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Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal study

LIFE SCIENCE ALLIANCE (2023)

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LIFE SCIENCE ALLIANCE
卷 7, 期 1, 页码 -

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LIFE SCIENCE ALLIANCE LLC
DOI: 10.26508/lsa.202302305

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This study investigates the longitudinal changes in gene/transcript expression patterns in hospital-admitted severe COVID-19 patients with ARDS post-acute SARS-CoV-2 infection. The findings highlight the dynamic gene/transcript expression changes during ARDS progression, impact on tissue oxygenation, and elucidate the disease pathogenesis.
Understanding the dynamic changes in gene expression during acute infection patients is crucial for unraveling the underlying mechanisms. Study investigates the longitudinal changes in gene/ transcript expression patterns in hospital-admitted severe COVID19 patients with ARDS post-acute SARS-CoV-2 infection. Blood samples were collected at three time points and patients were stratified into severe and mild ARDS, based on their oxygenation saturation (SpO2/FiO2) kinetics over 7 d. Decline in transcript diversity was observed over time, particularly in patients with higher paring gene/transcript-level analyses highlighted a rather limited overlap. With disease progression, a transition towards an inflammatory state was evident. Strong association was found between antibody response and disease severity, characterized by decreased antibody response and activated B cell population in severe cases. Bayesian network analysis identified various factors associated with disease progression and severity, viz. humoral response, TLR signaling, inflammatory response, interferon response, and effector T cell abundance. The findings highlight dynamic gene/transcript expression changes during ARDS progression, impact on tissue oxygenation and elucidate disease pathogenesis.

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