期刊
NEUROBIOLOGY OF AGING
卷 40, 期 -, 页码 86-97出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.01.006
关键词
Brain aging; Gray matter; Hippocampus; Oldest old; Structural MRI; White matter hyperintensities
资金
- National Health and Medical Research Council (NHMRC) of Australia [630593, 350833, 568969]
Successful brain aging in the oldest old (>= 90 years) is underexplored. This study examined cross-sectional brain morphological differences from 8th to 11th decades of life in nondemented individuals by high-resolution magnetic resonance imaging. Two hundred seventy-seven nondemented community-dwelling participants (71-103 years) from Sydney Memory and Ageing Study and Sydney Centenarian Study comprised the sample, including a subsample of 160 cognitively high-functioning elders. Relationships between age and magnetic resonance imaging-derived measurements were studied using general linear models; and structural profiles of the >= 90 years were delineated. In full sample and the subsample, significant linear negative relationship of gray matter with age was found, with the greatest age effects in the medial temporal lobe and parietal and occipital cortices. This pattern was further confirmed by comparing directly the >= 90 years to the 71-89 years groups. Significant quadratic age effects on total white matter and white matter hyperintensities were observed. Our study demonstrated heterogeneous differences across brain regions between the oldest old and young old, with an emphasis on hippocampus, temporoposterior cortex, and white matter hyperintensities. (C) 2016 Elsevier Inc. All rights reserved.
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