Article
Biology
Antoine Beauchamp, Yohan Yee, Ben C. Darwin, Armin Raznahan, Rogier B. Mars, Jason P. Lerch
Summary: Researchers use a common reference space approach to evaluate the similarity between mouse and human brain, finding that mouse-human homologous genes can capture general patterns of neuroanatomical organization. By using a supervised machine learning approach, the resolution of cross-species correspondences can be improved.
Review
Materials Science, Multidisciplinary
Roya Nazempour, Bozhen Zhang, Zhongyin Ye, Lan Yin, Xianli Lv, Xing Sheng
Summary: Research in neuroscience and neuroengineering has seen a surge of interest in recent decades. Optical fiber based technologies offer a viable and versatile tool for studying the brain, with potential applications in clinical settings. The small size, flexibility, and light weight of optical fibers make them ideal for understanding complex behaviors in living mammals.
ADVANCED FIBER MATERIALS
(2022)
Article
Clinical Neurology
Aleksey N. Ikrin, Anastasia M. Moskalenko, Radmir R. Mukhamadeev, Murilo S. de Abreu, Tatiana O. Kolesnikova, Allan Kalueff
Summary: This study analyzed a dataset of 227 genes, whose mutations can cause abnormal self-grooming in mice. Through the construction of a protein-protein interaction network, several molecular clusters related to various cellular processes were identified. Further bioinformatics analyses revealed key hub proteins within these clusters, which may be implicated in aberrant self-grooming and repetitive behaviors. Understanding the complex molecular pathways of this important behavior contributes to the understanding and potential treatment of related neurological disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Review
Orthopedics
M. Alves-Simoes
Summary: This review provides an overview of current models used for studying osteoarthritis (OA) pain, focusing on mice and rats. The article emphasizes that although there is no ideal model for studying OA pain, increased efforts in phenotyping OA will impact the choice of models for pre-clinical and basic research studies.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Editorial Material
Multidisciplinary Sciences
Nikki Forrester
Summary: Researchers discuss the impact of listening to music on productivity at work and share the music that helps them stay focused.
Article
Construction & Building Technology
Li Xu, Jinlong Pan, Xiao Yang
Summary: This study investigated the mechanical performance of self-stressing CFST columns under uniaxial compression and proposed a calculation method. Experimental results showed that adding expansive agent significantly improved the load-bearing capacity of CFST columns, with the degree of improvement related to the initial self-stress.
JOURNAL OF BUILDING ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Koen M. M. Frolichs, Gabriela Rosenblau, Christoph W. Korn
Summary: In order to navigate social interactions successfully, humans need to continuously learn about the personality traits of other people. This study develops computational models that show how people learn about others' personalities, relying on prior beliefs and similarities between personality traits.
NATURE COMMUNICATIONS
(2022)
Article
Construction & Building Technology
He Zhu, Duo Zhang, Yichao Wang, Tianyu Wang, Victor C. Li
Summary: The objective of this research is to develop a self-stressing ECC, which can automatically induce pressure onto the repair material, by utilizing a combination of super absorbent polymer (SAP), shrinkage reducing agent (SRA), and calcium sulphoaluminate cement/expansive additive (CSA). The deliberate combination of SRA and CSA tailors the maximum expansion and expansion loss, enhancing the durability of ECC for infrastructure repair in aggressive environments.
CEMENT & CONCRETE COMPOSITES
(2021)
Article
Construction & Building Technology
He Zhu, Duo Zhang, Tianyu Wang, Morgan McBain, Victor C. Li
Summary: This research developed a low carbon self-stressing ECC using LC3 and CSA, which has a lower carbon footprint and similar embodied energy compared to conventional concrete, while also possessing durability, high ductility, and self-stressing functionality.
CEMENT AND CONCRETE RESEARCH
(2021)
Review
Multidisciplinary Sciences
Efthymios Papatzikis, Maria Agapaki, Rosari Naveena Selvan, Varun Pandey, Fathima Zeba
Summary: Research on how music influences brain plasticity has gained momentum, but nonuniform methodological standards have led to nonreplicable findings. To address this issue, a study appraised the methodological rigor of all 2019 studies in the field, aiming to establish a standardized baseline of research quality.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Ecology
Luis D. Verde Arregoitia, Guillermo D'Elia
Summary: The foods consumed by animals reflect their adaptations and ecological roles, which makes diet an important trait for ecological, evolutionary, and paleobiological research. Researchers need to use classification schemes that capture the intrinsic differences in diet composition.
Article
Multidisciplinary Sciences
Jinwen Xue, Dandan Qian, Bingqian Zhang, Jingxuan Yang, Wei Li, Yifei Bao, Shi Qiu, Yi Fu, Shaoli Wang, Ti-Fei Yuan, Wei Lu
Summary: The neurobiology of obsessive-compulsive disorder (OCD) involves dysregulation of frontostriatal circuitry and altered monoamine transmission. Dopamine (DA) neurons in the substantia nigra pars compacta (SNc) have been found to control self-grooming behavior through the ventromedial striatum (VMS) and lateral orbitofrontal cortex (lOFC) pathways. The activity of SNc-VMS pathway promotes grooming via D1 receptors, while the activity of SNc-lOFC pathway suppresses grooming via D2 receptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Construction & Building Technology
Boxin Wang, Ke Yuan, Xinyu Lu, Jianyu Zhao
Summary: Textile reinforced self-stressing concrete (TRSSC) has excellent cracking resistance, with the increase in the number of textile layers improving the cracking resistance of specimens. Self-stress can effectively increase the cracking load of specimens.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Editorial Material
Biology
Jane M. Carlton
Summary: The study of human malaria has been enhanced by the use of model systems like rodent malaria parasites. A recent paper has filled the gap in resources for Plasmodium vinckei, providing new datasets, experimental protocols, and phenotypes to propel this species into the 21st century.
Article
Neurosciences
Marie Levorsen, Ryuta Aoki, Kenji Matsumoto, Constantine Sedikides, Keise Izuma
Summary: Knowledge about one's personality, the self-concept, shapes human experience. Social cognitive neuroscience has made progress in understanding how the self is represented in the brain, but the answer remains elusive. Through two functional magnetic resonance imaging experiments, we found that the importance of attributes to self-identity is represented in the medial prefrontal cortex (mPFC), which is unrelated to the self-descriptiveness of attributes and importance of attributes to a friend's self-identity. Our research provides a comprehensive answer: The self-concept is conceptualized in terms of self-importance and represented in the mPFC.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Barbara D. Fontana, Talise E. Muller, Madeleine Cleal, Murilo S. de Abreu, William H. J. Norton, Konstantin A. Demin, Tamara G. Amstislavskaya, Elena Petersen, Allan Kalueff, Matthew O. Parker, Denis B. Rosemberg
Summary: Social behavior plays a crucial role in maintaining health and wellbeing, while dysfunctional interactions pose risks for physical and psychiatric disorders. Despite extensive research on the effects of positive and negative social interactions, the underlying mechanisms remain unclear. Zebrafish, with well-characterized social behavior phenotypes and genetic similarities to humans, offer a promising model for studying the fundamental mechanisms of social interactions.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Neurosciences
Fabiano Costa, Luiz Rosa, Vanessa A. Quadros, Murilo S. de Abreu, Adair R. S. Santos, Lynne U. Sneddon, Allan Kalueff, Denis B. Rosemberg
Summary: This article introduces the advantages of zebrafish as a pain model and its applications in studying the mechanisms of pain response. The article also discusses the latest research advances and outlines the potential advantages and limitations of zebrafish models in studying pain behaviors and mood disorders, as well as facilitating analgesic therapy screening.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Neurosciences
Murilo S. de Abreu, Fabiano Costa, Ana C. V. V. Giacomini, Konstantin A. Demin, Elena Petersen, Denis B. Rosemberg, Allan Kalueff
Summary: Although traditional medicine has been practiced for a long time, its therapeutic mechanisms are not fully understood. This study highlights the importance of using zebrafish as a model organism to study the neurotropic effects of traditional medicine and their potential in treating brain disorders.
CURRENT NEUROPHARMACOLOGY
(2022)
Editorial Material
Neurosciences
Brian A. Baldo, Kent C. Berridge
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Murilo S. de Abreu, Fabiano Costa, Ana C. V. V. Giacomini, Konstantin A. Demin, Konstantin N. Zabegalov, Gleb O. Maslov, Yuriy M. Kositsyn, Elena Petersen, Tatiana Strekalova, Denis B. Rosemberg, Allan Kalueff
Summary: Mood disorders, particularly depression, are a leading cause of disability in humans. Anhedonia, the loss of pleasure, is a common and severe symptom of clinical depression. Experimental animal models are used extensively to understand the mechanisms of depression and develop new treatments, with rodents being widely validated. Zebrafish, as a model organism, is emerging as a powerful tool for studying affective disorders and modeling anhedonia, offering potential for translational research.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Dmitrii Bozhko, Vladislav O. Myrov, Sofia M. Kolchanova, Aleksandr Polovian, Georgii K. Galumov, Konstantin A. Demin, Konstantin N. Zabegalov, Tatiana Strekalova, Murilo S. de Abreu, Elena Petersen, Allan Kalueff
Summary: This study utilized AI neural network algorithms to analyze zebrafish locomotor track data, providing novel methods for neurophenotypic data collection and analysis. By training AI to recognize different psychotropic drugs and confirming its accuracy, a framework for improving movement pattern classification in zebrafish was presented, in order to advance drug discovery and development using this model organism.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Cell Biology
Evgeniy Svirin, Ekaterina Veniaminova, Joao Pedro Costa-Nunes, Anna Gorlova, Aleksei Umriukhin, Allan Kalueff, Andrey Proshin, Daniel C. Anthony, Andrey Nedorubov, Anna Chung Kwan Tse, Susanne Walitza, Lee Wei Lim, Klaus-Peter Lesch, Tatyana Strekalova
Summary: The interaction between brain serotonin deficiency and environmental adversity leads to excessive aggression in females. Complete inactivation of the gene encoding tryptophan hydroxylase-2 results in the absence of neuronal serotonin synthesis and aggression in male and female mice. Moderate reduction in brain serotonin levels and exposure to stress also lead to increased aggression in male mice. Furthermore, changes in gene expression and myelination-related processes may underlie the molecular mechanisms of aggressive behavior.
Article
Pharmacology & Pharmacy
Maria A. Tikhonova, Nikolai A. Maslov, Alim A. Bashirzade, Eugenyi V. Nehoroshev, Vladislav Y. Babchenko, Nadezhda D. Chizhova, Elena O. Tsibulskaya, Anna A. Akopyan, Evgeniya V. Markova, Yi-Ling Yang, Kwok-Tung Lu, Allan V. Kalueff, Lyubomir I. Aftanas, Tamara G. Amstislavskaya
Summary: Researchers developed a laser-induced brain injury model in zebrafish, which successfully replicated behavioral and neuroanatomical changes observed in traumatic brain injury (TBI). The model showed similarities to mammalian TBI models, validating its effectiveness. The study also examined the changes in neurons and brain-derived neurotrophic factor (BDNF) after the injury, as well as the activation of microglia and the levels of hypoxia-inducible factor 1-alpha (Hif1a).
Review
Biochemistry & Molecular Biology
Evgeniy Svirin, Johannes de Munter, Aleksei Umriukhin, Elisaveta Sheveleva, Allan Kalueff, Andrei Svistunov, Sergey Morozov, Susanne Walitza, Tatyana Strekalova
Summary: Gangliosides play important roles in neural development and function, and their dysfunction is associated with neurological disorders and psychiatric conditions. Abnormal ganglioside function can result in neuroinflammation, aberrant myelination, and altered insulin receptor signaling. Understanding the role of gangliosides in developmental neuropsychiatric disorders is of great clinical significance.
Review
Biochemistry & Molecular Biology
Tatiana O. Kolesnikova, Konstantin A. Demin, Fabiano Costa, Konstantin N. Zabegalov, Murilo S. de Abreu, Elena Gerasimova, Allan Kalueff
Summary: Channelopathies are systemic disorders associated with dysfunctional ion channels. The zebrafish has become a popular model organism for studying these disorders, but there are still challenges to overcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ilya S. Zhukov, Inessa Karpova, Nataliya A. Krotova, Ilya Y. Tissen, Konstantin A. Demin, Petr D. Shabanov, Evgeny A. Budygin, Allan Kalueff, Raul R. Gainetdinov
Summary: The study characterizes the behavioral and neurochemical phenotypes of TAAR1 knockout mice, finding that these mice exhibit increased aggression in the resident-intruder test, reduced self-grooming behavior in the novelty-induced grooming test, and higher cortical serotonin levels. The findings suggest a potential association between TAAR1 and aggression-related neuropsychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Fabiano V. Costa, Tatiana O. Kolesnikova, David S. Galstyan, Nikita P. Ilyin, Murilo S. de Abreu, Elena V. Petersen, Konstantin A. Demin, Konstantin B. Yenkoyan, Allan V. Kalueff
Summary: Psychiatric disorders are prevalent brain pathologies. Reliable animal models are needed for effective treatment. Zebrafish show complex behaviors similar to rodents and humans, making them suitable for modeling psychiatric disorders. However, there are challenges and the field needs further discussion and consideration of clinical prevalence and pathological complexity. Recent developments in molecular biology might pave the way for wider use of zebrafish in CNS disease modeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anton D. D. Shevlyakov, Tatiana O. O. Kolesnikova, Murilo S. S. de Abreu, Elena V. V. Petersen, Konstantin B. B. Yenkoyan, Konstantin A. A. Demin, Allan V. V. Kalueff
Summary: Epilepsy is a neurological disorder characterized by seizures and neuronal hyperactivity. The exact pathogenesis is not fully understood, but genetic factors are known to play a key role. In this study, a computational approach was used to generate a comprehensive network of molecular pathways associated with epilepsy. The study identified potential key interactors and revealed functional molecular pathways, highlighting the importance of targeting downstream pathways for more effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Veterinary Sciences
Maria M. Kotova, David S. Galstyan, Tatiana O. Kolesnikova, Murilo S. de Abreu, Tamara G. Amstislavskaya, Tatyana Strekalova, Elena V. Petersen, Konstantin B. Yenkoyan, Konstantin A. Demin, Allan V. Kalueff
Summary: Antimicrobial drugs can influence the central nervous system and gut microbiota, leading to changes in brain and behavior. Zebrafish models are useful for studying the effects of these drugs on the central nervous system. Recent research has revealed the impacts of a wide range of antimicrobial drugs on brain and behavior in zebrafish.
VETERINARY SCIENCES
(2023)
Meeting Abstract
Neurosciences
Kent Berridge
BIOLOGICAL PSYCHIATRY
(2022)
