitary tumors, accounting for 15% of intracranial tumors, require surgical treatment for hormone hypersecretion and neurological symptoms. Multidisciplinary care is crucial and should be delivered in a center of excellence with a well-defined care protocol.
Article
Respiratory System
Elizabeth Benz, Lies Lahousse, Johnmary T. Arinze, Sara Wijnant, Maria de Ridder, Fernando Rivadeneira, Guy Brusselle, Bruno H. Stricker
Summary: This study aimed to investigate the association between the use of OCS and muscle strength and mass in older people, as well as its interaction with chronic airway diseases. The results showed that OCS use was associated with a decline in handgrip strength in people with COPD, and this association was dependent on the frequency and duration of OCS use.
Article
Endocrinology & Metabolism
Eva Fernandez Rodriguez, Roclo Villar Taibo, Ignacio Bernabeu
Summary: Traumatic brain injury (TBI) is associated with hypopituitarism which can lead to various clinical manifestations. It is important to determine which patients require hormonal evaluation and replacement therapy, as well as the appropriate timing and methods for diagnosis.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2023)
Article
Health Care Sciences & Services
Dolly Yazgi, Carine Richa, Sylvie Salenave, Peter Kamenicky, Amel Bourouina, Lorraine Clavier, Margot Dupeux, Jean-Francois Papon, Jacques Young, Philippe Chanson, Luigi Maione
Summary: Neck ultrasound (US) is a useful tool in distinguishing parathyroid glands (PPGs) from thyroid nodules. This study demonstrates distinct US characteristics of PPGs that can help differentiate them from thyroid nodules. High-risk cervical lesions detected in US may actually be PPGs with similar features.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Annemieke J. M. H. Verkerk, Jeroen van Rooij, Jard de Vries, Ans M. W. van de Ouweland, Maartje J. Hooning, Linda Broer, Willemina R. R. Geurts-Giele, Robert M. van der Helm, Robert M. W. Hofstra, Marieke F. van Dooren, J. Margriet Collee, E. H. Hoefsloot, Andre G. Uitterlinden, Joyce B. van Meurs
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
