Article
Clinical Neurology
Esther Cubo, Joan Miravite, Sara Calvo, Kathryn Cooper, Deborah Raymond, Hwai Yin Ooi, Naomi Lubarr, Susan Bressman, Rachel Saunders-Pullman
Summary: The study evaluated MCID thresholds for BFMDRS in patients with genetically determined dystonia undergoing DBS. Patients with improvement showed a median reduction of 77% in BFMDRS-MS score, while those without improvement had a reduction of 62%. Larger studies comparing MCID in different populations are needed.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Juan Diego Vintimilla-Sarmiento, Jose Damian Carrillo-Ruiz, Jose Luis Navarro-Olvera, Gustavo Aguado-Carrillo, Julian Eduardo Soto-Abhraham, Francisco Jesus Velasco-Campos
Summary: The study evaluated the effectiveness of RF pallidotomy in treating refractory dystonia, showing significant improvements in movement and disability scores after the procedure. This suggests that RF pallidotomy is a viable treatment option for patients with dystonia who meet specific selection criteria.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Review
Behavioral Sciences
Alex Medina Escobar, Tamara Pringsheim, Zahra Goodarzi, Davide Martino
Summary: Adult onset idiopathic dystonia (AOID) patients have a high prevalence of supra-clinical threshold depressive symptoms/depressive disorders, with specific numbers varying among different types of dystonia. The prevalence of supra-clinical threshold depressive symptoms screened by rating scales is higher than that of depressive disorders diagnosed with structured interviews. Further research is needed to standardize screening methodology and characterization of mood disorders in AOID.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Neurosciences
Alana B. McCambridge, Lynley V. Bradnam
Summary: This study provides a synthesized understanding of cortical neurophysiology associated with isolated dystonia through meta-analysis of TMS measures. The results indicate a reduction in cortical silent period, short-interval intracortical inhibition, and afferent-induced inhibition in isolated dystonia compared to controls, suggesting potential new treatment targets for this poorly understood movement disorder.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Gamze Kilic-Berkmen, Laura J. Wright, Joel S. Perlmutter, Cynthia Comella, Mark Hallett, Jan Teller, Sarah Pirio Richardson, David A. Peterson, Carlos Cruchaga, Codrin Lungu, H. A. Jinnah
Summary: Dystonia is a rare movement disorder with heterogeneous subtypes and causes, posing challenges for research. The Dystonia Coalition, established in 2009, fosters international collaboration to advance research in defining, classifying, diagnosing, evaluating, and conducting multi-center studies on dystonia.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Edoardo Ferlazzo, Michele Ascoli, Francesca Abate, Sara Gasparini, Giovanni Mastroianni, Vittoria Cianci, Giulia Ferrigno, Chiara Sueri, Tiziana D'Agostino, Umberto Aguglia
Summary: Dystonia is a common and previously underestimated clinical feature in adults and adolescents with AS, with 93.3% of subjects showing dystonia, mainly affecting the upper limbs. The severity of dystonia ranges from slight to moderate, with a linear correlation between severity and age.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Haochen Guan, Zhi Geng, Weijie Yuan, Bowen Chang
Summary: The study found that low uric acid levels could be a risk factor for the development of Meige's syndrome, and it is also associated with the severity of the disease.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Food Science & Technology
Wolfgang H. Jost
Summary: Botulinum neurotoxin (BoNT) has been used for a wide range of indications in patients with Parkinson's syndrome, with approved indications including sialorrhea, cervical dystonia, and blepharospasm, while other indications like tremor and hyperhidrosis still lack sufficient data support.
Article
Clinical Neurology
Inti Vanmechelen, Annika Danielsson, Cecilia Lidbeck, Kristina Tedroff, Elegast Monbaliu, Lena Krumlinde-Sundholm
Summary: The aim of this study was to develop a shortened and more user-friendly second edition of the Dyskinesia Impairment Scale (DIS-II) to assess dystonia and choreoathetosis, and evaluate its construct validity and reliability. The DIS-II showed good construct validity and reliability in evaluating dystonia and choreoathetosis in individuals with dyskinetic cerebral palsy or inherited/idiopathic dystonia.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Food Science & Technology
Kazuya Yoshida
Summary: This study used a comprehensive measurement tool called OMDRS to evaluate the health-related quality of life in patients with oromandibular dystonia. The study found that botulinum neurotoxin therapy significantly improved the HRQoL of patients with oromandibular dystonia.
Article
Clinical Neurology
Adam C. Cotton, Laura Scorr, William McDonald, Cynthia Comella, Joel S. Perlmutter, Christopher G. Goetz, Joseph Jankovic, Laura Marsh, Stewart Factor, H. A. Jinnah
Summary: By accounting for non-motor features, the correlation between clinician-rated scales and patient-rated outcome tools for assessing disease severity in cervical dystonia can be improved.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Giovanni Defazio, Mark Hallett, Alfredo Berardelli, Joel S. Perlmutter, Brian D. Berman, Joseph Jankovic, Tobias Baeumer, Cynthia Comella, Tommaso Ercoli, Gina Ferrazzano, Susan H. Fox, Han-Joon Kim, Emile Sami Moukheiber, Sarah Pirio Richardson, Anne Weissbach, Angelo F. Gigante, Hyder A. Jinnah
Summary: This study compared the measurement properties of four clinical scales in assessing the severity of Blepharospasm (BSP) in a large sample of patients from multiple sites. The Global Dystonia Severity Rating Scale (GDRS) was found to be suitable for assessing both BSP and dystonia in other body parts, while the Jankovic Rating Scale (JRS) and Blepharospasm Severity Rating Scale (BSRS) were suitable for assessing BSP alone.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Klara Gacina, Mladen Lesin, Dean Sarajcev, Nina Rotim
Summary: This study aimed to investigate the effect of botulinum toxin type A on patients with essential blepharospasm and their satisfaction. The results showed that the use of botulinum toxin significantly improved the quality of life and reduced the severity and frequency of symptoms.
ACTA CLINICA CROATICA
(2022)
Article
Clinical Neurology
Tobias Mantel, Andre Lee, Shinichi Furuya, Masanori Morise, Eckart Altenmueller, Bernhard Haslinger
Summary: The study validates an ED severity rating scale (EDSRS) for standardized assessment of ED severity. The EDSRS showed high internal consistency, interrater reliability, intrarater reliability over time, and good precision. It also correlated significantly with F0 variability, indicating its validity as a tool for assessing ED severity.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Marina Ramella, Rosa Maria Converti, Giulia Giacobbi, Anna Castagna, Enrico Saibene, Francesca Borgnis, Francesca Baglio
Summary: The study found that symptoms of dystonia typically appeared around the age of 33 and lasted for at least three years. The TAPS demonstrated good internal consistency and is a reliable and valid tool for assessing the burden of MFD in clinical settings.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Geriatrics & Gerontology
Chizoba C. Umeh, Abhimanyu Mahajan, Aleksandra Mihailovic, Gregory M. Pontone
Summary: The presence of the APOE4 allele in Parkinson's disease patients is associated with a higher risk of subsequent dementia diagnosis and faster progression to dementia, but this relationship is not modified by sex. Those with the APOE4 allele are more likely to have neuropathology associated with Alzheimer's disease.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2022)
Review
Clinical Neurology
Luca Marsili, Abhimanyu Mahajan
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Gamze Kilic-Berkmen, Sarah Pirio Richardson, Joel S. Perlmutter, Mark Hallett, Christine Klein, Aparna Wagle-Shukla, Irene A. Malaty, Stephen G. Reich, Brian D. Berman, Jeanne Feuerstein, Marie Vidailhet, Emmanuel Roze, Joseph Jankovic, Abhimanyu Mahajan, Alberto J. Espay, Richard L. Barbano, Mark S. LeDoux, Alexander Pantelyat, Samuel Frank, Natividad Stover, Alfredo Berardelli, Julie Leegwater-Kim, Giovanni Defazio, Scott A. Norris, Hyder A. Jinnah
Summary: The study aimed to determine clinical features used by movement disorder specialists in the diagnosis and classification of isolated focal cervical dystonia, and to develop recommendations for a more consistent approach to classification. Results showed that even though diagnosed with isolated focal cervical dystonia, a high percentage of subjects exhibited dystonia outside of the neck region, indicating the need for more specific guidelines for defining this common disorder.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Clinical Neurology
Zachary N. London, Abhimanyu Mahajan, Carolyn Cahill, Jaffar Khan, Erica A. Schuyler, Raymond S. Price
Summary: The fellowship application process for neurology subspecialties should begin in the first half of the second year of neurology-specific training. The American Academy of Neurology (AAN) recommends that communication between fellowship candidates and training programs should start no earlier than March 1 of the penultimate year of training, with fellowship positions being offered no earlier than August 1 of the final year of training. Survey results indicate that most residents who recently completed the fellowship application process agree with the suggested timeline and suggest the adoption of a fellowship match for all neurology subspecialties.
Article
Clinical Neurology
W. R. Wayne Martin, John R. Younce, Meghan C. Campbell, Brad A. Racette, Scott A. Norris, Mwiza Ushe, Susan Criswell, Albert A. Davis, Isabel Alfradique-Dunham, Baijayanta Maiti, Nigel J. Cairns, Richard J. Perrin, Paul T. Kotzbauer, Joel S. Perlmutter
Summary: This study investigates the relationship between Parkinson's disease (PD) with dementia and cortical proteinopathies. The study finds that neocortical Lewy bodies are commonly present in PD patients with dementia, but also appear in those without dementia. Other factors may contribute to PD dementia, aside from the classic neuropathological features.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Roshni Abee Patel, Lucia Blasucci, Abhimanyu Mahajan
Summary: This study investigated the effects of a 12-week community-based boxing exercise program on motor and non-motor symptoms in Parkinson's disease patients. The results showed significant improvements in motor exam and non-motor symptoms for the participants.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Diksha Mohanty, Ankita Gupta, David Sheyn, Jeremy T. Gaskins, Md Yasin Ali Parh, C. Emi Bretschneider, Abhimanyu Mahajan
Summary: The objective of this study was to assess the effect of Parkinson's disease on perioperative outcomes following gynecologic surgery. The study found that Parkinson's disease does not worsen perioperative outcomes, and neurologists can use this information to provide reassurance to women with Parkinson's disease undergoing such procedures.
PARKINSONISM & RELATED DISORDERS
(2023)
Editorial Material
Clinical Neurology
Abhimanyu Mahajan, Ludy C. Shih
SEMINARS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Luca Marsili, Matteo Bologna, Abhimanyu Mahajan
Summary: The diagnosis and approach to patients with tremor can be challenging for clinicians. It is crucial to differentiate between different types of tremors and carefully examine other relevant features. A correct approach is important for appropriate referral, counseling, prognosis definition, and therapeutic management of patients. This review outlines the diagnostic uncertainties and highlights the role of neurophysiology, neuroimaging, and genetics in the diagnostic process.
SEMINARS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Alfonso E. Martinez-Nunez, Hamid Soltanian-Zadeh, Katie Latack, Nayereh Ghazi, Abhimanyu Mahajan
Summary: This study analyzed data from 40 patients with early-stage Parkinson's disease and found that there is a significant overlap between the neuroanatomical structures involved in olfactory dysfunction and apathy. The study also found that structural connectivity changes associated with apathy can be observed in early-stage PD patients with smell dysfunction.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Dana Sugar, Roshni Patel, Cynthia Comella, David A. Gonzalez, Gabrielle Gray, Glenn T. Stebbins, Abhimanyu Mahajan
Summary: This study evaluated the impact of botulinum toxin on anxiety symptoms in patients with cervical dystonia. The results showed that botulinum toxin not only improved the severity of motor symptoms, but also reduced anxiety symptoms.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Abhimanyu Mahajan, David A. Gonzalez, Glenn T. Stebbins, Cynthia Comella
Summary: This study found that sensory tricks can reduce the severity of cervical dystonia and the dosage of treatment medication. Complete sensory tricks were associated with lower treatment dosage, while the absence of complete sensory tricks was associated with higher treatment dosage.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Neurosciences
Jack Shen, Luca Marsili, Alok K. Dwivedi, Gregory Kuhlman, Andrew P. Duker, Alberto J. Espay, Abhimanyu Mahajan
Summary: This study found no correlation between head tremor and postural instability in patients with essential tremor who underwent bilateral ventral intermediate nucleus deep brain stimulation.