Multi-step synthesis of novel 2-methyl-3-carboxamide-4-quinolones and an enhanced sampling simulation method to identify potentiators for cystic fibrosis
出版年份 2023 全文链接
标题
Multi-step synthesis of novel 2-methyl-3-carboxamide-4-quinolones and an enhanced sampling simulation method to identify potentiators for cystic fibrosis
作者
关键词
-
出版物
Materials Today Chemistry
Volume 33, Issue -, Pages 101731
出版商
Elsevier BV
发表日期
2023-10-01
DOI
10.1016/j.mtchem.2023.101731
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Explicit-solvent molecular dynamics simulations revealed conformational regain and aggregation inhibition of I113T SOD1 by Himalayan bioactive molecules
- (2021) Sachin Kumar et al. JOURNAL OF MOLECULAR LIQUIDS
- Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity
- (2020) Lionel Froux et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- R117H-CFTR function and response to VX-770 correlate with mRNA and protein expression in intestinal organoids
- (2020) Peter Van Mourik et al. Journal of Cystic Fibrosis
- Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis
- (2020) Heledd H Jarosz-Griffiths et al. eLife
- CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine
- (2020) Miquéias Lopes-Pacheco Frontiers in Pharmacology
- Structural identification of a hotspot on CFTR for potentiation
- (2019) Fangyu Liu et al. SCIENCE
- Cystic Fibrosis: Pathophysiology of Lung Disease
- (2019) Christelle Bergeron et al. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
- Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent
- (2018) Steven E. Van der Plas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
- (2018) Masatoshi Kudo et al. LANCET
- Design and virtual screening of novel fluoroquinolone analogs as effective mutant DNA GyrA inhibitors against urinary tract infection-causing fluoroquinolone resistant Escherichia coli
- (2018) Sakthivel Balasubramaniyan et al. RSC Advances
- Molecular Dynamics Simulation for All
- (2018) Scott A. Hollingsworth et al. NEURON
- Molecular structure of the ATP-bound, phosphorylated human CFTR
- (2018) Zhe Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Efficient Geometry Minimization and Transition Structure Optimization Using Interpolated Potential Energy Surfaces and Iteratively Updated Hessians
- (2017) Jingjing Zheng et al. Journal of Chemical Theory and Computation
- Direct Synthesis of 4-Quinolones via Copper-Catalyzed Anilines and Alkynes
- (2017) Xuefeng Xu et al. ORGANIC LETTERS
- The diagnosis of cystic fibrosis
- (2017) Kris De Boeck et al. PRESSE MEDICALE
- A Concise and Highly Enantioselective Total Synthesis of (+)-anti- and (−)-syn-Mefloquine Hydrochloride: Definitive Absolute Stereochemical Assignment of the Mefloquines
- (2015) Ettore J. Rastelli et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source
- (2015) Linda Åkerbladh et al. JOURNAL OF ORGANIC CHEMISTRY
- New pharmacological approaches for cystic fibrosis: Promises, progress, pitfalls
- (2015) Scott C. Bell et al. PHARMACOLOGY & THERAPEUTICS
- Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiators Protect G551D but Not ΔF508 CFTR from Thermal Instability
- (2014) Xuehong Liu et al. BIOCHEMISTRY
- g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations
- (2014) Rashmi Kumari et al. Journal of Chemical Information and Modeling
- Discovery of N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator
- (2014) Sabine Hadida et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors
- (2013) Giuseppe Manfroni et al. JOURNAL OF MEDICINAL CHEMISTRY
- How maltose influences structural changes to bind to maltose-binding protein: Results from umbrella sampling simulation
- (2013) Nahren Manuel Mascarenhas et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Design, Synthesis, and Evaluation of Novel 3,6-Diaryl-4-aminoalkoxyquinolines as Selective Agonists of Somatostatin Receptor Subtype 2
- (2011) Scott E. Wolkenberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- CFTR: folding, misfolding and correcting the ΔF508 conformational defect
- (2011) Gergely L. Lukacs et al. TRENDS IN MOLECULAR MEDICINE
- Microwave-Assisted Synthesis of Polysubstituted 4-Quinolones from Deprotonated α-Aminonitriles
- (2010) Alexandra Romek et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTRMutation
- (2010) Frank J. Accurso et al. NEW ENGLAND JOURNAL OF MEDICINE
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- A Mild, One-Pot Synthesis of 4-Quinolones via Sequential Pd-Catalyzed Amidation and Base-Promoted Cyclization†
- (2008) Jinkun Huang et al. ORGANIC LETTERS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started