期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 23, 期 11, 页码 954-956出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3315
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资金
- NIGMS NIH HHS [R01 GM080465] Funding Source: Medline
The degradation of mRNAs involves removal of the 5' protective cap via a decapping-enzyme complex, in a largely irreversible process that commits the transcript for destruction. Understanding how the decapping reaction is catalyzed and regulated are major goals in the field. New data suggest how the chemistry of decapping is controlled and orchestrated within the cell.
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