Article
Biochemistry & Molecular Biology
Nina I. Uspalenko, Alexei A. Mosentsov, Natalia V. Khmil, Lyubov L. Pavlik, Natalia V. Belosludtseva, Natalia V. Khunderyakova, Maria I. Shigaeva, Vasilisa P. Medvedeva, Anton E. Malkov, Valentina F. Kitchigina, Galina D. Mironova
Summary: Uridine has a protective effect on Parkinson's disease and activates the mitoK-ATP channel. It can restore mitochondrial damage, oxidative stress, and increased lactate dehydrogenase activity induced by PD. The protective effect of uridine is closely related to the mitoK-ATP channel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Victor Silva da Fonseca, Valeria de Cassia Goncalves, Mario Augusto Izidoro, Antonio-Carlos Guimaraes de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza
Summary: Parkinson's disease is an incurable neurodegenerative disease with an increasing global disability and mortality rate. Non-motor symptoms are the main cause of disability and decreased quality of life. This study used metabolomics to assess changes in cardiac metabolism in a PD model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Samir Kumar Beura, Pooja Yadav, Abhishek Ramachandra Panigrahi, Sunil Kumar Singh
Summary: Parkinson's disease (PD) is associated with cardiovascular complications, and platelets are believed to play a crucial role in regulating these complications. A study found that treatment with 6-OHDA increases reactive oxygen species (ROS) production in human blood platelets, which is regulated by the IP3 receptor-Ca2+-NOX signaling axis. These findings provide important insights into the altered platelet activities observed in PD patients.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Ying Lyu, Yiying Huang, Guiying Shi, Xuepei Lei, Keya Li, Ran Zhou, Lin Bai, Chuan Qin
Summary: This study revealed gene expression changes in the five brain regions following exposure to 6-hydroxydopamine in PD rats, identifying key pathways and cascade involved in synaptic damage. The dopaminergic synapse, retrograde endocannabinoid signaling, and Gi/o-GIRK were highlighted as potential key pathways. Potential candidate genes such as Ephx2, Fam111a, and Gng2 were identified for further studies on the pathogenesis of PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Mareike Fauser, Manuel Ricken, Franz Markert, Nikolai Weis, Oliver Schmitt, Jan Gimsa, Christine Winter, Kathrin Badstuebner-Meeske, Alexander Storch
Summary: The study revealed that animals treated with STN-DBS had significantly increased numbers of dopamine neurons and fibers, potentially improving sensorimotor neglect. This therapy not only affected the nigrostriatal system, but also had a significant impact on the mesolimbic system.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Hematology
Xiaojuan Zhao, Dominic Alibhai, Ting Sun, Jawad Khalil, James L. Hutchinson, Kaya Olzak, Christopher M. Williams, Yong Li, Richard Sessions, Stephen Cross, Richard Seager, Riyaad Aungraheeta, Alan Leard, Caroline M. McKinnon, David Phillips, Lei Zhang, Alastair W. Poole, George Banting, Stuart J. Mundell
Summary: The protein tetherin/BST-2 plays a fundamental role in negatively regulating membrane microdomain-expressed platelet receptor function. Its expression reduces receptor activation and trafficking, enhancing the function of a subset of membrane microdomain-expressing receptors in platelets. This study provides insights into the physiological relevance of tetherin/BST-2 in platelet function and signaling.
Article
Environmental Sciences
Camila G. Dantas, Ailma O. da Paixao, Tassia L. G. M. Nunes, Italo J. F. Silva, Bruno dos S. Lima, Adriano A. S. Araujo, Ricardo L. C. de Albuquerque-Junior, Katia P. Gramacho, Francine F. Padilha, Luiz P. da Costa, Patricia Severino, Juliana C. Cardoso, Eliana B. Souto, Margarete Z. Gomes
Summary: This study evaluated the neuroprotective effects of Africanized bee venom (BV) on a mice model of Parkinson's disease induced by 6-hydroxydopamine (6-OHDA). The results showed that BV could counteract the symptoms caused by 6-OHDA, reduce cell death, and protect the striatum from damage. These findings suggest that Africanized bee venom may have potential as a novel therapeutic approach for Parkinson's disease.
Article
Food Science & Technology
Catherine Anna-Marie Graham, Beatrice Spedicati, Giulia Pelliccione, Paolo Gasparini, Maria Pina Concas
Summary: Genetics have a significant influence on individual differences in food liking, which in turn affects food choices and health outcomes. This study conducted a genome-wide association study to explore the genetic factors associated with sweet food liking. The results identified a strong association between the RGS9I gene and sweet food liking, with a specific SNP (rs58931966) showing a significant effect. This genetic association was also linked to behavior, such as food adventurousness and reward dependence, as well as health parameters including BMI and blood glucose levels.
Article
Biochemistry & Molecular Biology
Bira Arumndari Nurrahma, Tu-Hsueh Yeh, Rong-Hong Hsieh, Shu-Ping Tsao, Chia-Wen Chen, Yen-Peng Lee, Chun-Hsu Pan, Hui-Yu Huang
Summary: The study suggests that mangosteen pericarp extract may delay the progression of Parkinson's disease by counteracting oxidative stress and improving gut microbiota composition.
Article
Pharmacology & Pharmacy
Clarissa A. Pisano, Daniela Mercatelli, Martina Mazzocchi, Alberto Brugnoli, Ilaria Morella, Stefania Fasano, Nurulain T. Zaveri, Riccardo Brambilla, Gerard W. O'Keeffe, Richard R. Neubig, Michele Morari
Summary: The study indicates that RGS4 physiologically inhibits NOP receptor signaling and the chemical probe CCG-203920 can enhance NOP responses and improve the antidyskinetic potential of NOP receptor agonists.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li, Zengfu Liu, Jiayun Zheng, Yunxin Wang, Hanqun Liu, Lijian Wei, Yilin Su, Yuwan Lin, Wei Dai, Zhiling Zhang, Xiang Chen, Liuyan Ding, Wenyuan Guo, Xiaoqin Zhu, Pingyi Xu, Mingshu Mo
Summary: This study established a rat model of Parkinson's disease (PD) using 6-hydroxydopamine (6-OHDA) and analyzed the lipid profile in cerebrospinal fluid (CSF) using lipidomic approaches. The results showed significant effects of 6-OHDA on behavior, dopaminergic neurons, and lipid composition in CSF. Specific lipid families and species exhibited fluctuations during the progression of Parkinson's disease and were correlated with behavioral and pathological changes in the midbrain.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ana Carolina D. Noseda, Lais S. Rodrigues, Adriano D. S. Targa, Jessica L. Ilkiw, Juliane Fagotti, Patricia D. dos Santos, Erika Cecon, Regina P. Markus, Michele Solimena, Ralf Jockers, Marcelo M. S. Lima
Summary: Melatonin MT2 receptors in the glomerular layer are implicated in depressive-like behaviors and olfactory function impairment associated with Parkinson's disease, as demonstrated in a rat model using 6-OHDA-induced lesions. The activation of these receptors by melatonin and specific drugs shows potential for treating non-motor symptoms in PD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Chaoyi Qin, Yiheng Zan, Liang Xie, Hanmin Liu
Summary: ATM plays an important role in the PDGF-BB-induced proliferation of PASMCs through ROS formation. Inhibition of ATM promotes the proliferation of PASMCs under excessive levels of PDGF-BB and H2O2.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Christine Fok, Milan Bogosanovic, Madhavi Pandya, Ravindra Telang, Peter R. Thorne, Srdjan M. Vlajkovic
Summary: This study aimed to investigate the otoprotective effect of increasing A(1)R responsiveness to endogenous adenosine by targeting RGS4, which was achieved through pharmacological intervention. The results showed that intratympanic administration of a RGS4 inhibitor could attenuate noise-induced auditory threshold shifts and improve survival of sensorineural tissues in the cochlea, suggesting a novel approach for the treatment of SNHL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Saeideh Nourmohammadi, Sanaz Yousefi, Mahboubeh Manouchehrabadi, Mona Farhadi, Zahra Azizi, Anahita Torkaman-Boutorabi
Summary: In this study, the potential neuroprotective effects of thymol were investigated in in vitro and in vivo models of Parkinson's disease. The results suggest that thymol exerts protective effects, possibly through its antioxidant properties.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Multidisciplinary Sciences
Michaela Roth, Chantal Roubinet, Niklas Ifflaender, Alexia Ferrand, Clemens Cabernard
NATURE COMMUNICATIONS
(2015)
Article
Neurosciences
Thomas Padel, Michaela Roth, Abderahim Gaceb, Jia-Yi Li, Maria Bjorkqvist, Gesine Paul
EXPERIMENTAL NEUROLOGY
(2018)
Article
Multidisciplinary Sciences
Robert Carlsson, Ilknur Ozen, Marco Barbariga, Abderahim Gaceb, Michaele Roth, Gesine Paul
Article
Clinical Neurology
Ilknur Ozen, Michaela Roth, Marco Barbariga, Abderahim Gaceb, Tomas Deierborg, Guillem Genove, Gesine Paul
Article
Biochemistry & Molecular Biology
Michaela Roth, Abderahim Gaceb, Andreas Enstrom, Thomas Padel, Guillem Genove, Ilknur Ozen, Gesine Paul
Article
Neurosciences
Michaela Roth, Andreas Enstrom, Candice Aghabeick, Robert Carlsson, Guillem Genove, Gesine Paul
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)