Article
Physiology
Derrick J. E. Groom, Betsy Black, Jessica E. Deakin, Joely G. Desimone, M. Collette Lauzau, Bradley P. Pedro, Chad R. Straight, Kimberly P. Unger, Mark S. Miller, Alexander R. Gerson
Summary: Bird flight muscle can lose up to 20% of its mass during migratory flight due to protein catabolism, which can be exacerbated under dehydrating conditions. This study examined the effects of exercise and environment-induced protein catabolism on muscle. The results showed that although dry conditions slowed down the crossbridge kinetics of the muscle, aerobic and contractile function were largely preserved after 6 hours of exercise.
PHYSIOLOGICAL REPORTS
(2023)
Article
Physiology
Rafael L. Rovina, Alisson L. da Rocha, Bruno B. Marafon, Jose R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Adelino S. R. da Silva
Summary: In the study of acute response to endurance exercise, upregulation of Nr1d1 mRNA levels in oxidative muscle was observed, along with enhanced expression of genes related to mitochondrial biogenesis and atrophy. The investigation also revealed that higher Nr1d1 gene expression in muscle was associated with upregulation of AMPK signaling and mitochondrial-related genes in isogenic mice families.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Physiology
Douglas W. Van Pelt, Marcus M. Lawrence, Benjamin F. Miller, Timothy A. Butterfield, Esther E. Dupont-Versteegden
Summary: Massage is believed to have many health benefits, and recent research has started to investigate the physiological and clinical effects of massage in a controlled manner. Studies support the hypothesis that massage can be used as mechanotherapy to improve biologically relevant adaptations in skeletal muscle and muscle properties.
EXERCISE AND SPORT SCIENCES REVIEWS
(2021)
Article
Geriatrics & Gerontology
Jiling Liang, Hu Zhang, Zhengzhong Zeng, Jun Lv, Jielun Huang, Xiaowen Wu, Minghui Wang, Jiahao Xu, Jingjing Fan, Ning Chen
Summary: Exercise interventions may serve as a potential treatment for sarcopenia by modulating molecular mechanisms associated with muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Biochemistry & Molecular Biology
Dumitru Constantin-Teodosiu, Despina Constantin
Summary: Muscle fatigue can decrease the capacity of muscles to complete tasks over time, with short-lasting fatigue often caused by overtraining, undertraining, or physical injury, while persistent and severe fatigue may be associated with pathological states or chronic exposure to certain substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Wei Wang, Ming Li, Zehao Chen, Lai Xu, Mengyuan Chang, Kexin Wang, Chunyan Deng, Yun Gu, Songlin Zhou, Yuntian Shen, Feng Tao, Hualin Sun
Summary: Pathophysiological changes of skeletal muscle can cause muscle atrophy and dysfunction, greatly affecting quality of life. Extracellular vesicles (EVs) are involved in the pathophysiological processes of skeletal muscle. EVs play a role in skeletal muscle growth, regeneration, and atrophy by delivering bioactive molecules. EVs have potential as biomarkers and therapeutic carriers for skeletal muscle diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi
Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elisa Duranti, Chiara Villa
Summary: ALS is a fatal disease characterized by the loss of motor neurons, leading to muscle damage and paralysis. Muscle research plays a crucial role in understanding the molecular mechanisms and developing treatments for this disease.
Article
Cardiac & Cardiovascular Systems
Ephraim B. Winzer, Antje Augstein, Antje Schauer, Stephan Mueller, Tina Fischer-Schaepmann, Keita Goto, Jennifer Hommel, Emeline M. van Craenenbroeck, Ulrik Wisloff, Burkert Pieske, Martin Halle, Axel Linke, Volker Adams
Summary: Both moderate continuous exercise training and high-intensity interval training can improve exercise capacity for patients with heart failure, but only high-intensity interval training has significant effects on skeletal muscle proteins related to energy metabolism and satellite cells.
CIRCULATION-HEART FAILURE
(2022)
Review
Cell Biology
Gokhan Burcin Kubat, Esmaa Bouhamida, Oner Ulger, Ibrahim Turkel, Gaia Pedriali, Daniela Ramaccini, Ozgur Ekinci, Berkay Ozerklig, Ozbeyen Atalay, Simone Patergnani, Beyza Nur Sahin, Giampaolo Morciano, Meltem Tuncer, Elena Tremoli, Paolo Pinton
Summary: Skeletal muscle is a dynamic and plastic tissue that plays a vital role in movement, posture, and force production. It functions as an endocrine organ capable of producing and secreting bioactive molecules. Various pathological conditions can disrupt the balance between muscle protein synthesis and degradation, leading to skeletal muscle atrophy.
Article
Biochemistry & Molecular Biology
Xiaoguang Liu, Miaomiao Xu, Yang Yu, Yingjie Chen, Xinyu Weng, Lin Zhu
Summary: PD-1 plays an important role in cisplatin-induced skeletal muscle atrophy, with PD-1 knockout exacerbating muscle wasting and influencing inflammation and oxidative stress in muscles.
Article
Oncology
Yang Yang, Xuege Yang, Yating Huang, Sujuan Liu, Yanmei Niu, Li Fu
Summary: This study investigated the protective effects of resistance exercise in dexamethasone-induced muscle atrophy and found that Sestrin2 plays a vital role in this process. Resistance exercise increased Sestrin2 expression, which improved muscle atrophy by inhibiting the activation of the ubiquitin-proteasome pathway and MSTN/Smad signaling pathways.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Yanan Ji, Ming Li, Mengyuan Chang, Ruiqi Liu, Jiayi Qiu, Kexin Wang, Chunyan Deng, Yuntian Shen, Jianwei Zhu, Wei Wang, Lingchi Xu, Hualin Sun
Summary: Various diseases can cause skeletal muscle atrophy, often accompanied by inflammation and other cellular changes. The underlying mechanisms of inflammation in muscle atrophy are complex and not completely understood. This review highlights the protein degradation pathways, pro-inflammatory cytokines, and signaling pathways involved in muscle atrophy. It also explores the effects of inflammation on the hypothalamic-pituitary-adrenal axis and fat metabolism. Additionally, the paper summarizes recent advancements in anti-inflammatory drugs for the treatment and prevention of muscle atrophy.
Article
Food Science & Technology
Min-Kyeong Lee, Hyeon Hak Jeong, Myeong-Jin Kim, Heeyeon Ryu, Jiwon Baek, Bonggi Lee
Summary: Glucocorticoid excess is a critical factor contributing to muscle atrophy, while applying mechanical load and providing adequate nutrients can prevent and improve muscle wasting.
Article
Cell Biology
Feng-Min Zhang, Hao-Fan Wu, Han-Ping Shi, Zhen Yu, Cheng-Le Zhuang
Summary: Sarcopenia is a systemic skeletal muscle disorder that often affects the elderly population and is more common in cancer patients. It not only changes body composition but also leads to increased complications, reduced treatment efficacy, and shortened survival.
AGEING RESEARCH REVIEWS
(2023)