期刊
NEUROBIOLOGY OF AGING
卷 38, 期 -, 页码 118-126出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2015.11.012
关键词
Aging; APOE; Dedifferentiation; Memory; Olfaction
资金
- Swedish Ministry of Health and Social Affairs
- Swedish Research Council
- Swedish Foundation for Humanities and Social Sciences [M14-0375:1]
- Swedish Council for Working Life and Social Research
- Swedish Brain Power
- Alexander von Humboldt Research Award
- af Jochnick Foundation
- participating County Councils and Municipalities
- Swedish Foundation for Humanities and Social Sciences [M14-0375:1] Funding Source: Swedish Foundation for Humanities and Social Sciences
The neuroanatomical organization that underlies olfactory memory is different from that of other memory types. The present work examines olfactory memory in an elderly population-based sample (Swedish National Study on Aging and Care in Kungsholmen) aged 60-100 years (n = 2280). We used structural equation modeling to investigate whether olfactory memory in old age is best conceptualized as a distinct category, differentiated from episodic and semantic memory. Further, potential olfactory dedifferentiation and genetic associations (APOE) to olfactory function in late senescence were investigated. Results are in support of a 3-factor solution where olfactory memory, as indexed by episodic odor recognition and odor identification, is modeled separately from episodic and semantic memory for visual and verbal information. Increasing age was associated with poorer olfactory memory performance, and observed age-related deficits were further exacerbated for carriers of the APOE epsilon 4 allele; these effects tended to be larger for olfactory memory compared to episodic and semantic memory pertaining to other sensory systems (vision, auditory). Finally, stronger correlations between olfactory and episodic memory, indicating dedifferentiation, were observed in the older age groups. (C) 2016 Elsevier Inc. All rights reserved.
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