期刊
CHEMICAL RECORD
卷 16, 期 1, 页码 249-260出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201500249
关键词
cyclodextrins; fullerenes; host-guest systems; liposomes; photodynamic therapy
资金
- JSPS KAKENHI [25288037, 24655128]
- Grants-in-Aid for Scientific Research [25288037, 24655128] Funding Source: KAKEN
An effective exchange method is described whereby liposomal drug carriers of hydrophobic guest biomolecules are used to incorporate the guests into lipid membranes. The exchange method transfers the guest molecule from a cyclodextrin cavity to a liposome in water. Lipid-membrane-incorporated fullerenes (LMICx: x=60 or 70) prepared by the exchange method have much higher liposomal stability and fullerene water solubility than those prepared by conventional methods. The LMIC60 have high photodynamic activities with respect to human cancer cells under 350-500 nm excitation. Furthermore, the LMIC60 bilayers, containing light-harvesting antenna molecules in addition to the C-60, showed improved activities at the optimal wavelength for photodynamic therapy.
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