Review
Geriatrics & Gerontology
Firoz Akhter, Alicia Persaud, Younis Zaokari, Zhen Zhao, Donghui Zhu
Summary: Vascular dementia (VaD) is a type of dementia caused by reduced blood flow to the brain, accounting for 20% of all dementia cases. There are subtle differences in the presentation of VaD between males and females, but they are often overlooked.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar de Rojasj, Thiago Peixoto Leal, Akinori Miyashita, Celine Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Kucukali, Seth D. Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, Maria J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stephanie Debette, Jean-Francois Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo Garcia-Ribas, Jose Maria Garcia-Alberca, Pablo Garcia-Gonzalez, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonca, Merce Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Borge G. Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A. L. Pijnenburg, Gerard Pinol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puertaj Jordi Perez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M. Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A. Ross, Jose Luis Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Raquel Sanchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhangc, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sanchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Todau, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje van der Fliere, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D. Greicius, Emmanuel Mignot
Summary: We analyzed the HLA associations in individuals with Parkinson's disease and Alzheimer's disease across different ancestry groups and found that these two diseases share a common protective association at the HLA locus. Fine-mapping showed that specific subtypes of HLA-DRB1*04 were responsible for this association, with HLA-DRB1*04:04 and HLA-DRB1*04:07 showing the strongest association. This protective effect was also associated with decreased neurofibrillary tangles in the brain and reduced levels of tau protein in cerebrospinal fluid.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Benjamin B. Tournier, Silvia Sorce, Antoine Marteyn, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Francois R. Herrmann, Karl-Heinz Krause, Dina Zekry
Summary: This study investigates the links between CCR5 deficiency, neuronal sensitivity to oxidative stress, and the development of dementia. The results show that CCR5-& UDelta;32 allele, when combined with ApoE & epsilon;4, increases the risk for dementia, particularly vascular dementia. Additionally, Ccr5 deficiency in mice neurons leads to increased vulnerability to oxidative stress-induced cell death, suggesting a possible mechanism contributing to dementia.
ALZHEIMERS & DEMENTIA
(2023)
Review
Geriatrics & Gerontology
Xuanlin Li, Lin Huang, Yujun Tang, Xuanming Hu, Chengping Wen
Summary: The aim of this meta-analysis was to evaluate the risk of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VD) in gout patients. The results showed that gout patients had a lower risk of all-cause dementia, AD, and VD, but the quality of evidence was generally low, and more studies are needed to validate and explore the mechanisms of this association.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Min Young Chun, Hyemin Jang, Soo-Jong Kim, Yu Hyun Park, Jihwan Yun, Samuel N. Lockhart, Michael Weiner, Charles De Carli, Seung Hwan Moon, Jae Yong Choi, Kyung Rok Nam, Byung-Hyun Byun, Sang-Moo Lim, Jun Pyo Kim, Yeong Sim Choe, Young Ju Kim, Duk L. Na, Hee Jin Kim, Sang Won Seo
Summary: Alzheimer's disease (AD) is characterized by amyloid-beta accumulation, tau aggregation, and neurodegeneration. Vascular burden has synergistic effects on cognitive decline with AD biomarkers. The distribution and longitudinal outcomes of AT(N) categories differ according to vascular burden, emphasizing the importance of incorporating a vascular biomarker into the AT(N) system.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Behavioral Sciences
Aishwarya Umesh Pradhan, Olivier Uwishema, Helen Onyeaka, Irem Adanur, Burhan Dost
Summary: Stem cell therapy has the potential to positively modify degenerative changes in dementia, but ethical concerns and the risk of uncontrolled cell differentiation leading to cancer development must be addressed. However, if appropriately developed, stem cell therapy could offer a viable treatment option for patients with dementia. Further research and clinical trials are needed to establish its efficacy in this context.
BRAIN AND BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
So Yeong Cheon, Juhyun Song
Summary: Non-alcoholic fatty liver disease (NAFLD) and dementia share common pathological characteristics, and further research is needed to understand their association and find appropriate treatment options.
CELL AND BIOSCIENCE
(2022)
Article
Geriatrics & Gerontology
Wenxiu Wang, Yongchun Luo, Zhenhuang Zhuang, Zimin Song, Ninghao Huang, Yueying Li, Xue Dong, Wendi Xiao, Yimin Zhao, Tao Huang
Summary: The study found an L-shaped association between total and regional fat-to-muscle mass ratio and dementia risk among participants aged 60 and older, independent of overall obesity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Clinical Neurology
Dae Jong Oh, Jong Bin M. Bae, Darren Lipnicki, Ji Won S. Han, Perminder Sachdev, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ingmar Skoog, Jenna R. Najar, Therese Sterner, Antonio Guaita, Roberta Vaccaro, Elena Rolandi, Nikolaos Scarmeas, Mary H. Yannakoulia, Mary G. Kosmidis, Steffi Riedel-Heller, Susanne Roehr, Jacqueline Dominguez, Ma Fe De Guzman, Krizelle Cleo Fowler, Antonio Lobo, Pedro Saz, Raul J. Lopez-Anton, Kaarin Anstey, Nicolas E. Cherbuin, Moyra Mortby, Henry Brodaty, Julian Trollor, Nicole Kochan, Ki Woong Kim
Summary: This study aims to investigate the association between parental history of dementia and the risk of dementia in offspring, and found that maternal history of dementia is associated with increased risk of dementia and Alzheimer's disease (AD), while paternal history of dementia is not. These findings may have important implications for identifying high-risk individuals for AD and stratifying the risk in clinical trials.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
R. S. Nancy Noella, J. Priyadarshini
Summary: Dementia is a brain-related issue that affects memory, and it severely impacts thinking and daily routines. Previous studies focused on diagnosing a single type of dementia, but this research proposes a system that can diagnose multiple types using FDG-PET brain scans. The system employs a generative adversarial deep convolutional neural network to generate virtual samples and address the issue of uneven distribution in the dataset. The model achieves an overall accuracy of 97.7%.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Environmental Sciences
Jung-Im Shim, Garam Byun, Jong-Tae T. Lee
Summary: This study investigated the association between long-term exposure to PM10 and the risk of developing Alzheimer's disease and vascular dementia in the elderly population. The results showed a significant link between long-term PM10 exposure and the risk of developing vascular dementia, but not Alzheimer's disease.
ENVIRONMENTAL HEALTH
(2023)
Review
Neurosciences
Sally Day, Stefanie Roberts, Nathalie H. Launder, Anita M. Y. Goh, Brian Draper, Alex Bahar-Fuchs, Samantha M. Loi, Kate Laver, Adrienne Withall, Monica Cations
Summary: Younger people with Alzheimer's disease (AD) have a worse prognosis in terms of faster cognitive decline compared to older individuals. More research is needed to determine the impact of symptom onset age in vascular dementia (VaD) and frontotemporal dementia (FTD), as well as functional decline in all types of dementias.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Xuewen Xiao, Lina Guo, Xinxin Liao, Yafang Zhou, Weiwei Zhang, Lu Zhou, Xin Wang, Xixi Liu, Hui Liu, Tianyan Xu, Yuan Zhu, Qijie Yang, Xiaoli Hao, Yingzi Liu, Junling Wang, Jinchen Li, Bin Jiao, Lu Shen
Summary: Common variants in COL4A1 and rare variants in HTRA1, NOTCH3, COL4A1, and CST3 may be implicated in AD pathogenesis in the Chinese population. Additionally, GSN, ITM2B, and COL4A1 are probably involved in the development of AD endophenotypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Blossom C. M. Stephan, Denise M. Gaughan, Steven Edland, Villi Gudnason, Lenore J. Launer, Lon R. White
Summary: In this study, neuropathological-based risk scores were used to predict clinical dementia, and different models were identified for predicting neurodegenerative and vascular neuropathology. The findings suggest that there may be shared risk factors and pathways across dementia-related lesions.
ALZHEIMERS & DEMENTIA
(2023)
