Review
Chemistry, Organic
Sabrina Giofre, Letizia Molteni, Egle M. Beccalli
Summary: This Review presents the progress in catalytic enantioselective mono- and difunctionalization of alkenes, with a focus on the fundamental role of ligands. Various types of asymmetric reactions involving different bond formation, such as C-O, C-N, and C-C bonds, have been developed. The urgency to discover new ligands and synthetic methodologies is emphasized to enhance control over reaction selectivity and activity, and to expand the applications in the synthesis of heterocyclic scaffolds and biologically active compounds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Hongbin Zhai, Dong Liu, Taimin Wang
Summary: A nine-step asymmetric total synthesis of (+)-tubingensin A has been achieved, featuring intramolecular Heck reaction for establishing the key vicinal quaternary stereocenter motif present in the natural product and late-stage Zweifel olefination for side chain elongation.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Majid Mohammadnia, Nazanin Poormirzaei
Summary: A new magnetic nanocatalyst, Pd supported on 5-carboxyoxindole functionalized cell@Fe3O4 nanoparticles, was synthesized and successfully employed for the Heck-type arylation of different substituted maleimides. This green catalyst can be easily recovered and reused multiple times without significant loss of activity, providing a clean and efficient synthetic procedure.
NANOSCALE ADVANCES
(2021)
Article
Chemistry, Multidisciplinary
Maxwell B. Haughey, Kirsten E. Christensen, Darren L. Poole, Timothy J. Donohoe
Summary: The successful synthesis of the complex taiwanschirin fused [8,6,5] core, representing challenging and biologically active targets, was achieved through a novel alkynylation reaction and intramolecular Heck reaction method.
Article
Materials Science, Paper & Wood
Melike Caliskan, Talat Baran
Summary: A novel nanocatalyst system (Pd@CS-ZnO) was developed by attaching palladium nanoparticles onto a hybrid nanocomposite of chitosan and ZnO nanoparticles. The catalytic efficiency of Pd@CS-ZnO was assessed for Heck coupling reaction, showing promising results. The Pd@CS-ZnO nanocatalyst demonstrated easy separation and high chemical stability, making it a cost-effective and eco-friendly catalyst system.
Article
Chemistry, Organic
Yi-Fan Wang, Yu-Han He, Yan Su, Yang Ji, Rui Li
Summary: In this study, a palladium complex coordinated with a chiral SIPHOS ligand was evaluated as an efficient catalyst for asymmetric hydrosilylation reaction. The results showed that good to excellent enantioselectivities could be obtained in the hydrosilylation reaction of 1-aryl-2-silyl ethanols with selectively converted trichlorosilyl groups. Additionally, stable and high-yielding 1,2-bis(silyl) chiral compounds could be produced through the asymmetric hydrosilylation of beta-silyl styrenes followed by methylation of the trichlorosilyl group.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ziyan Zhang, Nikita Kvasovs, Anastasiia Dubrovina, Vladimir Gevorgyan
Summary: This method utilizes visible light-induced and Bronsted acid-assisted generation of hybrid palladium C(sp(3))-centered radical intermediate, enabling efficient transformation of a wide range of vinyl arenes, heteroarenes, and diazo compounds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Xiaopeng Peng, Yang Yang, Bingling Luo, Shijun Wen, Peng Huang
Summary: A diverse set of fluorenes can be conveniently constructed starting from cyclic diaryliodoniums and terminal alkenes through Pd-catalyzed reactions. These reactions involve a conventional Mizoroki-Heck reaction and a reductive Heck reaction, with a general scope of alkenes leading to the synthesis of 29 fluorenes, expanding the structural diversity of fluorenes.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Pierre Hansjacob, Frederic R. Leroux, Vincent Gandon, Morgan Donnard
Summary: The palladium-catalyzed silylcyanation of ynamides is highly selective, producing exclusively tetrasubstituted 2-aminoacrylonitriles derivatives. The stereoselectivity is directly controlled by the nature of the substituent at the beta-position of the ynamide. The reaction is tolerant of various functional groups and provides a general method to access fully substituted 2-aminoacrylonitriles. The mechanism of this intriguing transformation is elucidated by computational study, and the range of 2-aminoacrylonitriles is expanded through postfunctionalization using the newly installed vinylsilane functionality.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Nikita Kvasovs, Jian Fang, Fedor Kliuev, Vladimir Gevorgyan
Summary: A visible light-induced palladium-catalyzed synthesis of allylic amines was developed. This method involves a hybrid radical alkyl Heck reaction and a classical Tsuji-Trost-type allylic substitution reaction, enabled by the same Pd(0) catalyst through two distinct cycles. It shows good compatibility with various primary and secondary amines, aryl alkenes, dielectrophiles, and complex settings, and the regiochemistry of the products is controlled by the structure of 1,1-dielectrophile. The stereoselectivity can be controlled by the involvement of π-allylpalladium intermediates, achieving up to 95:5 er.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Ze-Jian Xue, Meng-Yao Li, Bin-Bin Zhu, Zhi-Tao He, Chen-Guo Feng, Guo-Qiang Lin
Summary: The palladium-catalyzed cross-coupling of ortho-vinyl aromatic bromides and olefins using a controllable 1,4-palladium migration/Heck cascade protocol is a mild, efficient, and highly stereoselective method for the synthesis of trisubstituted 1,3-dienes, especially triaryl-substituted ones.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Chemistry, Multidisciplinary
Jia-Qi Xie, Ren-Xiao Liang, Yi-Xia Jia
Summary: This review focuses on recent development of catalytic asymmetric Heck reaction and reductive Heck reaction, covering intermolecular and intramolecular versions since 2011. The article is organized in terms of the catalysts and olefin substrates, providing a clear structure for readers.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Paz Yepes, Angel L. Suarez-Sobrino, Miguel A. Rodriguez, Alfredo Ballesteros
Summary: The regio- and stereoselective carbosilylation reaction of tosylynamides with allylic trimethylsilanes is efficiently catalyzed by TMSNTf2 or HNTf2, resulting in high yields of (Z)-α-allyl-P-trimethylsilylenamides. Theoretical calculations reveal that the C-C triple bond of the ynamides is activated by the trimethylsilylium ion, leading to the formation of a P-trimethylsilylketenimonium cation. The subsequent transformations of the products demonstrate the synthetic utility of this reaction.
Article
Chemistry, Organic
Qinhui Wan, Zhong-Wei Hou, Xin-Ru Zhao, Xiaoyu Xie, Lei Wang
Summary: An organoelectrophotocatalytic approach has been developed for the C-H silylation of heteroarenes through dehydrogenation cross-coupling with H2 evolution. The strategy uses 9,10-phenanthrenequinone as both an organocatalyst and a hydrogen atom transfer reagent, eliminating the need for external reagents. This approach shows excellent regioselectivity and can be applied to various heteroarenes with satisfactory yields.
Article
Chemistry, Applied
Gang Wang, Mingzhu Wei, Tianxiang Liu, Weiwei Jin, Yonghong Zhang, Bin Wang, Yu Xia, Chenjiang Liu
Summary: A palladium-catalyzed stereoselective intramolecular Heck dearomative of indoles with silyl termination has been developed. This method allows the synthesis of tetracyclic indoline derivatives containing silicon, using N-(2-bromobenzoyl)indoles and silylboronates as starting materials. The protocol shows a broad substrate scope and high yields, and can be scaled up as well as further transformed.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Review
Chemistry, Organic
Bojan Vulovic, Donald A. Watson
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Feiyang Xu, Scott A. Shuler, Donald A. Watson
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Chemistry, Multidisciplinary
Vijayarajan Devannah, Rajgopal Sharma, Donald A. Watson
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Review
Chemistry, Multidisciplinary
Katerina M. Korch, Donald A. Watson
Article
Chemistry, Inorganic & Nuclear
William Reid, Jesse R. McAtee, Donald A. Watson
Article
Chemistry, Multidisciplinary
Michael F. Wisthoff, Sarah B. Pawley, Andrew P. Cinderella, Donald A. Watson
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Feiyang Xu, Olivia M. Duke, Daniel Rojas, Hanka M. Eichelberger, Raphael S. Kim, Timothy B. Clark, Donald A. Watson
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Organic
Raphael S. Kim, Linh Dinh-Nguyen, Kirk W. Shimkin, Donald A. Watson
Article
Chemistry, Multidisciplinary
Ziqing Zuo, Raphael S. Kim, Donald A. Watson
Summary: An asymmetric homocoupling reaction produces highly enantioenriched axially chiral bisphosphine compounds, allowing for the practical development of previously uninvestigated chiral bisphosphine ligands. The conditions are also effective for asymmetric dimerization of non-phosphorus-containing aryl halides.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Katerina M. Korch, Donald A. Watson
Summary: The synthesis of the natural product impatien A was achieved using an aza-Heck cyclization to construct the complex spirocyclic ring system, showcasing an efficient synthetic method. Through high-throughput experimentation, a new ligand was identified to enable the key cyclization reaction, ultimately allowing impatien A to be synthesized in seven steps from known compounds.
Article
Chemistry, Organic
Olamide O. Idowu, Jacob C. Hayes, William B. Reid, Donald A. Watson
Summary: The research reported a method for synthesizing 1,1-diboryl alkenes from terminal alkenes, showing 1,1-regioselective addition for both conjugated and unconjugated alkenes. This provides a single method to prepare a wide range of 1,1-diboryl alkenes.
Article
Chemistry, Physical
Katerina M. Korch, Jacob C. Hayes, Raphael S. Kim, Jessica Sampson, Austin T. Kelly, Donald A. Watson
Summary: High-throughput experimentation workflows are efficient for surveying chiral catalysts in catalytic asymmetric reactions. Traditional HPLC methods for determining ee can be hindered by coelution of other components, but LC-MS, SFC-MS, and SIM mass chromatography provide accurate ee determination for crude samples. This method is effective even for samples without UV/vis chromophores, making it ideal for HTE workflows in asymmetric catalysis.
Article
Chemistry, Physical
Sarah B. Pawley, Allyssa M. Conner, Humair M. Omer, Donald A. Watson
Summary: General conditions for the Hiyama-Denmark cross coupling of tetrasubstituted vinyl silanes and aryl halides are reported, enabling the coupling of unactivated vinyl silanes and displaying high stereospecificity. This important discovery simplifies the reaction procedure and reduces the use of toxic additives.
Article
Chemistry, Multidisciplinary
Sina Rezazadeh, Maxwell I. Martin, Raphael S. Kim, Glenn P. A. Yap, Joel Rosenthal, Donald A. Watson
Summary: The paper reports the nickel-catalyzed alkylation of secondary nitroalkanes using aliphatic iodides to obtain tertiary nitroalkanes. Previously, this method was not feasible due to steric hindrance, but the use of a nickel catalyst in combination with a photoredox catalyst and light overcomes this limitation. The conditions are scalable and tolerant to air and moisture. Importantly, reduction of the resulting tertiary nitroalkanes allows rapid access to alpha-tertiary amines.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Run-Duo Gao, Scott A. Shuler, Donald A. Watson
Summary: The study presents a novel palladium-catalyzed tandem reaction for the synthesis of complex, stereogenic secondary lactams from O-phenyl hydroxamic ethers. The reactions exhibit outstanding functional group tolerance and high diastereoselectivity.