Article
Biology
Joseph L. Ransdell, Jonathan D. Moreno, Druv Bhagavan, Jonathan R. Silva, Jeanne M. Nerbonne
Summary: The resurgent component of the voltage-gated sodium current (I-NaR) is a depolarizing conductance that regulates the firing properties of various neuronal cell types. The mechanism behind the generation of I-NaR, mediated by voltage-gated sodium channels, remains unclear. This study provides evidence that resurgent Na+ influx occurs as a result of fast inactivating Nav channels transitioning into an open/conducting state on membrane hyperpolarization, and the decay of I-NaR reflects the slow accumulation of recovered/opened Nav channels into a second inactivated state. The amplitude of I-NaR can be modulated by factors such as the accessory Nav beta 4 channel subunit.
Article
Neurosciences
Zhaoyang Li, Wenhao Dong, Xinyuan Zhang, Jun-Mei Lu, Yan-Ai Mei, Changlong Hu
Summary: The study demonstrates that PKC activation inhibits Kv2.2 channel currents and alters their steady-state activation, showing that the function of Kv2.2 is dependent on its phosphorylation state. In cortical slices, PKC activation reduces the frequency of action potentials by regulating Kv2.2 channels.
NEUROSCIENCE BULLETIN
(2022)
Article
Medicine, Research & Experimental
Yunmei Zhang, Yuan Zhang, Zizhang Wang, Yufang Sun, Xinghong Jiang, Man Xue, Yafeng Yu, Jin Tao
Summary: This study reveals that gentamicin decreases the I-DR in VG neurons through JNK and PKA-mediated signaling pathways, leading to neuronal hyperexcitability. Blocking JNK signaling and I-DR can attenuate this effect.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Ernesto Griego, Melissa Hernandez-Frausto, Luis A. Marquez, Leonardo Lara-Valderrabano, Carolina Lopez Rubalcava, Emilio J. Galvan
Summary: The study identifies electrophysiologic alterations in animals treated with MK-801, including up-regulation of ionic currents and reduced excitability, which may contribute to cognitive symptoms of schizophrenia. Additionally, the study demonstrates reduced cognitive performance in animals treated with MK-801.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Ryan P. D. Alexander, Derek Bowie
Summary: NMDA receptors induce long-term changes in firing rates of inhibitory stellate cells by driving intrinsic plasticity through a Ca2+- and CaMKII-dependent pathway, which alters the activation and inactivation properties of voltage-gated Na+ channels. This signaling pathway also lowers the action potential threshold by causing a hyperpolarizing shift in Na+ channel gating, suggesting a potential mechanism for fine-tuning motor behavior.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Jaegeon Lee, Seung Ha Kim, Dong Cheol Jang, Mirae Jang, Myeong Seong Bak, Hyun Geun Shim, Yong-Seok Lee, Sang Jeong Kim
Summary: Plasticity, both synaptic and intrinsic, is crucial for learning and memory. Abnormalities in homeostatic plasticity can lead to neuropsychiatric diseases such as schizophrenia and autism. The balance between synaptic transmission and intrinsic excitability is important for physiological function in the brain. In this study, the relationship between synaptic and intrinsic plasticity in fear memory was explored, and it was found that intrinsic plasticity in Purkinje cells plays a novel role in fear memory.
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Zeng-Xin Qi, Kang-Li Shen, Jian-Ya Peng, Xiu-Juan Fan, Hui-Wei Huang, Jian-Lan Jiang, Jian-Hua Lu, Xiao-Qin Wang, Xiao-Xia Fang, Liang Chen, Qian-Xing Zhuang
Summary: Histamine has a significant effect on LGP(PV) neurons and motor behavior, increasing the intrinsic excitability of LGP(PV) neurons. This may suggest a potential role of histamine in motor deficits, such as Parkinson's disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Larry W. Swanson, Joel D. Hahn, Olaf Sporns
Summary: The study used network science tools to reveal the global organizing principles of intramidbrain axonal circuitry, dividing it into multiple subsystems. These subsystems play specific roles in sensory-motor mechanisms, motivation and reward, regulating complex reproductive and agonistic behaviors, and behavioral state control, providing a theoretical framework for studying the neural circuit mechanisms underlying behavioral responses mediated by the midbrain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Xin Li, Hongyu Zhong, Zhongke Wang, Rui Xiao, Per Antonson, Tianyao Liu, Chuan Wu, Jiao Zou, Lian Wang, Ivan Nalvarte, Haiwei Xu, Margaret Warner, Jan-Ake Gustafsson, Xiaotang Fan
Summary: Astrocytic LXR beta in the medial prefrontal cortex plays a critical role in regulating synaptic transmission and its deletion may lead to anxiety-like behavior. Normalizing synaptic transmission in layer V pyramidal neurons of the mPFC can alleviate anxiety symptoms.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Shane M. Ohline, Xinhuai Liu, Mohamed F. Ibrahim, Bruce M. Mockett, Ruth M. Empson, Wickliffe C. Abraham, Karl J. Iremonger, Peter P. Jones
Summary: This study compared intrinsic excitability and spontaneous synaptic inputs in CA1 hippocampal neurons of aged APPswe/PS1dE9 mice and wildtype control mice. The results showed no change in intrinsic excitability or spontaneous postsynaptic currents between the two groups, but a reduced input resistance and an increase in hyperpolarization-activated sag current were observed. These findings suggest that neuronal hyperexcitability may not be a consistent feature of all AD mouse models.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Lulu Yao, Yi Rong, Xiaoyan Ma, Haifu Li, Di Deng, Yongjun Chen, Sungchil Yang, Tao Peng, Tao Ye, Feixue Liang, Nenggui Xu, Qiang Zhou
Summary: NMDA subtype glutamate receptors play bidirectional roles in modulating the intrinsic excitability of inhibitory GABAergic neurons, depending on the subunit composition of NMDARs. These findings highlight the importance of NMDARs in inhibitory neurons and contribute to a better understanding of brain diseases.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Guillermo Gonzalez-Burgos, Takeaki Miyamae, Nita Reddy, Sidney Dawkins, Chloe Chen, Avyi Hill, John Enwright, Bard Ermentrout, David A. Lewis
Summary: In primates, the DLPFC and PPC cortices play crucial roles in the working memory network, with higher frequency oscillations observed in DLPFC. The higher frequency in DLPFC may be attributed to a greater quantity of synapses in the basal dendrites, leading to stronger synaptically evoked excitation and subsequently, increased oscillation frequency and power. These findings provide insights into the mechanisms underlying regional differences in oscillation properties between brain regions.
Article
Neurosciences
Yi Cheng, Nan Song, Renkai Ge, Yue Dai
Summary: In this study, the biophysical and modulatory properties of persistent inward currents (PICs) in serotonergic neurons in the medulla were investigated using patch-clamp technique. The study revealed that different components of PICs contribute to the upregulation of excitability in these neurons, and serotonin enhances this effect, leading to facilitated repetitive firing in serotonergic neurons. The findings shed light on the channel mechanisms responsible for serotonergic modulation of serotonergic neurons in the brainstem.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Biochemistry & Molecular Biology
Elisabetta Coppi, Federica Cherchi, Erica Sarchielli, Irene Fusco, Giulia Guarnieri, Pasquale Gallina, Renato Corradetti, Felicita Pedata, Gabriella B. Vannelli, Anna Maria Pugliese, Annamaria Morelli
Summary: This study characterized cholinergic effects in human NBM neurons, showing that acetylcholine can modulate ion channels by enhancing K currents, reducing Na currents, and activating different receptors. Spontaneous acetylcholine release from neuroblasts in the human fetal NBM may play a key role in brain development.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
He Liu, Ashutosh Rastogi, Priyam Narain, Qing Xu, Merima Sabanovic, Ayesha Darwish Alhammadi, Lihua Guo, Jun-Li Cao, Hongxing Zhang, Hala Aqel, Vongai Mlambo, Rachid Rezgui, Basma Radwan, Dipesh Chaudhury
Summary: The disruption of daily rhythms in patients with mood disorders may be attributed to the dysfunction of the lateral habenula and dorsal raphe nucleus. Stress-susceptibility in mice is associated with decreased firing rates in cells projecting from LHb to DRN, while stress-resilient mice show maintained daily rhythms in firing. This correlation between activity in this neural circuit and mood disorders highlights the importance of circadian timekeeping in regulating emotional well-being.