Article
Biochemistry & Molecular Biology
Igor Splichal, Alla Splichalova
Summary: Intra-amniotic infections can lead to preterm birth, with HMGB1 playing a role in inflammatory responses. In a study infecting a pig's amniotic fluid with E. coli O55, HMGB1 expression and release were altered, along with changes in RAGE and TLR4 expression levels. Targeting HMGB1 may have potential therapeutic benefits in preventing preterm birth.
Review
Biochemistry & Molecular Biology
Matthew Snelson, Elisa Lucut, Melinda T. Coughlan
Summary: There is increasing evidence for the role of intestinal permeability in the pathogenesis of diabetes, and the binding of advanced glycation endproducts to RAGE receptor may trigger proinflammatory signaling cascade, leading to intestinal inflammation and increased permeability, thus contributing to the development of diabetes complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Haruki Watanabe, Myoungsun Son
Summary: The review examines the roles of HMGB1 and RAGE in controlling inflammation and immune tolerance, highlighting the dual effects of the HMGB1-RAGE axis in driving inflammation and its potential anti-inflammatory effects. The discussion also touches on how RAGE heterodimers respond to microenvironments in immune responses.
Article
Food Science & Technology
Qian Wu, Yingna Feng, Yu Ouyang, Yinggang Liang, Kuoquan Zhao, Ying Wang, Qing Luo, Juan Xiao, Nianjie Feng, Mengzhou Zhou
Summary: The study demonstrated that LSOPC inhibited AGEs formation, alleviated AGEs-induced liver injury by suppressing NF-kappa B nuclear translocation and MAPK signaling pathway activation. Additionally, LSOPC also inhibited the expression of TNF-alpha and IL-6. In conclusion, LSOPC treatment potentially modulated liver injury caused by long-term dietary AGEs by suppressing the RAGE-MAPK-NF-kappa B pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Article
Medicine, Research & Experimental
Fumiaki Sato, Yoki Nakamura, Simeng Ma, Takahiro Kochi, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Norimitsu Morioka
Summary: This study investigated the role of central HMGB1 in regulating nociceptive hypersensitivity in a mouse model of PD. The findings suggest that HMGB1 is involved in maintaining nociceptive symptoms in hemi-PD mice via spinal microglial activation, indicating its potential as a therapeutic target for pain associated with PD.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Grit Elster Legaard, Mark Preben Printz Lyngbaek, Thomas Peter Almdal, Cody Garett Durrer, Ulrikke Nystrup, Emil List Larsen, Henrik Enghusen Poulsen, Kristian Karstoft, Bente Klarlund Pedersen, Mathias Ried-Larsen
Summary: This study aimed to investigate the effects of different volumes of exercise in adjunct to diet-induced weight loss and standard care on advanced glycation end-products (AGEs) and receptor for AGE (RAGE). The results showed that exercise in adjunct to diet-induced weight loss did not change the levels of sRAGE in persons living with well-regulated, short standing type 2 diabetes.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Julio A. Lamprea-Montealegre, Alice M. Arnold, Robyn L. McCLelland, Kenneth J. Mukamal, Luc Djousse, Mary L. Biggs, David S. Siscovick, Russell P. Tracy, Paul J. Beisswenger, Bruce M. Psaty, Joachim H. Ix, Jorge R. Kizer
Summary: This study found that alpha-dicarbonyl-derived AGEs are associated with CVD in an older cohort, but not in a healthier middle-aged/older cohort. The results suggest that AGEs may exert detrimental cardiovascular effects only under conditions of marked dicarbonyl and oxidative stress. Further investigation of alpha-dicarbonyl derivatives could lead to potential new strategies for CVD prevention in high-risk older populations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Chemistry, Physical
Vaishali Rana, Ahana Mukherjee, Yogita Basnal, Deepak Kushwaha, Jaydeep Bhattacharya, Ranjita Ghosh Moulick
Summary: The elevated blood sugar in Type II diabetes leads to the formation of Advanced Glycation Endproducts (AGEs), which cause severe pathogenic complications. Previous research has shown that AGEs generated from Hemoglobin A0 (HbA0) can synthesize gold nanoparticles (AuNPs). In this study, it was found that these AGEs can also reduce silver ions and synthesize silver nanoparticles (AgNPs) with a different plasmonic response. The research demonstrates that AGEs can be detected by deploying metal salts in solution.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Oncology
Ana-Lucia Mayen, Elom K. Aglago, Viktoria Knaze, Reynalda Cordova, Casper G. Schalkwijk, Karl-Heinz Wagner, Krasimira Aleksandrova, Veronika Fedirko, Pekka Keski-Rahkonen, Michael F. Leitzmann, Verena Katzke, Bernard Srour, Matthias B. Schulze, Giovanna Masala, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Bas Bueno-de-Mesquita, Magritt Brustad, Antonio Agudo, Maria Dolores Chirlaque Lopez, Pilar Amiano, Bodil Ohlsson, Stina Ramne, Dagfinn Aune, Elisabete Weiderpass, Mazda Jenab, Heinz Freisling
Summary: The study found that higher dietary intake of AGEs was inversely associated with the risk of hepatocellular carcinoma and positively associated with the risk of gallbladder cancer. No associations were observed for cancers of the intra and extrahepatic bile ducts.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Physiology
Xiaoxia Huang, Bingyu Li, Jiaqing Hu, Zhuanhua Liu, Dongping Li, Zhenfeng Chen, Hang Huang, Yanjia Chen, Xiaohua Guo, Yun Cui, Qiaobing Huang
Summary: This study reveals that AGEs mediate kidney injury with characteristic patterns by binding with RAGE and inducing moesin phosphorylation. AGE-BSA stimulation in mice resulted in distinct abnormal angiogenesis, glomerular hypertrophy, mesangial expansion, glomerular atrophy, and fibrosis at different time points. Moesin phosphorylation was accompanied by these AGE-induced alterations, and moesin deficiency attenuated AGE-BSA-induced fibrosis. The phosphorylation of moesin T558 was critical in AGE-induced tube formation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
William A. Banks, Kim M. Hansen, Michelle A. Erickson, Fulton T. Crews
Summary: High-mobility group box 1 (HMGB1) is a protein that regulates transcription in the cell nucleus and activates the innate immune system. It can cross the blood-brain barrier (BBB) and affect neuroimmune signaling in the brain and periphery. In this study, the ability of radioactively labeled HMGB1 to cross the BBB was examined. The results showed that HMGB1 could bidirectionally cross the BBB and its transport rates were enhanced by inflammation. This finding suggests that HMGB1 levels have an impact on neuroimmune signaling in various conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Pharmacology & Pharmacy
Yakun Li, Bingyang Xu, Jun Yang, Lu Wang, Xiaosheng Tan, Xiaofan Hu, Lingjuan Sun, Song Chen, Lan Zhu, Xiaoping Chen, Gang Chen
Summary: Liraglutide exerts protective effects against renal ischemia-reperfusion injury by inhibiting HMGB1 nuclear-cytoplasmic translocation and release, partially dependent on GLP-1R. This demonstrates its therapeutic potential in the prevention and treatment of organ IRI.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Marta Francisca Corra, Nuno Vila-Cha, Ana Sardoeira, Clint Hansen, Ana Paula Sousa, Ines Reis, Firmina Sambayeta, Joana Damasio, Margarida Calejo, Andreas Schicketmueller, Ines Laranjinha, Paula Salgado, Ricardo Taipa, Rui Magalhaes, Manuel Correia, Walter Maetzler, Luis F. Maia
Summary: Peripheral neuropathy is common in Parkinson's disease patients and has a negative impact on gait and balance.
Article
Medicine, Research & Experimental
Agnes Langer, Lara Lucke-Paulig, Lucia Gassner, Rejko Krueger, Daniel Weiss, Alireza Gharabaghi, Heidemarie Zach, Walter Maetzler, Markus A. Hobert
Summary: This study compared the effects of deep brain stimulation and dopaminergic medication on gait parameters in patients with advanced Parkinson disease. The results showed that dopaminergic medication had larger additional effects on gait parameters under both single-tasking and dual-tasking conditions, while deep brain stimulation only improved specific gait parameters.
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Article
Geriatrics & Gerontology
Markus A. Hobert, Daniel Bruhn, Jakob Koch, Simone Studt
Summary: This case report describes the successful treatment of an 82-year-old patient with a multifactorial gait disorder and falls in a gerontological psychiatric ward. The patient's gait disorder, mainly caused by depression and fear of falling, improved significantly with a multimodal treatment approach that included electroconvulsive therapy (ECT).
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
(2023)
Article
Medicine, General & Internal
Constanze Stolz-Klingenberg, Claudia Buenzen, Marie Coors, Charlotte Flueh, Klarissa Hanja Stuerner, Kai Wehkamp, Marla L. Clayman, Fueloep Scheibler, Jens Ulrich Rueffer, Wiebke Schuettig, Leonie Sundmacher, Daniela Berg, Friedemann Geiger
Summary: SHARE TO CARE (S2C) is a comprehensive program aimed at promoting shared decision making (SDM). It has been successfully implemented at the University Hospital Schleswig-Holstein in Kiel, Germany, and among general practitioners in the Federal State of Bremen. The results of the implementation showed an increase in patients' perceived involvement in medical decision making.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Chemistry, Analytical
Clint Hansen, Baraah Chebil, John Cockroft, Edoardo Bianchini, Robbin Romijnders, Walter Maetzler
Summary: This study collected skeletal kinematics data from 21 healthy participants and 24 neurogeriatric participants using wearable sensors and an accelerometer-based functional calibration method. The study found that IMU-based parameters significantly correlated with the SPPB score and showed significant differences between SPPB subgroups. Lower limb range of motion and joint segment coordination were positively correlated with the SPPB score, while segment coordination variability was negatively correlated.
Letter
Clinical Neurology
Christos Koros, Kathrin Brockmann, Athina-Maria Simitsi, Anastasia Bougea, Hui Liu, Ann-Kathrin Hauser, Claudia Schulte, Stefanie Lerche, Ioanna Pachi, Nikolaos Papagiannakis, Roubina Antonelou, Athina Zahou, Isabel Wurster, Efthymia Efthymiopoulou, Ion Beratis, Matina Maniati, Marina Moraitou, Helen Michelakakis, Georgios Paraskevas, Sokratis G. Papageorgiou, Constantin Potagas, Dimitra Papadimitriou, Maria Bozi, Maria Stamelou, Thomas Gasser, Leonidas Stefanis
MOVEMENT DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Lydia Kastner, Ulrike Suenkel, Gerhard W. Eschweiler, Theresa Dankowski, Anna-Katharina von Thaler, Christian Mychajliw, Kathrin Brockmann, Walter Maetzler, Daniela Berg, Andreas J. Fallgatter, Sebastian Heinzel, Ansgar Thiel
Summary: Older age is a major risk factor for severe COVID-19. In 2020, there was a broad political debate on whether older adults need special protection and isolation to minimize their risk of SARS-CoV-2 infection. However, isolation may also have indirect negative psychological or physical consequences depending on individual coping strategies and personality traits.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Respiratory System
Joren Buekers, Dimitrios Megaritis, Sarah Koch, Lisa Alcock, Nadir Ammour, Clemens Becker, Stefano Bertuletti, Tecla Bonci, Philip Brown, Ellen Buckley, Sara C. Buttery, Brian Caulfied, Andrea Cereatti, Nikolaos Chynkiamis, Heleen Demeyer, Carlos Echevarria, Anja Frei, Clint Hansen, Jeffrey M. Hausdorff, Nicholas S. Hopkinson, Emily Hume, Arne Kuederle, Walter Maetzler, Claudia Mazza, Encarna M. Mico-Amigo, Arne Mueller, Luca Palmerini, Francesca Salis, Kirsty Scott, Thierry Troosters, Beatrix Vereijken, Henrik Watz, Lynn Rochester, Silvia Del Din, Ioannis Vogiatzis, Judith Garcia-Aymerich
Summary: Gait impairment in adults with mild-to-severe COPD mainly manifests during longer free-living walking bouts (>30 s). Walking speed and cadence are significantly slower in COPD adults compared to healthy controls during longer free-living walking bouts, but not during shorter walking bouts. Double support duration and gait variability measures are generally comparable between the two groups.
Meeting Abstract
Clinical Neurology
R. Yilmaz, R. Wolke, N. Puls, M. Sorgun, G. Deuschl, D. Berg, N. Margraf
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
C. Zatti, A. Pilotto, A. Rizzardi, M. Catania, L. Purin, M. Pasolini, C. Hansen, R. Romijnders, E. Schaeffer, A. Galbiati, L. Ferini Strambi, D. Berg, W. Maetzler, A. Padovani
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
A. Kluge, E. Schaeffer, K. Brockmann, C. Schulte, C. Deuschle, J. Bunk, W. Maetzler, D. Berg
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
I. Liepelt-Scarfone, M. Bode, S. Solbrig, K. Brockmann, W. Maetzler, I. Wurster, M. Timmers, D. Berg, S. Becker
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
S. Paschen, J. Becktepe, M. Hobert, K. Zeuner, A. Helmers, D. Berg, G. Deuschl
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
S. Becker, O. Granert, C. Schulte, K. Brockmann, B. Roeben, M. Bode, M. Timmers, K. Scheffler, W. Maetzler, D. Berg, I. Liepelt-Scarfone
MOVEMENT DISORDERS
(2023)