Article
Pharmacology & Pharmacy
Sang Zhu, Yan Rong, Tony K. L. Kiang
Summary: In HepaRG cells, p-cresol is relatively potent toxicant, while glucuronidation is unlikely to be associated with its toxic effects.
Article
Oncology
Xiaohong Chen, Fangfang Xiang, Xuesen Cao, Jianzhou Zou, Boheng Zhang, Xiaoqiang Ding
Summary: The study found that p-cresol had no effect on the migration and invasion of renal cancer cells, but it promoted these behaviors in liver cancer cells. This suggests that p-cresol may be responsible for the malignant behavior of liver cancer cells.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Cell Biology
Hai-Yan Fu, Jia-Min Xu, Xin Ai, Fu-Tao Dang, Xu Tan, Hai-Yan Yu, Juan Feng, Wen-Xia Yang, Hai-Tao Ma, Rong-Fang Tu, Ajay Kumar Gupta, Lagan Kumar Manandhar, Wei-Min Bao, Ying-Mei Tang
Summary: The study suggests that p-Cresol sulfate (PCS), a metabolite of Clostridium-metabolized tyrosine, can reduce inflammation in primary biliary cholangitis (PBC). This finding may contribute to the development of effective clinical strategies for treating PBC.
Article
Biochemistry & Molecular Biology
Maurice Tust, Julian Peter Mueller, Dietmar Fischer, Dirk Grundemann
Summary: Chronic kidney disease is a global health concern. This study investigates the transport mechanisms of uremic toxins, providing insights into potential treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Rossella Di Paola, Ananya De, Raafiah Izhar, Marianna Abate, Silvia Zappavigna, Anna Capasso, Alessandra F. Perna, Antonella La Russa, Giovambattista Capasso, Michele Caraglia, Mariadelina Simeoni
Summary: Chronic kidney disease (CKD) leads to the accumulation and production of uremic toxins, which activate harmful processes. Gut dysbiosis is common in CKD patients and promotes the growth of certain bacteria that release substances like p-Cresol, Indoxyl Sulfate, and p-Cresyl Sulfate. These substances play a role in chronic inflammation, free radical production, and immune dysfunction, potentially contributing to colon cancer development. Further research is needed to fully understand the mechanisms behind this association.
Article
Microbiology
Patricia Bermudez-Martin, Jerome A. J. Becker, Nicolas Caramello, Sebastian P. Fernandez, Renan Costa-Campos, Juliette Canaguier, Susana Barbosa, Laura Martinez-Gili, Antonis Myridakis, Marc-Emmanuel Dumas, Aurelia Bruneau, Claire Cherbuy, Philippe Langella, Jacques Callebert, Jean-Marie Launay, Joelle Chabry, Jacques Barik, Julie Le Merrer, Nicolas Glaichenhaus, Laetitia Davidovic
Summary: The microbial metabolite p-Cresol induces ASD-like behavioral symptoms in mice, particularly social behavior deficits, and is associated with decreased activity of central dopamine neurons. These behavioral deficits induced by p-Cresol can be transferred via fecal microbiota transplantation and are dependent on changes in microbiota composition.
Article
Biochemical Research Methods
Luis A. P. Silva, Stefano Campagnolo, Sara R. R. Fernandes, Sara S. S. Marques, Luisa Barreiros, Benedita Sampaio-Maia, Marcela A. Segundo
Summary: A rapid and sensitive HPLC method with fluorescence detection was developed for simultaneous quantification of protein-bound uremic toxins in human plasma. The method showed good accuracy and precision, and was successfully applied to analyze plasma samples from control subjects and CKD patients.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Shaghayegh Sadaati, Sana Daneshamouz, Jumanah Bahig, Ahmed Shoker, Amira Abdelrasoul
Summary: This study investigated the detoxification of PCS in serum of HD patients using a biocompatible laccase enzyme and evaluated it through molecular docking, UV-Vis spectroscopy, and GC-MS. The results showed that the laccase effectively removed PCS and formed m-cresol. The affinity energy of detoxification products was lower than that of PCS, and the toxicity indexes were lower as well. Additionally, these small compounds can be easily removed by HD compared to PCS.
JOURNAL OF BIOTECHNOLOGY
(2023)
Article
Immunology
Mark A. Harrison, Harparkash Kaur, Brendan W. Wren, Lisa F. Dawson
Summary: Clostridioides difficile is the leading cause of antibiotic-associated diarrhea, producing high levels of the antimicrobial compound para-cresol through different mechanisms. Certain strains show higher levels of para-cresol production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Stacie Summers, Jessica Quimby, Jason Gagne, Michael Lappin
Summary: This study evaluated the effects of feeding healthy adult cats with variable protein concentrations on the fecal microbiome and serum concentrations of gut-derived toxins. The results showed that a high-protein diet increased the serum concentrations of p-cresol sulfate and decreased the relative abundance of Bifidobacterium in the gut. This suggests that dietary protein concentration can affect the gut microbial community and toxin production.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuanpeng Zheng, Naika Z. Prince, Lucia N. Peralta Marzal, Sabbir Ahmed, Johan Garssen, Paula Perez Pardo, Aletta D. Kraneveld
Summary: This study reveals the mechanisms of pCS in the pathogenesis of autism spectrum disorder (ASD) by reducing the expression or maturation of ADAM10 and ADAM17, resulting in decreased inflammatory response and phagocytic activity of microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Li-Chun Ho, Ting-Yun Wu, Tsun-Mei Lin, Hung-Hsiang Liou, Shih-Yuan Hung
Summary: Despite high plasma levels of IL-1 beta in HD patients, caspase-1 and IL-1 beta in the PBMCs of HD patients were predominantly immature and not secreted in response to the canonical stimulus. Additionally, IS alone facilitated inflammasome-independent secretion of IL-1 beta from macrophages, but IS exposure before induction reduced the inducibility of the NLRP3 inflammasome, characterized by insufficient maturation of caspase-1.
Article
Medicine, General & Internal
Witchayapon Kamprom, Tulyapruek Tawonsawatruk, Sumana Mas-Oodi, Korrarit Anansilp, Manoch Rattanasompattikul, Aungkura Supokawej
Summary: Protein-bound uremic toxins like p-cresol and indoxyl sulfate inhibit osteoblastic differentiation of mesenchymal stem cells, leading to impaired mineralization and down-regulation of collagen type I. This effect is partially mediated through the activation of senescence-associated genes, ultimately causing a gradual deterioration of osteogenesis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuyin Zhou, Zheting Bi, Matthew J. Hamilton, Li Zhang, Rui Su, Michael J. Sadowsky, Sabita Roy, Alexander Khoruts, Chi Chen
Summary: This study investigated the metabolic changes induced by FMT in rCDI patients through metabolomic analysis of urine samples. The results showed that the concentration of p-cresol sulfate in urine rapidly increased, making it a potential therapeutic indicator for the effectiveness of antibiotics and FMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Ina Nemet, Masanori Funabashi, Xinmin S. Li, Mohammed Dwidar, Naseer Sangwan, Sarah M. Skye, Kymberleigh A. Romano, Tomas Cajka, Brittany D. Needham, Sarkis K. Mazmanian, Adeline M. Hajjar, Federico E. Rey, Oliver Fiehn, W. H. Wilson Tang, Michael A. Fischbach, Stanley L. Hazen
Summary: pCS and IS, gut microbiome-derived metabolites, are associated with cardiovascular disease risks and all-cause mortality. Microbial genes involved in the production of these metabolites can confer pro-thrombotic phenotype in vivo. Therapeutic targeting of gut microbial pathways may be a rational approach for CVD treatment.
Letter
Urology & Nephrology
Tariq Shafi, Andrew S. Levey, Josef Coresh
AMERICAN JOURNAL OF KIDNEY DISEASES
(2016)
Article
Urology & Nephrology
Naya El Hage, Bernard G. Jaar, Alan Cheng, Chloe Knight, Elena Blasco-Colmenares, Luis Gimenez, Eliseo Guallar, Tariq Shafi
Article
Urology & Nephrology
Stephanie M. Toth-Manikowski, Surekha Mullangi, Seungyoung Hwang, Tariq Shafi
Article
Urology & Nephrology
Tariq Shafi, Andrew S. Levey
ADVANCES IN CHRONIC KIDNEY DISEASE
(2018)
Editorial Material
Urology & Nephrology
Morgan E. Grams, Tariq Shafi, Eugene P. Rhee
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Editorial Material
Urology & Nephrology
Tariq Shafi, Eliseo Guallar
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Letter
Urology & Nephrology
Jiun-Ruey Hu, Morgan E. Grams, Josef Coresh, Seungyoung Hwang, Csaba P. Kovesdy, Eliseo Guallar, Eugene P. Rhee, Tariq Shafi
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Editorial Material
Urology & Nephrology
Tariq Shafi, Dana C. Miskulin
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Zihe Zheng, Sushrut S. Waikar, Insa M. Schmidt, J. Richard Landis, Chi-yuan Hsu, Tariq Shafi, Harold Feldman, Amanda H. Anderson, Francis P. Wilson, Jing Chen, Hernan Rincon-Choles, Ana C. Ricardo, Georges Saab, Tamara Isakova, Radhakrishna Kallem, Jeffrey C. Fink, Panduranga S. Rao, Dawei Xie, Wei Yang
Summary: Using consensus clustering, three distinct subgroups of chronic kidney disease were identified, each associated with different risks of important clinical outcomes. Further investigation of patient subgroups and biomarkers may lead to advancements in precision medicine.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Kendra E. Wulczyn, Sophia H. Zhao, Eugene P. Rhee, Sahir Kalim, Tariq Shafi
Summary: This study found an association between decline in kidney function and worsening of uremic symptom severity in patients with chronic kidney disease. However, the magnitude of these changes is small and of uncertain clinical significance.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anna Jovanovich, Xuan Cai, Rebecca Frazier, Josh D. Bundy, Jiang He, Panduranga Rao, Claudia Lora, Mirela Dobre, Alan Go, Tariq Shafi, Harold Feldman, Eugene P. Rhee, Makoto Miyazaki, Tamara Isakova, Michel Chonchol
Summary: Through the CRIC study, it was found that there was no association between DCA and CAC in participants. DCA was not associated with prevalent, incident, or progression of CAC in the CRIC study participants.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Tariq Shafi, Xiaoqian Zhu, Seth T. Lirette, Andrew D. Rule, Thomas Mosley, Kenneth R. Butler, Michael E. Hall, Pradeep Vaitla, James J. Wynn, Maria Clarissa Tio, Neville R. Dossabhoy, Eliseo Guallar, Javed Butler
Summary: The study found significant individual-level differences between mGFR and eGFR, particularly in chronic kidney disease staging.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Urology & Nephrology
Kendra E. E. Wulczyn, Eugene P. P. Rhee, Leslie Myint, Sahir Kalim, Tariq Shafi
Summary: This study evaluated the risk factors for pruritus in patients with CKD and found that in addition to lower eGFR, other factors such as age, BMI, diabetes, and smoking were associated with an increased risk of pruritus.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Jessica Fitzpatrick, Stephen M. Sozio, Bernard G. Jaar, Michelle M. Estrella, Dorry L. Segev, Tariq Shafi, Jose M. Monroy-Trujillo, Rulan S. Parekh, Mara A. McAdams-DeMarco
Summary: Frailty was found to be independently associated with prolonged postdialysis recovery in adults new to hemodialysis. Future studies should evaluate the impact of frailty-targeted interventions on recovery time to enhance clinical outcomes.
Article
Urology & Nephrology
Monique E. Cho, Carol Sweeney, Nora Fino, Tom Greene, Nirupama Ramkumar, Yufeng Huang, Ana C. Ricardo, Tariq Shafi, Rajat Deo, Amanda Anderson, Katherine T. Mills, Alfred K. Cheung
Summary: In patients with chronic kidney disease (CKD), plasma concentrations of prorenin and renin showed a decreasing trend, especially in those with severe conditions at baseline. Women and non-Hispanic blacks had lower prorenin and renin values at year 1, while diabetes, lower eGFR, and use of certain medications were associated with higher levels of prorenin and renin.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)