Article
Medicine, Research & Experimental
Weicheng Liang, Chuanjian Shi, Weilong Hong, Panlong Li, Xue Zhou, Weiming Fu, Lizhu Lin, Jinfang Zhang
Summary: The study uncovered the role of lncRNA-DAW in hepatocellular carcinoma, showing its regulation by a liver-specific super-enhancer and the transcription factor HNF4G. It was found to promote tumor growth and activate the Wnt/β-catenin pathway by interacting with EZH2. This study suggests lncRNA-DAW as a potential oncogene and diagnostic biomarker in liver cancer.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Rui Wang, Jian Liu, Kai Li, Ganghua Yang, Sisi Chen, Jie Wu, Xinming Xie, Hong Ren, Yamei Pang
Summary: SETD1A is significantly upregulated in NSCLC, and its overexpression predicts a poor prognosis for patients. Functional experiments demonstrate that SETD1A positively regulates cancer stem cell properties and negatively regulates cisplatin sensitivity in NSCLC cells through the Wnt/beta-catenin pathway. Additionally, SETD1A interacts with and stabilizes beta-catenin to positively regulate the Wnt/beta-catenin pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rocio Jimenez-Guerrero, Alejandro Belmonte-Fernandez, M. Luz Flores, Monica Gonzalez-Moreno, Begona Perez-Valderrama, Francisco Romero, Miguel A. Japon, Carmen Saez
Summary: This study reveals the role of the Wnt/β-catenin pathway in paclitaxel resistance in bladder cancer cells with CSC-like properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Mosha Cheng, Qing Zhou
Summary: The study revealed that under inflammation, overexpression of EZH2 suppressed PDLSC osteogenesis through the Wnt/beta-catenin pathway, as well as inhibited the levels of proinflammatory cytokines. These findings provide new insights into the physiological and pathological mechanisms of PDLSC osteogenesis.
CELLS TISSUES ORGANS
(2021)
Article
Oncology
Xin Kong, Hong Peng, Peng Liu, Xiao Fu, Ni Wang, Dazhi Zhang
Summary: Programmed death ligand 1 (PD-L1) plays a crucial role in the development of hepatocellular carcinoma (HCC) by regulating epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-like properties. PD-L1 enhances liver CSC phenotypes and tumorigenicity through the activation of stemness genes and the expansion of the CD133(+) cell population. PD-L1 also promotes cell motility, invasion, and EMT process in HCC cells, while suppression of PD-L1 has the opposite effect. PD-L1 interacts with serum and glucocorticoid kinase 2 (SGK2) to activate the SGK2/beta-catenin signaling pathway, thereby inducing EMT and acquisition of a stem cell phenotype in liver cancer cells.
Article
Cell Biology
Jingjing Fa, Xiaoqing Zhang, Xiaoping Zhang, Ming Qi, Xingyu Zhang, Qihua Fu, Zhuoming Xu, Yunqian Gao, Bo Wang
Summary: Congenital heart defects are the most common birth defects worldwide, with 22q11.2 deletion syndrome often associated with conotruncal malformations. A study revealed that the lncRNA lnc-TSSK2-8 plays a significant role in cardiac outflow tract development, activating the canonical Wnt/beta-catenin signaling pathway, potentially contributing to the etiology of CNV-related CHD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Yu, Cong Shen, Meng Lin, Xia Chen, Xiuliang Dai, Zhiran Li, Yunhao Wu, Yangbo Fu, Jinxing Lv, Xiaoyan Huang, Bo Zheng, Fei Sun
Summary: In this study, we identified BMI1 as a key regulator of spermatogonial stem cell (SSC) maintenance. BMI1 represses target genes by increasing H2AK119ub and reducing H3K4me3 in SSCs. Additionally, BMI1 inhibition activates Wnt signaling and promotes nuclear translocation of beta-catenin in SSCs. Suppression of Wnt/beta-catenin signaling restores SSC maintenance in BMI1-deficient SSCs. Our findings not only reveal a novel mechanism for BMI1 in SSC maintenance, but also provide a potential strategy for treating male infertility.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hua Yu, Jun He, Wei Liu, Shuya Feng, Li Gao, Yingying Xu, Yawei Zhang, Xuyang Hou, Yan Zhou, Leping Yang, Xiongjun Wang
Summary: AF9 protein is up-regulated in liver cancer and correlates with tumor stage and poor prognosis. It forms a complex with HIF1 alpha and acetylated cMyc to promote hypoxia tolerance and glycolysis gene expression.
Article
Medicine, Research & Experimental
Qi Jiang, Yong-Hua Lei, Dewi Chrystal Krishnadath, Bing-Yu Zhu, Xiong-Wen Zhou
Summary: The study found that curcumin can protect against osteoporosis by regulating the EZH2/Wnt/beta-Catenin pathway, improving bone density and structure in the mandible and femur, and promoting bone formation. Experimental results on ovariectomized rats suggest that curcumin has a protective effect.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biology
Cheng-Yu Tsai, Huey-Jiun Ko, Chi-Ying F. Huang, Ching-Yi Lin, Shean-Jaw Chiou, Yu-Feng Su, Ann-Shung Lieu, Joon-Khim Loh, Aij-Lie Kwan, Tsung-Hsien Chuang, Yi-Ren Hong
Summary: This study revealed that fractionated IR could induce GSCs with stemness phenotype through P62-mediated autophagy via the Wnt/beta-catenin pathway for radioresistance. Pharmacological inhibition of autophagy can impair GSC cell growth by decreasing the expression levels of stemness markers.
Article
Oncology
Hui Hua, Tao Su, Linyu Han, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang
Summary: This study identified a novel oncogenic lncRNA, LINC01226, transcribed from the 1p35.2 GC-risk locus, which is highly expressed in GC and associated with worse prognosis. LINC01226 promotes proliferation, migration, and metastasis of GC cells and activates the Wnt/beta-catenin signaling pathway.
Article
Cell Biology
Shouzhang Yang, Xiaojiao Ruan, Bingren Hu, Jinfu Tu, Huajie Cai
Summary: This study aimed to investigate the function of long noncoding RNA SNHG9 in the self-renewal and tumorigenesis of liver cancer stem cells (CSCs). The study found that SNHG9 was highly expressed in liver cancer clinical samples and cells, and its interference prevented the formation of colonies and spheroids in liver CSCs and primary liver cancer cells, reducing tumor volume and weight. By binding to EZH2, SNHG9 down-regulated PTEN levels, promoting the self-renewal and tumor formation of liver CSCs and exacerbating hepatocellular carcinoma progression.
CELL AND TISSUE RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Lei Ren, Hong Deng, Yu Jiang, Chunfeng Liu
Summary: This study investigates the dual regulation of EZH2 and KDM6A in the upstream modulation of SALL4, promoting GC cell progression via the Wnt/beta-catenin pathway. The results show that SALL4 is upregulated in GC cells and regulates the progression and invasion of GC cells through the Wnt/beta-catenin pathway, which can be separately upregulated or downregulated by KDM6A or EZH2.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Oncology
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, April L. Solon, Donald W. Little III, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, April A. Apfelbaum, Michelle Vinco, Alda Wakamatsu, Beatriz M. P. Mariani, Larissa Costa Amorim, Ana Claudia Latronico, Berenice B. Mendonca, Maria Claudia N. Zerbini, Elizabeth R. Lawlor, Ryoma Ohi, Richard J. Auchus, William E. Rainey, Suely K. N. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida Barisson Villares Fragoso, David T. Breault, Antonio Marcondes Lerario, Gary D. Hammer
Summary: In adrenocortical carcinoma, 3-catenin regulates cellular differentiation and cancer growth by binding with SF1 and EZH2. Inhibiting EZH2 reverses differentiation and restrains cancer growth.
Article
Biochemistry & Molecular Biology
Kibrom M. Alula, Yaritza Delgado-Deida, Dakota N. Jackson, K. Venuprasad, Arianne L. Theiss
Summary: PHB1 plays a role in inhibiting the Wnt/β-catenin pathway to influence the development of intestinal tumorigenesis by regulating AXIN1 expression and the beta-catenin destruction complex. Induction of nuclear PHB1 trafficking provides a novel therapeutic option to influence AXIN1 expression and the beta-catenin destruction complex in Wnt-driven intestinal tumorigenesis.
Article
Biochemistry & Molecular Biology
Buqing Ye, Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Dongdong Zhang, Wei Wu, Pingping Zhu, Yanying Wang, Shuo Wang, Pengyan Xia, Ying Du, Shu Meng, Guanling Huang, Jiayi Wu, Runsheng Chen, Yong Tian, Zusen Fan
Article
Biochemistry & Molecular Biology
Zhenzhen Chen, Yanfeng Gao, Lintong Yao, Yating Liu, Lan Huang, Zhongyi Yan, Wenshan Zhao, Pingping Zhu, Haibo Weng
Article
Multidisciplinary Sciences
Buqing Ye, Benyu Liu, Lu Hao, Xiaoxiao Zhu, Liuliu Yang, Shuo Wang, Pengyan Xia, Ying Du, Shu Meng, Guanling Huang, Xiwen Qin, Yanying Wang, Xinlong Yan, Chong Li, Junfeng Hao, Pingping Zhu, Luyun He, Yong Tian, Zusen Fan
NATURE COMMUNICATIONS
(2018)
Article
Cell Biology
Ting Xie, Yizhou Wang, Nan Deng, Guanling Huang, Forough Taghavifar, Yan Geng, Ningshan Liu, Vrishika Kulur, Changfu Yao, Peter Chen, Zhengqiu Liu, Barry Stripp, Jie Tang, Jiurong Liang, Paul W. Noble, Dianhua Jiang
Article
Biochemistry & Molecular Biology
Jiurong Liang, Ningshan Liu, Xue Liu, Jessica Monterrosa Mena, Ting Xie, Yan Geng, Caijuan Huan, Yanli Zhang, Forough Taghavifar, Guanling Huang, Adrianne Kurkciyan, Vivian Barron, Dianhua Jiang, Paul W. Noble
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Article
Cell Biology
Pingping Zhu, Jiayi Wu, Yanying Wang, Xiaoxiao Zhu, Tiankun Lu, Benyu Liu, Luyun He, Buqing Ye, Shuo Wang, Shu Meng, Dongdong Fan, Jing Wang, Liuliu Yang, Xiwen Qin, Ying Du, Chong Li, Lei He, Weizheng Ren, Xin Wu, Yong Tian, Zusen Fan
NATURE CELL BIOLOGY
(2018)
Article
Immunology
Pingping Zhu, Xiaoxiao Zhu, Jiayi Wu, Luyun He, Tiankun Lu, Yanying Wang, Benyu Liu, Buqing Ye, Lei Sun, Dongdong Fan, Jing Wang, Liuliu Yang, Xiwen Qin, Ying Du, Chong Li, Lei He, Weizheng Ren, Xin Wu, Yong Tian, Zusen Fan
Article
Biochemistry & Molecular Biology
Ziyang Hao, Tong Wu, Xiaolong Cui, Pingping Zhu, Caiping Tan, Xiaoyang Dou, Kai-Wen Hsu, Yueh-Te Lin, Pei-Hua Peng, Li-Sheng Zhang, Yawei Gao, Lulu Hu, Hui-Lung Sun, Allen Zhu, Jianzhao Liu, Kou-Juey Wu, Chuan He
Article
Critical Care Medicine
Changfu Yao, Xiangrong Guan, Gianni Carraro, Tanyalak Parimon, Xue Liu, Guanling Huang, Apoorva Mulay, Harmik J. Soukiasian, Gregory David, Stephen S. Weigt, John A. Belperio, Peter Chen, Dianhua Jiang, Paul W. Noble, Barry R. Stripp
Summary: The study demonstrates that senescence of AT2 cells is sufficient to drive progressive pulmonary fibrosis, and interventions targeting p53 activation or senescence can block fibrogenesis. Early attenuation of senescence-related pathways and elimination of senescent cells are promising therapeutic approaches to prevent pulmonary fibrosis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Miriam S. Hohmann, David M. Habiel, Milena S. Espindola, Guanling Huang, Isabelle Jones, Rohan Narayanan, Ana Lucia Coelho, Justin M. Oldham, Imre Noth, Shwu-Fan Ma, Adrianne Kurkciyan, Jonathan L. McQualter, Gianni Carraro, Barry Stripp, Peter Chen, Dianhua Jiang, Paul W. Noble, William Parks, John Woronicz, Geoffrey Yarranton, Lynne A. Murray, Cory M. Hogaboam
Summary: IPF is characterized by elevated levels of CCR10 and CCL28 in lung tissue, with CCR10(+) cells promoting pulmonary fibrosis and EphA3 mAb targeting these cells reducing fibrosis.
Article
Multidisciplinary Sciences
Xue Liu, Simon C. Rowan, Jiurong Liang, Changfu Yao, Guanling Huang, Nan Deng, Ting Xie, Di Wu, Yizhou Wang, Ankita Burman, Tanyalak Parimon, Zea Borok, Peter Chen, William C. Parks, Cory M. Hogaboam, S. Samuel Weigt, John Belperio, Barry R. Stripp, Paul W. Noble, Dianhua Jiang
Summary: Pulmonary mesenchymal cells play critical roles in lung development and disease states in both mice and humans, showing high heterogeneity and subtype-specific transcriptomic differences which contribute to matrix gene expression in fibrosis. Comparative analysis reveals conserved transcriptomic signatures in orthologous subpopulations of murine and human lung mesenchymal cells, enhancing our understanding of mesenchymal cell diversity in lung development and disease conditions.
Article
Multidisciplinary Sciences
Ting Xie, Vrishika Kulur, Ningshan Liu, Nan Deng, Yizhou Wang, Simon Coyle Rowan, Changfu Yao, Guanling Huang, Xue Liu, Forough Taghavifar, Jiurong Liang, Cory Hogaboam, Barry Stripp, Peter Chen, Dianhua Jiang, Paul W. Noble
Summary: Recent studies have shown that impaired renewal of type 2 alveolar epithelial cells (ATII) in IPF patients and mice with defective ATII can lead to severe pulmonary fibrosis. Growth hormone receptor (GHR) expression, mainly found in mesenchymal cells, is significantly decreased in IPF lungs, but higher levels of GHR expression are associated with better lung function in IPF patients. The findings suggest that a previously unidentified mesenchymal paracrine signaling via GHR can support ATII progenitor cell renewal and limit the severity of lung fibrosis.
Article
Medicine, Research & Experimental
Jiurong Liang, Guanling Huang, Xue Liu, Forough Taghavifar, Ningshan Liu, Yizhou Wang, Nan Deng, Changfu Yao, Ting Xie, Vrishika Kulur, Kristy Dai, Ankita Burman, Simon C. Rowan, S. Samuel Weigt, John Belperio, Barry Stripp, William C. Parks, Dianhua Jiang, Paul W. Noble
Summary: This study identified a deficiency of the zinc transporter SLC39A8 (ZIP8) in Type 2 alveolar epithelial cells (AEC2s) from both idiopathic pulmonary fibrosis (IPF) lungs and lungs of old mice, which is associated with impaired AEC2 renewal capacity and enhanced lung fibrosis. The regulation of AEC2 progenitor function by ZIP8 is dependent on SIRT1. Replenishment with exogenous zinc and activation of SIRT1 promote self-renewal and differentiation of AEC2s, and therapeutic strategies targeting zinc metabolism and SIRT1 signaling could potentially improve AEC2 progenitor function and mitigate fibrogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Yan Geng, Xue Liu, Jiurong Liang, David M. Habiel, Vrishika Kulur, Ana Lucia Coelho, Nan Deng, Ting Xie, Yizhou Wang, Ningshan Liu, Guanling Huang, Adrianne Kurkciyan, Zhenqiu Liu, Jie Tang, Cory M. Hogaboam, Dianhua Jiang, Paul W. Noble
Article
Oncology
Xinlong Yan, Dongdong Zhang, Wei Wu, Shuheng Wu, Jingfeng Qian, Yajing Hao, Fang Yan, Pingping Zhu, Jiayi Wu, Guanling Huang, Yinghui Huang, Jianjun Luo, Xinhui Liu, Benyu Liu, Xiaomin Chen, Ying Du, Runsheng Chen, Zusen Fan
