Article
Multidisciplinary Sciences
Laure Alexandre-Heymann, Marie Puerto, Clemence Martin, Esperie Burnet, Helen Mosnier-Pudar, Pierre-Regis Burgel, Etienne Larger
Summary: Pancreatic imaging is usually abnormal in subjects with CFRD, while it is normal in approximately one third of CF control subjects. Pancreatic calcification is a specific feature observed in subjects with CFRD.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Madina Makhmutova, Alejandro Caicedo
Summary: Pancreatic innervation is a complex field that benefits from advances in technology for more precise study of neuronal activity. However, the specific role of pancreatic innervation in organ physiology and pathophysiology is still not fully understood.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei-Xia Li, Fei Miao, Xue-Qin Xu, Jing Zhang, Zhi-Yuan Wu, Ke-Min Chen, Fu-Hua Yan, Xiao-Zhu Lin
Summary: There are significant differences in CT spectral imaging parameters between non-LG and LG PNENs. Tumor size is the most promising independent parameter, and the combination of quantitative parameters with qualitative parameters is the best predictor in differentiating non-LG PNENs from LG PNENs. CT spectral imaging can help determine the malignancy of PNENs and assist in surgical planning.
ACADEMIC RADIOLOGY
(2021)
Review
Endocrinology & Metabolism
Dian R. Arifin, Jeff W. M. Bulte
Summary: Pancreatic islet transplantation has the potential to provide life-long blood glucose management for diabetic patients, with imaging technology playing a crucial role in monitoring and evaluating the success of cell implants in vivo. Various imaging modalities are being developed to improve the precision and efficacy of islet therapy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Danuta Liberda, Paulina Koziol, Tomasz P. Wrobel
Summary: Infrared (IR) based histopathology is a valuable tool for studying tissues and has potential clinical applications. This study develops a robust machine learning model for pancreatic cancer detection using IR imaging. By analyzing a large dataset of over 600 biopsies, this model achieved high accuracy in classifying pancreatic cancer at a pixel level, demonstrating successful digital staining with biochemical information extracted from IR spectra.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Medicine, Research & Experimental
Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chung Ying Chan, Zijun Chen, Gianluca Destro, Mathew Veal, Doreen Lau, Edward O'Neill, Gemma Dias, Michael Mosley, Veerle Kersemans, Florian Guibbal, Veronique Gouverneur, Bart Cornelissen
Summary: In this study, [F-18]rucaparib, a non-invasive PARP-targeting imaging agent, was developed for PET imaging of pancreatic cancer. The results showed its potential application value.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Acoustics
Vinh T. Pham, M. A. R. K. Ciccaglione, David G. Ramirez, Richard K. P. Benninger
Summary: The researchers previously found that measurements of pancreas perfusion dynamics can predict disease progression in type 1 diabetes (T1D). Now they tested whether these measurements can predict the success of therapeutic prevention of T1D.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Qian Zhao, Aisheng Dong, Tianlin He, Changjing Zuo
Summary: Somatostatin receptor PET imaging findings in 3 cases of diffuse pancreatic neuroendocrine tumor are presented. One case showed diffuse swelling and diffusely intense activity of the pancreas with multiple metastases. The other 2 cases showed diffusely intense activity of the pancreas without metastasis. The pancreatic tumor extended into the duodenum in all 3 cases. Familiarity with this rare pattern of radiotracer uptake may aid in diagnosis of pancreatic neuroendocrine tumor.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Taha M. Ahmed, Satomi Kawamoto, Ralph H. Hruban, Elliot K. Fishman, Philippe Soyer, Linda C. Chu
Summary: Artificial Intelligence (AI) is transforming medical imaging by utilizing the abundant data in medical images. The two main AI methods currently applied in radiology are deep learning and radiomics. Deep learning uses self-correcting algorithms to develop a mathematical model that best fits the data, while radiomics converts imaging data into mineable features. Both methods have the potential to enhance disease detection, characterization, and prognostication. This article reviews the current state of AI in pancreatic imaging and evaluates the quality of existing evidence using the radiomics quality score. © 2023 Societe francaise de radiologie. Published by Elsevier Masson SAS. All rights reserved.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Article
Medicine, Research & Experimental
Chenyi Liang, Wei Huang, You Zhang, Di Zhang, Shuxian An, Qianyun Wu, Haitao Zhao, Cheng Wang, Gang Huang, Weijun Wei, Jianjun Liu
Summary: This study aimed to evaluate the diagnostic value of novel immunoPET tracers targeting CD47 in preclinical pancreatic cancer models. The results showed that these tracers can effectively annotate the expression of CD47 and diagnose pancreatic cancer in a target-specific manner. The findings have implications for patient selection for CD47-targeted therapies and assessment of treatment response.
MOLECULAR PHARMACEUTICS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Giovanni Morana, Pierluigi Cie, Silvia Venturini
Summary: Cystic pancreatic lesions are often incidentally discovered during radiological examinations for unrelated symptoms. Radiologists play a crucial role in diagnosing and managing these lesions by correctly characterizing them through imaging and considering factors such as age, sex, and medical history for differential diagnosis. Other techniques such as endoscopic ultrasound may be needed for a final diagnosis, and multidisciplinary management is important for proper treatment.
INSIGHTS INTO IMAGING
(2021)
Article
Gastroenterology & Hepatology
Kosuke Minaga, Masayuki Kitano, Atsushi Nakai, Shunsuke Omoto, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Masakatsu Tsurusaki, Takaaki Chikugo, Ippei Matsumoto, Yasutaka Chiba, Tomohiro Watanabe, Masatoshi Kudo
Summary: CH-EUS-based Kupffer-phase imaging improves the detection rate of left liver lobe metastasis from pancreatic cancer and plays a crucial role in clinical decision-making. Its sensitivity for detecting small liver metastasis is significantly higher than CE-CT or FB-EUS.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Engineering, Biomedical
Elnaz Sheikh, Kirti Agrawal, Sanjit Roy, David Burk, Fabrizio Donnarumma, Young H. Ko, Praveen Kumar Guttula, Nrusingh C. Biswal, Hem D. Shukla, Manas Ranjan Gartia
Summary: This study demonstrates the simultaneous profiling of three protein biomarkers using SERS nanotags and antibody-functionalized nanoparticles in a syngeneic mouse model of pancreatic cancer. The multimodal imaging techniques used provide comprehensive information about biomarkers and TAM alterations before and after treatment. The study reveals the efficacy of 3-BP in treating pancreatic cancer and identifies drug treatment-induced lipid species remodeling and associated pathways through bioinformatics analysis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Cell Biology
Jingbo Li, Xin Chen, Rui Kang, Herbert Zeh, Daniel J. Klionsky, Daolin Tang
Summary: Autophagy is a degradation system that can remove abnormal proteins and damaged organelles, with impaired autophagy being a pathological feature of diseases like pancreatic cancer. Dysfunctional autophagy plays a complex role in pancreatic tumor biology, with targeting selective autophagy potentially reducing side effects of drugs.
Review
Oncology
Julien Dimastromatteo, Jacob L. Houghton, Jason S. Lewis, Kimberly A. Kelly
Article
Cardiac & Cardiovascular Systems
Julien Dimastromatteo, Laurent M. Riou, Mitra Ahmadi, Guillaume Pons, Eric Pellegrini, Alexis Broisat, Lucie Sancey, Tatiana Gavrilina, Didier Boturyn, Pascal Dumy, Daniel Fagret, Catherine Ghezzi
JOURNAL OF NUCLEAR CARDIOLOGY
(2010)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julien Dimastromatteo, Alexis Broisat, Pascale Perret, Mitra Ahmadi, Didier Boturyn, Pascal Dumy, Daniel Fagret, Laurent M. Riou, Catherine Ghezzi
JOURNAL OF NUCLEAR MEDICINE
(2013)
Meeting Abstract
Cardiac & Cardiovascular Systems
Alexis Broisat, Mirta Ruiz, Norman C. Goodman, Julien Dimastromatteo, David K. Glover
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2011)
Article
Physiology
Eric J. Charles, Mahendra D. Chordia, Yunge Zhao, Yi Zhang, J. Hunter Mehaffey, David K. Glover, Julien Dimastromatteo, W. Zachary Chancellor, Ashish K. Sharma, Irving L. Kron, Dongfeng Pan, Victor E. Laubach
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Samantha M. Perez, Julien Dimastromatteo, Charles N. Landen, Kimberly A. Kelly
Summary: The novel CSP-targeting monoclonal antibody 1H11 demonstrated potent anticancer activity against ovarian cancer by inducing significant and selective cytotoxicity, cell cycle arrest, and inhibiting cell migration. In vivo studies showed tumor growth inhibition, tumor necrosis, and increased sensitivity to chemotherapy.
Review
Oncology
Victoria A. Remley, Joel Linden, Todd W. Bauer, Julien Dimastromatteo
Summary: Tumors survive by suppressing antitumor immunity through the tumor microenvironment (TME). Checkpoint inhibitors like anti-PD-1 and anti-CTLA extend the survival of some cancer patients. Adenosine in the TME plays a key role in immunosuppression. Reducing adenosine production or blocking its receptors can enhance antitumor immunity.
CANCER DRUG RESISTANCE
(2023)
Review
Oncology
Lukasz A. Myc, Yun M. Shim, Victor E. Laubach, Julien Dimastromatteo
CLINICAL AND TRANSLATIONAL MEDICINE
(2019)
Review
Respiratory System
Julien Dimastromatteo, Eric J. Charles, Victor E. Laubach
RESPIRATORY RESEARCH
(2018)
Article
Cardiac & Cardiovascular Systems
Dror Luger, Michael J. Lipinski, Peter C. Westman, David K. Glover, Julien Dimastromatteo, Juan C. Frias, M. Teresa Albelda, Sergey Sikora, Alex Kharazi, Grigory Vertelov, Ron Waksman, Stephen E. Epstein
CIRCULATION RESEARCH
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Lipinski, D. Luger, P. C. Westman, D. K. Glover, J. Dimastromatteo, J. C. Frias, M. T. Albelda, S. Sikora, R. Waksman, S. E. Epstein
EUROPEAN HEART JOURNAL
(2016)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Julien Dimastromatteo, Kimberly Kelly, Stephanie Thomas, Alexander Klibanov, David Glover
JOURNAL OF NUCLEAR MEDICINE
(2012)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
J. Dimastromatteo, K. A. Kelly, S. Thomas, A. Klibanov, D. K. Glover
JOURNAL OF NUCLEAR MEDICINE
(2012)
Article
Physiology
S. Besse, F. Boucher, G. Linguet, L. Riou, J. de Leiris, B. Riou, J. Dimastromatteo, R. Comte, J. Courty, J. Delbe
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2010)