期刊
NEUROBIOLOGY OF AGING
卷 38, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2015.10.028
关键词
Dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; Genetic correlation
资金
- Alzheimer's Society
- Parkinson's UK Innovation Award [K-1204]
- Lewy Body Society
- Wellcome Trust/MRC Joint Call in Neurodegeneration award [WT089698]
- University of Sheffield
- MRC Protein Phosphorylation Unit at the University of Dundee
- Spanish Ministry of Science and Innovation [SAF2006-10126, SAF2010-22329-C02-01, SAF2013-47939-R]
- UTE project FIMA
- Medical Research Council (MRC)
- Brains for Dementia Research (BDR) (Alzheimer Society and Alzheimer Research UK)
- Autistica UK
- NIHR Oxford Biomedical Research Centre
- Stichting Dioraphte fond
- Stichting VUMC fond
- Neuroscience Research Australia
- University of New South Wales
- National Health and Medical Research Council of Australia
- Wellcome Trust
- Medical Research Council
- Canadian Institutes of Health Research
- Ontario Research Fund
- ARUK
- Big Lottery Fund
- Taub Institute
- Panasci Fund
- Parkinson's Disease Foundation
- NIH [NS060113, P50AG008702, P50NS038370, UL1TR000040]
- Michael J. Fox Foundation, NINDS [NS078086]
- Mangurian Foundation for Lewy body research
- Queen Square Brain Bank at the UCL Institute of Neurology
- NIHR UCLH Biomedical Research Centre
- Queen Square Dementia Biomedical Research Unit
- National Institute for Health Research (NIHR) Dementia Biomedical Research Unit
- Biomedical Research Centre at South London
- Maudsley NHS Foundation Trust
- King's College Hospital, London
- National Institute on Aging, National Institutes of Health, Department of Health and Human Services [AG000951-12]
- Alzheimer's Society [200] Funding Source: researchfish
- Medical Research Council [MR/L010305/1, G9318379, MR/L022656/1, MR/L023784/2, G1100695, MR/L016397/1] Funding Source: researchfish
- Parkinson's UK [K-1204, G-0909] Funding Source: researchfish
- MRC [MC_G1000734, MR/L016397/1, MR/N012453/1, G9318379, MR/L022656/1, MR/L023784/2, G1100695] Funding Source: UKRI
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. (C) 2016 The Authors. Published by Elsevier Inc.
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