Article
Multidisciplinary Sciences
Ariane Menden, Davane Hall, Coral Hahn-Townsend, Courtney A. Broedlow, Utsav Joshi, Andrew Pearson, Fiona Crawford, James E. Evans, Nichole Klatt, Stefan Crynen, Michael Mullan, Ghania Ait-Ghezala
Summary: This study found that altered gut microbial composition is associated with the development of AD, and treatment with CRL can rebalance the gut microbiome and reduce AD pathology. The study also demonstrated that fecal matter transplant can alleviate memory deficits. These findings provide new insights into improving AD neuropathology.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Julio Rea Martinez, Gordana Selo, Maria Angeles Fernandez-Arche, Beatriz Bermudez, Maria Dolores Garcia-Gimenez
Summary: Compounds from hempseed have shown beneficial effects on neuro-inflammation and can inhibit the expression of genes involved in the accumulation of Aβ plaques. These compounds also positively affect transcription factors related to complex biological functions.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Multidisciplinary Sciences
Neeraj Singh, Marc R. Benoit, John Zhou, Brati Das, Jose Davila-Velderrain, Ma Nolis Kellis, Li-Huei Tsai, Xiangyou Hu, Riqiang Yan
Summary: BACE-1 plays a role in regulating the transition of microglia in Alzheimer's disease. Deficiency of BACE-1 leads to increased expression of certain transcription factors involved in the transition from homeostatic to highly phagocytic microglia. Similar transition-state microglia in AD brains are associated with decreased levels of BACE-1 expression.
Article
Food Science & Technology
Hyunuk Kang, Hui Zhou, Yushan Ye, Jiangfan Yang, Zhonghua Liu, Puming He, Bo Li, Yuanyuan Wu, Yaomin Wang, Youying Tu
Summary: Tieguanyin tea extracts have positive effects on the cognitive ability and neuroprotection of APP/PS1 mice by alleviating inflammation and improving antioxidant capacity.
Article
Chemistry, Multidisciplinary
Chunyuan Zhang, Zeting Xing, Meiyun Tan, Yanwen Wu, Wei Zeng
Summary: The study revealed that roflumilast could alleviate isoflurane-induced neuroinflammation in astrocytes through the CREB/BDNF signaling pathway, demonstrating a significant protective effect.
Article
Biochemistry & Molecular Biology
Nipun Chopra, Ruizhi Wang, Bryan Maloney, Kwangsik Nho, John S. Beck, Naemeh Pourshafie, Alexander Niculescu, Andrew J. Saykin, Carlo Rinaldi, Scott E. Counts, Debomoy K. Lahiri
Summary: The study found that miR-298 may have potential therapeutic effects on Alzheimer's disease by inhibiting the expression of key proteins and influencing posttranslational levels of tau protein. This research opens up new possibilities for miR-298 to become a target for Alzheimer's disease therapy.
MOLECULAR PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Sarah A. Abd El-Aal, Hanan S. El-Abhar, Yasmin S. Abulfadl
Summary: This study revealed the potential anticonvulsant and neuroprotective effects of morin in a rat epilepsy model, highlighting its promising role in the management of epilepsy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Hong-Hua Song, Tian-Cheng Song, Ting Yang, Chun-Shuai Sun, Bing-Qiang He, Hui Li, Ying-Jie Wang, Yu Li, Hao Wu, Yu-Ming Hu, Yong-Jun Wang
Summary: The study demonstrates that HMGB1 mediates the astrocyte inflammatory response through regulating the COX2/PGE2 signaling pathway.
NEURAL REGENERATION RESEARCH
(2021)
Article
Neurosciences
Tee Jong Huat, Tessa Onraet, Judith Camats-Perna, Estella A. Newcombe, Kim C. Ngo, Ashley N. Sue, Mehdi Mirzaei, Frank M. LaFerla, Rodrigo Medeiros
Summary: This study reveals that MyD88 plays a pivotal role in the regulation of astrocyte response to Alzheimer's disease (AD), with upregulated expression in AD patients. Deletion of astrocytic MyD88 protects mice from acute synaptic toxicity and cognitive impairment caused by beta-amyloid. Loss of astrocytic MyD88 results in altered astrocyte reactivity, lower levels of immune-related proteins, and higher expression of synaptic-related proteins in response to beta-amyloid.
Article
Biochemical Research Methods
Richa Arya, Sarvesh Paliwal, S. P. Gupta, Swapnil Sharma, Kirtika Madan, Achal Mishra, Kanika Verma, Neha Chauhan
Summary: In this study, a pharmacophore model was developed for designing new BACE-1 inhibitors with a high correlation coefficient and low root mean square deviation. Docking interactions showed two compounds binding effectively to the BACE-1 receptor, with one compound exhibiting the highest docking score. In vitro assay confirmed the high biological activity of these compounds.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Neurosciences
Genghuan Wang, Jian Shen, Liping Zhai, Yingcong Lin, Qiaobing Guan, Heping Shen
Summary: The study investigated the mechanism of how TL1A mediates the A1 differentiation of astrocytes in POCD. TL1A was found to promote the progression of cognitive dysfunction in mice. Knockout of NLRP3 or intervention with NLRP3 inhibitor could inhibit the effect of TL1A, improving cognitive dysfunction and suppressing A1 differentiation.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Adrian Jorda, Martin Aldasoro, Ignacio Campo-Palacio, Jose M. Vila, Constanza Aldasoro, Juan Campos-Campos, Carlos Colmena, Sandeep Kumar Singh, Elena Obrador, Soraya L. Valles
Summary: Rn facilitates the effects of insulin on the p-AKT, p-eNOS, p-ERK, Mn-SOD, and PPAR-gamma signaling pathways, as well as on the anti-inflammatory and antioxidant effects of the hormone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Neeraj Singh, Brati Das, John Zhou, Xiangyou Hu, Riqiang Yan
Summary: This study demonstrates that targeted inhibition of BACE-1 in microglia has unique advantages in the treatment of Alzheimer's disease, including reducing amyloid plaque formation, enhancing Aβ clearance, and promoting the functions of autophagolysosomes and Aβ-induced metabolic reprogramming.
Article
Cell Biology
Diana M. Bessa de Sousa, Ariane Benedetti, Barbara Altendorfer, Heike Mrowetz, Michael S. Unger, Katharina Schallmoser, Ludwig Aigner, Kathrin Maria Kniewallner
Summary: In Alzheimer's disease, dysfunctional platelets may contribute to amyloid beta deposition. Platelet depletion in APP-PS1 transgenic mice led to an increase in amyloid plaque size distribution and neuritic dystrophy in the hippocampus of female mice. It was found that platelet-depleted females had lower amounts of amyloid beta cargo and increased overlap between astrocytic processes and amyloid plaques. These findings suggest that platelets might limit plaque growth and reduce plaque-related neuritic dystrophy at advanced stages of amyloid plaque pathology in APP-PS1 female mice.
Article
Neurosciences
Edward Pajarillo, Ivan Nyarko-Danquah, Alexis Digman, Cynthia Vied, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Lee
Summary: The transcription factor YY1 in astrocytes plays a critical role in brain development, locomotor activity, motor coordination, and cognition. Deletion of astrocytic YY1 results in abnormal phenotypes, movement deficits, and cognitive dysfunction, as well as changes in inflammatory and oxidative stress responses.
Article
Biochemistry & Molecular Biology
Eliezer Joseph, Daniel Miguel Angel Villalobos-Acosta, Monica Adriana Torres-Ramos, Eunice Dalet Farfan-Garcia, Modesto Gomez-Lopez, Angel Miliar-Garcia, Manuel Jonathan Fragoso-Vazquez, Iohanan Daniel Garcia-Marin, Jose Correa-Basurto, Martha Cecilia Rosales-Hernandez
JOURNAL OF MOLECULAR NEUROSCIENCE
(2020)
Article
Immunology
Gwendolyne Mendez-Frausto, Marina Nayeli Medina-Rosales, Edith Elena Uresti-Rivera, Lourdes Baranda-Candido, Martin Zapata-Zuniga, Yadira Bastian, Roberto Gonzalez Amaro, Jose Antonio Enciso-Moreno, Mariana Haydee Garcia-Hernandez
Article
Biochemistry & Molecular Biology
Magnolia Estrada-Rivera, Miguel Angel Hernandez-Onate, Mitzuko Dautt-Castro, Jose de Jesus Gallardo-Negrete, Oscar Guillermo Rebolledo-Prudencio, Edith Elena Uresti-Rivera, Catalina Arenas-Huertero, Alfredo Herrera-Estrella, Sergio Casas-Flores
MOLECULAR PLANT-MICROBE INTERACTIONS
(2020)
Article
Biochemistry & Molecular Biology
Nicte Alaide Ramos-Garcia, Marisol Orozco-Ibarra, Enrique Estudillo, Guillermo Elizondo, Erick Gomez Apo, Laura Graciela Chavez Macias, Ana Luisa Sosa-Ortiz, Monica Adriana Torres-Ramos
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Francisco L. Ramirez-Cuapio, Monica A. Torres-Ramos, Marisol Orozco-Ibarra, Isaac Acosta, Ana L. Sosa-Ortiz
Summary: The study found that serum REST levels are not a viable blood-based biomarker for Alzheimer's disease, and are not associated with disease severity and comorbidities.
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
(2021)
Article
Chemistry, Analytical
Oswaldo Hernandez-Gonzalez, Sergio Zarazua, Jose Ignacio Veytia-Bucheli, Marco Martin Gonzalez-Chavez, Cristian Jazmin Rodriguez-Pinal, Susanna Edith Medellin-Garibay, Edith Elena Uresti-Rivera, Francisco Javier Perez-Vazquez, Diana Patricia Portales-Perez, Silvia Romano-Moreno, Rosa del Carmen Milan-Segovia
Summary: This study developed and validated an alternative high-performance liquid chromatography method for simultaneous quantification of four antituberculosis drugs in plasma of patients. The method showed linearity, precision, and accuracy, and could be applied for therapeutic drug monitoring and pharmacokinetics studies throughout tuberculosis treatment.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Endocrinology & Metabolism
G. Mendez-Frausto, G. Romero-Aguilera, R. Sanchez-Gutierrez, R. E. Garcia-Jacobo, E. E. Lara-Ramirez, E. E. Uresti-Rivera, R. Gonzalez-Amaro, J. A. Enciso-Moreno, M. H. Garcia-Hernandez
Summary: The study observed increased levels of IL-6, IL-17+ and IL-17 + IFN-gamma+ T cells, and decreased levels of IL-10 and CD19 + IL-10+ cells in T2DM patients. The percentages of CD19 + CD24 + CD38+ cells were associated with HOMA-B, TyG index, HDL, and cholesterol values. In normal-glycemic individuals, CD19 + CD24 + CD27+ cells were inversely associated with triglycerides and TyG index.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Oncology
Eneida Turijan-Espinoza, Victor Manuel Ruiz-Rodriguez, Edith Elena Uresti-Rivera, Ernesto Martinez-Leija, Jose De Jesus Zermeno-Nava, Arturo Guel-Panola, Silvia Romano-Moreno, Juan Manuel Vargas-Morales, Diana Patricia Portales-Perez
Summary: The study showed a significant association between ABCB1 gene SNP (C3435T) and clinical response to FAC neoadjuvant chemotherapy in breast cancer patients, while polymorphisms in ABCG2 gene were not correlated with chemoresistance.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Pathology
G. Mendez-Frausto, E. E. Uresti-Rivera, S. Godina-Gonzalez, D. P. Portales-Perez, R. Gonzalez-Amaro, M. H. Garcia-Hernandez
Summary: This study aimed to analyze the expression of CRAMP, mBD-3, mBD-4, and MMP-3 in different phases of CIA in mice and their association with IL-10, IL-4, IFN-gamma, IL-17, RANK/RANKL/OPG. The results suggest that CRAMP plays a crucial role in CIA progression and may contribute to bone reconstruction in the late stage of the disease. The study also revealed complex interactions between various molecules and cytokines in the pathogenesis of CIA.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
E. E. Uresti-Rivera, G. Mendez-Frausto, M. N. Medina-Rosales, J. Ventura-Juarez, M. H. Garcia-Hernandez
Summary: This study evaluated the modulation of regulatory T cell differentiation by sodium selenite. The results showed that sodium selenite reversibly affects T cell differentiation, increases immune response, and regulates the expression of suppressor molecules.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Manuel F. Giraldo-Velasquez, Ivan N. Perez-Osorio, Alejandro Espinosa-Ceron, Brandon M. Barcena, Arturo Calderon-Gallegos, Gladis Fragoso, Monica Torres-Ramos, Nayeli Paez-Martinez, Edda Sciutto
Summary: Inhalants, including toluene, can induce neuroinflammation and histological damages, but intranasally administered methylprednisolone treatment can reverse these damages.
Review
Immunology
E. E. Uresti-Rivera, M. H. Garcia-Hernandez
Summary: The inflammasome AIM2 plays a critical role in regulating innate immune functions and inflammatory responses. Its activation leads to the production of pro-inflammatory cytokines and counteracting excessive cell proliferation. Deregulated AIM2 activation contributes to the pathogenesis of inflammatory diseases.
Article
Cell Biology
Daniel Cuervo-Zanatta, Tauqeerunnisa Syeda, Vicente Sanchez-Valle, Mariangel Irene-Fierro, Pablo Torres-Aguilar, Monica Adriana Torres-Ramos, Mineko Shibayama-Salas, Angelica Silva-Olivares, Lilia G. Noriega, Nimbe Torres, Armando R. Tovar, Ivan Ruminot, L. Felipe Barros, Jaime Garcia-Mena, Claudia Perez-Cruz
Summary: Fiber intake is associated with a lower risk for Alzheimer's disease in older adults. The neuroprotective effects of fiber intake may depend on the modulation of gut microbiota dysbiosis and specific actions of short-chain fatty acids in brain cells.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Martha Cecilia Rosales-Hernandez, Martiniano Bello, Jazziel Velazquez Toledano, Barbara Citlali Escudero Feregrino, Jose Correa Basurto, Leticia Guadalupe Fragoso Morales, Monica Adriana Torres-Ramos
Summary: The 3D structure of the aryl hydrocarbon receptor (AhR) was studied using in silico methods. Molecular dynamics simulations revealed that HSP90 interacts with AhR when agonists bind, but not when antagonists bind. This study provides insights into the activity and interactions of AhR.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Raul Horacio Camarillo-Lopez, Maricarmen Hernandez Rodriguez, Monica Adriana Torres-Ramos, Ivonne Maciel Arciniega-Martinez, Iohanan Daniel Garcia-Marin, Jose Correa Basurto, Juan Vicente Mendez Mendez, Martha Cecilia Rosales-Hernandez