期刊
NEUROCASE
卷 22, 期 5, 页码 416-425出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/13554794.2016.1215469
关键词
Bilateral arm training; robot; stroke; neuroplasticity; dynamic causal model (DCM)
资金
- National Health Research Institutes [NHRI-EX103-10010PI]
- Ministry of Science and Technology [100-2314-B-002-008-MY3, 102-2314-B-002-154-MY2, 102-2628-B-182-005 -MY3]
- Healthy Ageing Research Center at Chang Gung University [EMRPD1D0291, CMRPD1B0331]
- Chang Gung Memorial Hospital [CMRPD 1C0402]
- Excellent Research Projects of National Taiwan University in Taiwan
Robot-assisted bilateral arm therapy (RBAT) has shown promising results in stroke rehabilitation; however, connectivity mapping of the sensorimotor networks after RBAT remains unclear. We used fMRI before and after RBAT and a dose-matched control intervention (DMCI) to explore the connectivity changes in 6 subacute stroke patients. Sensorimotor functions improved in the RBAT and DMCI groups after treatment. Enhanced activation changes were observed in bilateral primary motor cortex (M1) and bilateral supplementary motor area (SMA) after RBAT. Dynamic causal model analysis revealed that interhemispheric connections were enhanced in RBAT patients. These preliminary findings suggest that intracortical and intercortical coupling might underlie poststroke RBAT.
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