Impact of islet architecture on β-cell heterogeneity, plasticity and function

Targeting insulin-producing beta cells for regenerative therapy

(2016) Adriana Migliorini et al.   DIABETOLOGIA

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Stem cells versus plasticity in liver and pancreas regeneration

(2016) Janel L. Kopp et al.   NATURE CELL BIOLOGY

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Insulin-positive, Glut2-low cells present within mouse pancreas exhibit lineage plasticity and are enriched within extra-islet endocrine cell clusters

(2016) Christine A. Beamish et al.   Islets

Cadherins in Islet β-Cells: More Than Meets the Eye: Figure 1

(2015) Vincenzo Cirulli   DIABETES

Neurotransmitters and Neuropeptides: New Players in the Control of Islet of Langerhans' Cell Mass and Function

(2015) Eliana S. Di Cairano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human Islet Morphology Revisited

(2015) Susan Bonner-Weir et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Involvement of RhoA/ROCK in insulin secretion of pancreatic β-cells in 3D culture

(2014) Xiaofang Liu et al.   CELL AND TISSUE RESEARCH

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Vascular heterogeneity between native rat pancreatic islets is responsible for differences in survival and revascularisation post transplantation

(2014) Sara Ullsten et al.   DIABETOLOGIA

LKB1 and AMPK differentially regulate pancreatic β-cell identity

(2014) Marina Kone et al.   FASEB JOURNAL

Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology

(2014) Anja Marciniak et al.   Nature Protocols

Flattop regulates basal body docking and positioning in mono- and multiciliated cells

(2014) Moritz Gegg et al.   eLife

Islet cell plasticity and regeneration

(2014) Adriana Migliorini et al.   Molecular Metabolism

Making β Cells from Adult Cells Within the Pancreas

(2013) Philippe A. Lysy et al.   Current Diabetes Reports

The  -Cell/EC Axis: How Do Islet Cells Talk to Each Other?

(2013) H. Peiris et al.   DIABETES

Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin

(2013) N. Wakae-Takada et al.   DIABETOLOGIA

Topologically Heterogeneous Beta Cell Adaptation in Response to High-Fat Diet in Mice

(2013) Johanne H. Ellenbroek et al.   PLoS One

Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes

(2013) Xiaojun Wang et al.   PLoS One

Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation

(2013) Philip Borden et al.   Cell Reports

Three-Dimensional Analysis of the Islet Vasculature

(2012) Y. El-Gohary et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Superior beta cell proliferation, function and gene expression in a subpopulation of rat islets identified by high blood perfusion

(2012) J. Lau et al.   DIABETOLOGIA

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

(2012) P. Marchetti et al.   DIABETOLOGIA

Subpopulations of GFP-Marked Mouse Pancreatic β-Cells Differ in Size, Granularity, and Insulin Secretion

(2012) Hitoshi Katsuta et al.   ENDOCRINOLOGY

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

(2012) Cedric Cortijo et al.   Cell Reports

Planar Cell Polarity and the Developmental Control of Cell Behavior in Vertebrate Embryos

(2011) John B. Wallingford   Annual Review of Cell and Developmental Biology

Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas

(2011) Rayner Rodriguez-Diaz et al.   Cell Metabolism

The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin

(2011) Simon R. Smukler et al.   Cell Stem Cell

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells

(2011) R. Olsson et al.   DIABETES

FltpT2AiCre: A new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues

(2011) Anika Lange et al.   DIFFERENTIATION

Distinct expression patterns of dickkopf genes during late embryonic development of Danio rerio

(2011) Gerold Untergasser et al.   GENE EXPRESSION PATTERNS

Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes

(2011) German Kilimnik et al.   PLoS One

The islet-acinar axis of the pancreas: more than just insulin

(2010) Savio G. Barreto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The FoxA factors in organogenesis and differentiation

(2010) Klaus H Kaestner   CURRENT OPINION IN GENETICS & DEVELOPMENT

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

 -Cell Growth and Regeneration: Replication Is Only Part of the Story

(2010) S. Bonner-Weir et al.   DIABETES

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function

(2009) Zvi Granot et al.   Cell Metabolism

Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo

(2009) I. Burtscher et al.   DEVELOPMENT

Cell-cell interactions in the endocrine pancreas

(2009) R. Jain et al.   DIABETES OBESITY & METABOLISM

Single pancreatic beta cells co-express multiple islet hormone genes in mice

(2009) H. Katsuta et al.   DIABETOLOGIA

Exploring Functional β-Cell Heterogeneity In Vivo Using PSA-NCAM as a Specific Marker

(2009) Melis Karaca et al.   PLoS One

Enhanced β-cell mass without increased proliferation following chronic mild glucose infusion

(2008) Thomas L. Jetton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives

(2008) Owen J Tamplin et al.   BMC GENOMICS

PANIC-ATTAC: A Mouse Model for Inducible and Reversible  -Cell Ablation

(2008) Z. V. Wang et al.   DIABETES

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

(2008) A. Wojtusciszyn et al.   DIABETOLOGIA

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression

(2008) Véronique Serre-Beinier et al.   HUMAN MOLECULAR GENETICS

Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets

(2008) Lara R. Nyman et al.   JOURNAL OF CLINICAL INVESTIGATION

Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas

(2008) Yoshifumi Saisho et al.   JOURNAL OF MOLECULAR HISTOLOGY