Review
Hematology
Hannah Goulart, John Mascarenhas, Douglas Tremblay
Summary: This review discusses the complications and risk stratification methods in patients with myeloproliferative neoplasms (MPNs) polycythemia vera (PV) and essential thrombocythemia (ET). Current treatment options for low-risk patients are limited, but novel therapies are being investigated.
ANNALS OF HEMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anna Weronska, Elzbieta Papuga-Szela, Elzbieta Broniatowska, Anetta Undas
Summary: This study indicates that NOACs may be effective and safe as secondary prevention of VTE in patients with myeloproliferative neoplasms, with no significant differences related to the type of NOAC. Recurrent thrombotic events and bleeding were observed, but overall mortality was low, suggesting potential benefits of NOAC use in this patient population.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Review
Cell Biology
Roelof H. Bekendam, Katya Ravid
Summary: Platelets play crucial roles in thrombosis and hemostasis. They are also involved in cancer progression and tumor invasion. Activation of platelets by cancers can contribute to metastasis and increase the risk of thrombosis. Platelet secretion provides potential biomarkers for predicting thrombotic risk and tumor progression. Myeloproliferative neoplasms (MPNs) are characterized by abnormal function and number of blood cells, leading to thrombotic and hemorrhagic complications. Mouse models with MPN phenotype have been studied for their thrombotic phenotype, showing the complexity of clotting and bleeding risk. This review focuses on platelets in cancer-associated thrombosis and MPN experimental models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Microbiology
Christina Schjellerup Eickhardt-Dalboge, Anna Cacilia Ingham, Henrik V. Nielsen, Kurt Fuursted, Christen Rune Stensvold, Lee O'Brien Andersen, Morten Kranker Larsen, Lasse Kjaer, Sarah Friis Christensen, Trine Alma Knudsen, Vibe Skov, Christina Ellervik, Lars Ronn Olsen, Hans Carl Hasselbalch, Jens Jorgen Elmer Christensen, Xiaohui Chen Nielsen
Summary: This study investigates the gut microbiota in patients with essential thrombocythemia (ET) and found that they have higher richness and different bacterial composition compared to healthy controls. The relative abundance of certain bacteria within the Firmicutes phylum is lower in ET patients, including an important immunoregulative bacterium Faecalibacterium. These findings suggest a potential role of gut microbiota in immune dysregulation of ET patients.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Christina Schjellerup Eickhardt-Dalbge, Anna Cacilia Ingham, Henrik V. Nielsen, Kurt Fuursted, Christen Rune Stensvold, Lee O'Brien Andersen, Morten Kranker Larsen, Lasse Kjaer, Sarah Friis Christensen, Trine Alma Knudsen, Vibe Skov, Christina Ellervik, Lars Rnn Olsen, Hans Carl Hasselbalch, Jens Jrgen Elmer Christensen, Xiaohui Chen Nielsen
Summary: Essential thrombocythemia (ET) is a type of leukemia characterized by excessive platelet production. Inflammation has been shown to play a vital role in the initiation and progression of other myeloproliferative neoplasms, and the gut microbiota is known to be important in immune system regulation. However, the gut microbiota of ET patients has not been investigated. In this study, we compared the gut microbiota of ET patients with healthy controls, providing new insights into this field. We found significant differences in the gut microbiota of ET patients compared to healthy controls, with ET patients having a lower relative abundance of important immunoregulative bacteria. Furthermore, we observed pronounced gut microbiota signatures in ET patients with the JAK2V617F mutation, confirming the importance of the underlying mutation, immune response, and microbiota composition.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Derek W. Brown, Weiyin Zhou, Youjin Wang, Kristine Jones, Wen Luo, Casey Dagnall, Kedest Teshome, Alyssa Klein, Tongwu Zhang, Shu-Hong Lin, Olivia W. Lee, Sairah Khan, Jacqueline B. Vo, Amy Hutchinson, Jia Liu, Jiahui Wang, Bin Zhu, Belynda Hicks, Andrew St Martin, Stephen R. Spellman, Tao Wang, H. Joachim Deeg, Vikas Gupta, Stephanie J. Lee, Neal D. Freedman, Meredith Yeager, Stephen J. Chanock, Sharon A. Savage, Wael Saber, Shahinaz M. Gadalla, Mitchell J. Machiela
Summary: The study identified 6 germline susceptibility loci and high frequencies of mosaic chromosomal alterations (mCAs) in myelofibrosis cases. The mCAs involving JAK2 were found to be strong promoters of clonal expansion in mutated clones of myelofibrosis cases.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Yingxin Sun, Yifeng Cai, Jiannong Cen, Mingqing Zhu, Jinlan Pan, Qian Wang, Depei Wu, Suning Chen
Summary: Peg-IFN demonstrates promising hematologic and molecular responses in patients with PV and ET, and is safe, effective, and well tolerated in most patients. However, a small percentage of patients had to discontinue treatment due to drug-related toxicity. Further exploration of Peg-IFN alone or in combination with other drugs is needed to minimize treatment-related toxicity and improve tolerability.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Naveen Pemmaraju, Aaron T. Gerds, Jingbo Yu, Shreekant Parasuraman, Anne Shah, Ann Xi, Shambhavi Kumar, Robyn M. Scherber, Srdan Verstovsek
Summary: This study conducted a retrospective analysis of Medicare patients and found that patients with polycythemia vera (PV) and essential thrombocythemia (ET) have increased thrombotic risk. Thrombotic events were associated with an increased mortality risk and shorter median survival time. These findings highlight the importance of thrombosis risk mitigation in the management of PV and ET.
Article
Oncology
Jean Pegliasco, Pierre Hirsch, Christophe Marzac, Francoise Isnard, Jean-Come Meniane, Caroline Deswarte, Philippe Pellet, Celine Lemaitre, Gwendoline Leroy, Graciela Rabadan Moraes, Helene Guermouche, Barbara Schmaltz-Panneau, Florence Pasquier, Chrystelle Colas, Patrick R. Benusiglio, Odile Bera, Jean-Henri Bourhis, Eolia Brissot, Olivier Caron, Samy Chraibi, Pascale Cony-Makhoul, Christine Delaunay-Darivon, Simona Lapusan, Flore Sicre de Fontbrune, Pascal Fuseau, Albert Najman, William Vainchenker, Francois Delhommeau, Jean-Baptiste Micol, Isabelle Plo, Christine Bellanne-Chantelot
Summary: The study revealed that carriers of the 14q32 duplication displayed early clonal hematopoiesis, increasing the risk of myeloid neoplasms. Different pathways were identified in the development of the disease, with one leading to early MPN development and the other directly to AML.
Article
Hematology
Andrew L. Sochacki, Cosmin Adrian Bejan, Shilin Zhao, Ameet Patel, Ashwin Kishtagari, Travis P. Spaulding, Alexander J. Silver, Shannon S. Stockton, Kelly Pugh, R. Dixon Dorand, Manasa Bhatta, Nicholas Strayer, Siwei Zhang, Christina A. Snider, Thomas Stricker, Aziz Nazha, Alexander G. Bick, Yaomin Xu, Michael R. Savona
Summary: Treatment decisions in primary myelofibrosis are usually determined by various prognostic systems, but they do not routinely incorporate patient-specific comorbidities. In this study, the impact of comorbidities on survival was assessed, and it was found that specific comorbidities were associated with inferior survival in primary myelofibrosis patients. By including comorbidities in the risk evaluation, the prognostic capability of genetics-based scoring systems could be enhanced.
Review
Oncology
Douglas Tremblay, Heidi E. Kosiorek, Amylou C. Dueck, Ronald Hoffman
Summary: Thrombosis is a major cause of morbidity and mortality in patients with polycythemia vera and essential thrombocythemia. Current understanding of the risk factors and pathophysiology of thrombosis in these patients is growing, though few therapies have shown effectiveness in reducing thrombotic burden. More studies are needed to evaluate the impact of therapeutic agents on thrombotic events in these myeloproliferative neoplasms.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Jale Yildiz, Hikmettullah Batgi
Summary: This study aimed to investigate whether genetic mutations detected in patients diagnosed with essential thrombocythemia (ET) cause a different clinical phenotype compared to triple-negative ET. The study found that ET with JAK2, CALR, or MPL mutations may have different phenotypic features compared to triple-negative ET, characterized by older age and higher erythrocyte count.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Abdulrahman F. Al-Mashdali, Mahmood B. Aldapt, Alaa Rahhal, Yousef M. Hailan, Israa Elhakeem, Elrazi A. Ali, Waail Rozi, Mohamed A. Yassin
Summary: Philadelphia-negative myeloproliferative neoplasms (MPNs) are rarely diagnosed in pediatrics, leading to limited knowledge about their clinical presentation, mutational status, and complications. This study reviewed the literature and found that pediatric MPNs have different clinical characteristics, vascular and long-term complications, types of driver mutations, and treatment approaches compared to adults.
Review
Oncology
John Mascarenhas, Helene F. E. Gleitz, Helen T. Chifotides, Claire N. Harrison, Srdan Verstovsek, Alessandro Maria Vannucchi, Raajit K. Rampal, Jean-Jacques Kiladjian, William Vainchenker, Ronald Hoffman, Rebekka K. Schneider, Alan F. List
Summary: Myelofibrosis is a myeloproliferative disorder with significant biological and clinical heterogeneity. It can manifest as a cytopenic phenotype or a myeloproliferative phenotype, each with different prognosis and response to treatment. Patients with the cytopenic phenotype have worse outcomes and pose challenges in treatment. Recent data suggest that an innate immune deregulated state may be associated with the cytopenic phenotype, providing potential for novel treatment approaches.
Article
Critical Care Medicine
David Montani, Pierre Thore, Xavier Mignard, Xavier Jais, Athenais Boucly, Mitja Jevnikar, Andrei Seferian, Etienne-Marie Jutant, Vincent Cottin, Elie Fadel, Gerald Simonneau, Laurent Savale, Olivier Sitbon, Marc Humbert
Summary: Precapillary pulmonary hypertension (PH) is a rare and often overlooked complication of myeloproliferative neoplasms (MPNs). This study describes the characteristics and outcomes of MPN-associated PH. Patients with MPN often present with severe hemodynamic impairment and impaired clinical conditions. Chronic thromboembolic PH and group 5 PH are common diagnoses. Thromboendarterectomy can improve survival rates.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Virology
Bahadar A. Srichawla, Maria Garcia-Dominguez, Subtain Zia
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Bahadar S. Srichawla, Manraj Sekhon
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Clinical Neurology
Bahadar S. Srichawla, Raymond M. Catton, Alexander A. Lichtenberg, Nils Henninger
Summary: This article presents a case report of a 17-year-old female with acute pancreatitis who developed acute onset bilateral painless vision loss due to bilateral infarction of the lateral geniculate bodies (LGB), and a systematic review of relevant literature. The review findings indicate that bilateral LGB infarction is a rare cause of vision loss, predominantly affecting women and often associated with systemic diseases.
NEUROLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Bahadar S. Srichawla, Vincent Kipkorir, Muhammad Romail Manan, Arkadeep Dhali, Sebastian Diebel, Tirtha Sawant, Subtain Zia, Diego Carrion-Alvarez, Richard C. Suteja, Khulud Nurani, Mihnea-Alexandru Gaman
Summary: Neurotropic viruses pose a threat to human populations, causing various neurological diseases such as parkinsonism, encephalitis, flaccid myelitis, and Guillain-Barre syndrome. Neuroinvasion can occur through transneural transmission, blood brain barrier dysfunction, or infected immune cell trafficking into the central nervous system (CNS). The ability of the virus to evade direct detection in cerebrospinal fluid (CSF) does not exclude CNS involvement, as neuroevasive mechanisms may still be present.
ANNALS OF MEDICINE AND SURGERY
(2023)
Review
Oncology
Mihnea-Alexandru Gaman, Matei-Alexandru Cozma, Muhammad Romail Manan, Bahadar S. Srichawla, Arkadeep Dhali, Sajjad Ali, Ahmed Nahian, Andrew C. Elton, L. V. Simhachalam Kutikuppala, Richard Christian Suteja, Sebastian Diebel, Amelia Maria Gaman, Camelia Cristina Diaconu
Summary: Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by excessive production of mature myeloid cells. Classical MPNs, such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, have a tendency to develop thrombotic complications at unusual sites. The pathogenesis of thrombotic events in MPNs is complex and involves endothelial injury, leukocyte adhesion, genetic mutations, and other factors. In this review, we discuss the epidemiology, pathogenesis, histopathology, risk factors, classification, clinical presentation, diagnosis, and management of Budd-Chiari syndrome in Philadelphia-negative MPNs.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Bahadar S. Srichawla, Jared Quast, Peter Pacut, Shravan Sivakumar, Maria A. Garcia-Dominguez, Jillian Belgrad, Ashwin Panda, Sara Carbone, Delia T. Sanders, Eli Min, Nicole T. Hayes, Abigail Bose, Vanessa Lee, Mehdi Ghasemi
Summary: Amid the COVID-19 pandemic, a retrospective analysis of ICU patients revealed prognostic factors associated with mortality. Age 60 or older, impaired consciousness, lung disease, elevated INR and BUN levels were identified as contributing factors to increased mortality. Surprisingly, symptoms such as dizziness/lightheadedness, myalgia, and headache were associated with higher survival rates.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Letter
Clinical Neurology
Bahadar S. Srichawla, Jared Quast
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Bahadar S. Srichawla, Kajol Doshi, Seyedeh N. Cheraghi, Shravan Sivakumar
Summary: A systematic review and meta-analysis revealed that breast cancer is often associated with neuromyelitis optica spectrum disorder (NMOSD), with the diagnosis of breast cancer occurring more often after the onset of NMOSD symptoms. Older women with a new diagnosis of NMOSD should be considered for frequent breast cancer screening.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Bahadar S. Srichawla, Hande Can, Wissam Deeb
Summary: Craniocervical spine meningiomas are rare with non-specific motor or sensory symptoms. Severe symptoms like respiratory distress and quadriparesis are possible due to the critical location. We described the clinical presentation, neuroimaging findings, diagnostic challenges, and management of a craniocervical junction meningioma in a woman in her 30s. A total of 24 similar cases were found in a literature review.
Article
Medicine, General & Internal
Bahadar S. Srichawla, Shravan Sivakumar, Seyedeh N. Cheraghi, Vincent Kipkorir, Maria A. Garcia-Dominguez
Summary: This is a rare case report of a 71-year-old woman with neuromyelitis optica, an autoimmune inflammatory disorder affecting the central nervous system, in a paraneoplastic context. The patient had a history of triple-negative infiltrating ductal breast carcinoma and presented with respiratory failure and underwent a cervical laminectomy. She experienced symptoms such as breast pain, lower extremity weakness, and neck pain.
SAGE OPEN MEDICAL CASE REPORTS
(2023)
Article
Medicine, General & Internal
Bahadar S. Srichawla, Eduardo Andrade, Vincent Kipkorir
Summary: Brain calcifications, also known as Fahr's disease, is a rare neurological disorder with diverse clinical symptoms and unclear pathophysiology. This case series highlights the different etiologies and clinical presentations of brain calcifications, including genetic and endocrine causes. Future research should focus on identifying genetic mutations, understanding molecular pathways, and improving diagnostic techniques to enhance diagnosis and management of this intricate neurological disorder.
SAGE OPEN MEDICAL CASE REPORTS
(2023)
Review
Medicine, General & Internal
Bahadar S. Srichawla
Summary: A 59-year-old female developed diffuse abdominal pain two days after receiving the mRNA-1273 COVID-19 vaccine. A CT angiogram revealed the presence of vascular irregularities consistent with polyarteritis nodosa (PAN). The patient was treated with intravenous methylprednisolone followed by oral methotrexate for immunosuppressive maintenance therapy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Bahadar S. Srichawla, Vincent Kipkorir, Lawrence Hayward
Summary: Toxic leukoencephalopathy can lead to malignant catatonia, which is associated with heart rate variability (HRV) as a marker of autonomic nervous system function.
Article
Medicine, General & Internal
Bahadar S. Srichawla, Ton Fang, Abigail Bose, Vincent Kipkorir, Annie Ferris
Summary: Optimal anticoagulation management in patients with atrial fibrillation during acute ischemic stroke is complex. Mechanical thrombectomy has shown effectiveness in managing rare large multi-vessel occlusions.
JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS
(2023)
