Article
Biochemistry & Molecular Biology
Xiangxu Wei, Miao Zhong, Song Wang, Lexun Li, Zi-Long Song, Junmin Zhang, Jianqiang Xu, Jianguo Fang
Summary: The study synthesized 72 disulfides and identified two compounds with significant antitumor activity against HeLa cells. Kinetic studies showed one of the disulfides had faster inhibition of Trx compared to the other. These findings suggest potential for the development of anticancer candidates with Trx inhibition.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyuan Ren, Thierry Leveillard
Summary: The human retina is exposed to reactive oxygen species (ROS) from both internal and external sources, which can cause oxidative stress and lead to damage and cell death. This review focuses on the antioxidant systems in the retina and how they protect against oxidative stress. Both small antioxidants and antioxidant enzymes are involved in the removal of ROS, with the thioredoxin and glutaredoxin systems playing a major role in regulating redox signaling. Additionally, the proteins RdCVFL and TXNIP are involved in metabolic regulation and promoting survival in photoreceptors. Increasing antioxidant capacity in the retina shows promise as a therapy for inherited retinal degeneration.
Article
Agriculture, Multidisciplinary
Xuan Zhang, Yuanyuan Chen, Hongmin Li, Baobao Chen, Zhaojun Liu, Gang Wu, Chengyu Li, Rongyang Li, Yan Cao, Jiaqi Zhou, Ming Shen, Honglin Liu, Jingli Tao
Summary: The study found that Sulforaphane can alleviate the adverse effects of hypoxia on porcine granulosa cells by activating antioxidant defenses and mitophagy through nuclear factor erythroid 2-related factor 2 (NFE2L2).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Neurosciences
Iori Ohmori, Mamoru Ouchida, Hirohiko Imai, Saeko Ishida, Shinya Toyokuni, Tomoji Mashimo
Summary: Thioredoxin plays a critical role in reducing oxidative stress in the central nervous system (CNS). Mutations in the Txn1 gene were found to be associated with CNS degeneration and decreased insulin activity. Txn1 was shown to be involved in regulating oxidative stress in the midbrain with high energy metabolism, and neuronal death was observed in mutant rats.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Junmin Zhang, Xinming Li, Zhengjia Zhao, Wenqing Cai, Jianguo Fang
Summary: This article reviews the importance of thioredoxin (Trx) in regulating cancer-related signaling pathways and its potential therapeutic opportunities. Research has shown that Trx participates in multiple signaling pathways that influence cancer development and treatment by modulating the dynamic changes in protein structure and function. Future research directions include further exploring Trx-related signaling pathways and their upstream and downstream regulatory proteins, as well as developing novel anticancer drugs targeting the Trx signaling pathways.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Ophthalmology
Tae Kyeom Kang, Tam Thi Le, Kyung-A Kim, Young-Joo Kim, Wook-Bin Lee, Sang Hoon Jung
Summary: Lithospermum erythrorhizon has potent wound healing, antiinflammatory, and antioxidant properties. Extracts from this plant have been shown to protect retinal cells in vitro and in vivo, with lithospermic acid A identified as a key compound responsible for its antioxidant effects. This suggests that Lithospermum erythrorhizon could be a beneficial agent for treating retinal degenerative diseases such as glaucoma.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dan Shao, Zhen Gao, Ying Zhao, Mingzhen Fan, Xiaoe Zhao, Qiang Wei, Menghao Pan, Baohua Ma
Summary: Oxidative stress in high-yielding dairy goats negatively affects lactation length, milk quality, and dairy product economics. Sulforaphane (SFN), found in broccoli, shows promise as an antioxidant for clinical applications. This study investigated the effects of SFN on H2O2-induced oxidative damage in GMECs and the underlying molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hye In Kim, Seok Kyo Seo, Seung Joo Chon, Ga Hee Kim, Inha Lee, Bo Hyon Yun
Summary: SAHA induces apoptosis in human endometrial cells by modulating the TRX/TBP-2 system, showing potential as a therapeutic agent for endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Ilaria Piano, Mattia Di Paolo, Francesca Corsi, Eugenia Piragine, Silvia Bisti, Claudia Gargini, Stefano Di Marco
Summary: Research has shown that retinal diseases can be caused by a variety of factors, with treatments still needing improvement, especially in the case of gene therapy. Current studies are mostly focused on animal models, with challenges in progressing to human clinical trials. By studying the treatment outcomes in different animal models, the effectiveness of each therapy can be better evaluated.
Article
Medicine, Research & Experimental
Ana Carolina B. da C. Rodrigues, Larissa M. Bomfim, Sara P. Neves, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Emmanoel V. Costa, Felipe M. A. da Silva, Waldireny C. Rocha, Hector H. F. Koolen, Daniel P. Bezerra
Summary: Tingenone (TG) and 22-hydroxytingenone (22-HTG) are quinonemethide triterpenes from the Amazonian plant Salacia impressifolia, showing potent cytotoxicity against AML HL-60 cell line through apoptosis pathway mediated by oxidative stress. These compounds are potential candidates for anti-AML therapy targeting thioredoxin.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Wei-Jian Li, Xuan Zhang, Ming Shen, Hong-Lin Liu, Li-Ren Ding
Summary: This study investigated the cytotoxicity of 3-Nitropropionic acid (3-NP) during mouse oocyte maturation and the protective effects of Sulforaphane (SFN). The results showed that 3-NP inhibited oocyte maturation in a dose-dependent manner, while SFN significantly alleviated the defects caused by 3-NP. In addition, 3-NP disrupted mitochondrial functions in oocytes, leading to oxidative stress and increased apoptosis. SFN supplementation had significant cytoprotective effects, mitigating these damages.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junmin Zhang, Zai-Qin Zheng, Qianhe Xu, Ya Li, Kun Gao, Jianguo Fang
Summary: The study identifies a new natural product, onopordopicrin (ONP), which inhibits thioredoxin reductase leading to disruption of cellular redox balance and promotion of oxidative stress. ONP shows the highest potency in killing cancer cells, with its inhibitory effect on TrxR closely correlated with cytotoxicity.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Guang-Ping Zou, Tao Wang, Jin-Xing Xiao, Xiao-Yu Wang, Li-Ping Jiang, Fang-Fang Tou, Zhi-Ping Chen, Xin-Hui Qu, Xiao-Jian Han
Summary: Age-related macular degeneration, a common cause of blindness in the elderly, is primarily attributed to oxidative stress and dysregulated autophagy in retinal pigment epithelium cells. Lactate has been found to act as a signaling molecule that protects against oxidative stress. This study aimed to investigate the protective effect of lactate against oxidative stress-induced retinal degeneration. The results showed that lactate alleviated oxidative stress-induced cell death and retinal degeneration by activating autophagy and preserving mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jinjin Pan, Rui Wang, Yandong Pei, Dingyou Wang, Na Wu, Yuke Ji, Qing Tang, Liang Liu, Ke Cheng, Qiwang Liu, Jian Sun, Miaomiao Gong, Xu Zheng, Junxia Li, Changlin Zhang, Yuhui Yuan
Summary: This study aimed to investigate the effect and mechanism of sulforaphane (SFN) on hypoxic pulmonary hypertension (HPH). The results showed that SFN could inhibit the progression of HPH, reduce inflammation and oxidative stress, and promote apoptosis in pulmonary artery smooth muscle cells (PASMCs) under hypoxia conditions. SFN also prevented the apoptosis of pulmonary microvascular endothelial cells (ECs). These findings suggest that SFN has potential therapeutic effects on HPH by improving pulmonary vascular remodeling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Daowei Zhang, Jiawen Wu, Jihong Wu, Shenghai Zhang
Summary: The study found that Pae treatment can reduce apoptosis of LD-induced RP cells and increase cell viability and autophagy in 661W cells. Pae enhances cell antioxidant capacity and protects retinal function by regulating autophagy pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)