Article
Neurosciences
Zhihong Wu, Changning Xie, Haixia Kuang, Jian Wu, Xiao Chen, Huibao Liu, Tao Liu
Summary: The study showed that oxytocin plays a critical role in attenuating neonatal neural death by facilitating GABAergic transmission, which may help regulate the excitatory-inhibitory balance in local neuronal networks in NHIE patients.
Article
Biochemistry & Molecular Biology
Yang Liu, Wen Guo, Si-Lu Hong
Summary: This study found that aerobic exercise can improve neuronal apoptosis and spatial memory in aging mice, and its mechanism may be related to the regulation of the DAPK1 pathway.
Article
Biochemistry & Molecular Biology
Jing Xu, Peng Chen, Chaoqun Yu, Qiangqiang Shi, Susu Wei, Yaxin Li, Hongzhao Qi, Qilong Cao, Chuanlong Guo, Xianggen Wu, Guohu Di
Summary: Hypoxia preconditioning of mesenchymal stromal cells (Hp-MSCs) enhances liver regeneration through secreted exosomes (Hp-Exo), which mediate M2 macrophage polarization by modulating the FOXO1/TLR4 signaling pathway.
Article
Pediatrics
Qun Cai, Xiaoqun Zhang, Liyuan Shen, Honghua Song, Ting Wang
Summary: The study revealed that miR-27a plays a protective role in neonatal HIE rats by reducing infarct volume and brain edema, as well as inhibiting inflammatory factors and infiltrated peripheral immune cells.
TRANSLATIONAL PEDIATRICS
(2022)
Article
Neurosciences
Andrea Ovcjak, Aijiao Xiao, Ji-Sun Kim, Baofeng Xu, Vivian Szeto, Ekaterina Turlova, Ahmed Abussaud, Nai-hong Chen, Steven P. Miller, Hong-Shuo Sun, Zhong-Ping Feng
Summary: In this study, the effects of RyR antagonist, dantrolene, on hypoxic-ischemic (HI) brain injury were investigated in neonatal mice. It was found that dantrolene administration reduced the infarction volume and morphological damage induced by HI and improved functional recovery. In vitro experiments showed that dantrolene protected neuronal cells from oxygen-glucose deprivation-induced cell death and reduced intracellular calcium levels. These findings suggest that dantrolene exerts neuroprotective effects against neonatal HI brain injury and RyRs may play a role in mediating the ionic imbalance induced by HI, making them a potential target for drug development.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pavel Tregub, Natalia Malinovskaya, Elena Hilazheva, Andrey Morgun, Vladimir Kulikov
Summary: In this study, we aimed to investigate the effects of hypercapnia, alone or in combination with hypoxia, on the activation of signaling pathways related to cell apoptosis. The degree of apoptosis was evaluated in both in vivo and in vitro ischemic models. The results showed that hypercapnic component can reduce apoptosis in the ischemic penumbra, decrease the levels of caspase-3, AIF, and Bax, and increase the level of Bcl-2.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Immunology
Yihui Zheng, Tingyu Zhu, Binwen Chen, Yu Fang, Yiqing Wu, Xiaoli Feng, Mengdan Pang, Hongzeng Wang, Jianghu Zhu, Zhenlang Lin
Summary: This study found that diallyl disulfide (DADS) can alleviate brain damage caused by hypoxic-ischemic encephalopathy (HIE) through inhibiting the NLRP3/Caspase-1/IL-1β signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Respiratory System
Ya Yang, Qianmei Tang, Yu Li, Lianjing Dai, Minfeng Li, Yongxin Fu
Summary: The study found that lncRNA ROR promotes the progression of myocardial hypertrophy by competitively binding with miR-145 to regulate the expression of HAX-1.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Cell Biology
P. Brancaccio, S. Anzilotti, O. Cuomo, A. Vinciguerra, M. Campanile, A. Herchuelz, S. Amoroso, L. Annunziato, G. Pignataro
Summary: Researchers are studying endogenous neuroprotective strategies to identify alternative interventions for neonatal hypoxic-ischemic encephalopathy. They found that hypoxic preconditioning can promote neurogenesis and provide neuroprotection by regulating ionic homeostasis.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Lu-Yao Li, Qi Wang, Lu Deng, Zhen Lin, Jing-Jing Lin, Xin-Ye Wang, Tian-Yang Shen, Yi-Hui Zheng, Wei Lin, Pei-Jun Li, Xiao-Qin Fu, Zhen-Lang Lin
Summary: Recent studies have found that chlorogenic acid (CGA) in coffee has a protective effect on the nervous system, but its role in neonatal hypoxic-ischemic brain injury is still unclear. In this study, a newborn mouse model of hypoxic-ischemic brain injury was established and CGA was injected intraperitoneally. The results showed that CGA intervention effectively reduced cerebral infarct volume, relieved cerebral edema, restored brain tissue structure, and promoted axon growth in injured brain tissue.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Jyotirekha Das, Fayaz Shaik Mahammad, Rajanikant Golgodu Krishnamurthy
Summary: In this study, a potential inhibitor of DAPK1-p53 interaction, acarbose, was identified and validated experimentally for its neuroprotective and neuro-regenerative effects against post-ischemic injury. Acarbose showed significant neuroprotection, inhibited DAPK1-p53 interaction, prevented mitochondrial and lysosomal dysfunction, and modulated gene expression related to cell survival, inflammation, and regeneration. This study sheds light on the potential of acarbose as a therapeutic agent for ischemic stroke.