Article
Immunology
Qi Lv, Yao Xing, Dong Dong, Yang Hu, Qingzhu Chen, Linhui Zhai, Lihong Hu, Yinan Zhang
Summary: Costunolide, a main active component of Radix Aucklandiae, demonstrated significant anti-inflammatory and immunomodulation effects in the study, by rebalancing Th17/Treg cells and reducing the levels of proinflammatory cytokines. The mechanism involved the inhibition of HIF-1 alpha-mediated glycolysis specifically in Th17 cells, which could potentially provide a new perspective on immune-metabolism therapy for colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Junhui Chen, Chunlei Zhang, Tengfeng Yan, Lixiang Yang, Yuhai Wang, Zhonghua Shi, Mingchang Li, Qianxue Chen
Summary: Atorvastatin treatment improved neurological outcomes in rats by inhibiting neural pyroptosis and neuroinflammation, reducing neuron death and increasing survival rate and neurological scores following SAH.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Jun Zou, Jaewon Yang, Xiaoye Zhu, Jianyong Zhong, Ahmed Elshaer, Taiji Matsusaka, Ira Pastan, Volker H. Haase, Hai-Chun Yang, Agnes B. Fogo
Summary: The study found that stabilizing hypoxia-inducible factor-alpha (HIF-alpha) can ameliorate tubulointerstitial injury and reduce its impact on subsequent glomerular injury. Restoring HIFs may blunt the adverse crosstalk between tubular injury and glomerular injury.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Yumeng Zhang, Wenhan Lu, Xiaoxue Li, Yu Wang, Lin Li, Yifan Dai, Haiyuan Yang, Ying Wang
Summary: This study found that n-3 polyunsaturated fatty acids (n-3 PUFAs) can reduce the incidence of cachexia after hypoxic-ischemic brain damage (HIBD) and improve factors related to cachexia. By reducing inflammation and oxidative stress, n-3 PUFAs help alleviate HPA axis hyperactivation and improve metabolic imbalance.
Article
Pharmacology & Pharmacy
Xiang-Sheng Zhang, Yue Lu, Wen Li, Tao Tao, Lei Peng, Wei-Han Wang, Sen Gao, Cang Liu, Zong Zhuang, Da-Yong Xia, Chun-Hua Hang, Wei Li
Summary: The study showed that astaxanthin significantly reduced oxidative stress and neuronal apoptosis after traumatic brain injury. Astaxanthin improved neurological functions through the SIRT1/Nrf2/Prx2/ASK1/p38 signaling pathway, suggesting it as a potential candidate for alleviating traumatic brain injury.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiromu Monai, Shinnosuke Koketsu, Yoshiaki Shinohara, Takatoshi Ueki, Peter Kusk, Natalie L. Hauglund, Andrew J. Samson, Maiken Nedergaard, Hajime Hirase
Summary: The use of AdR antagonists has been shown to decrease the recurrence of CSD waves, accelerate neural activity recovery, and reduce aberrant activity in astrocytes.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Stephen A. Tapanes, Dena Arizanovska, Madelen M. Diaz, Oluwarotimi O. Folorunso, Theresa Harvey, Stephanie E. Brown, Inna Radzishevsky, Liesl N. Close, Jonathan R. Jagid, Joacir Graciolli Cordeiro, Herman Wolosker, Darrick T. Balu, Daniel J. Liebl
Summary: Synaptic damage is a common response to traumatic CNS injury and contributes to cognitive dysfunction. In this study, researchers discovered that D-serine synthesized by reactive glial cells plays a crucial role in synaptic damage after traumatic brain injury (TBI). They also identified the potential therapeutic effect of inhibiting glial D-serine release through the transporter Slc1a4 (ASCT1). The study suggests a new role for glial D-serine in acute pathological dysfunction following brain trauma.
Review
Oncology
Ilias Mylonis, Georgia Chachami, George Simos
Summary: Hypoxia inducible transcription factors (HIFs) play a critical role in enabling cancer cells to thrive in low oxygen conditions. Inhibiting HIFs can prevent cancer cell growth and metastasis, with peptide HIF inhibitors showing potential as highly selective therapeutic agents. This review highlights the importance of targeting HIFs in cancer treatment and the promising development of peptide inhibitors.
Article
Biochemistry & Molecular Biology
Yuan Gao, Tao Wang, Ying Cheng, Yumin Wu, Luwen Zhu, Zhiya Gu, Youzhuang Wu, Luwei Cai, Yimin Wu, Yidan Zhang, Cheng Gao, Lili Li, Jing Li, Qianqian Li, Zufeng Wang, Ying Wang, Fudi Wang, Chengliang Luo, Luyang Tao
Summary: TBI is a common cause of death and disability, but there is a lack of effective drugs. The study shows that post-TBI, genes Mt1, Mt2, Il33, and Fth1 are upregulated and enriched in pathways associated with inflammation, oxidative phosphorylation, and ferroptosis. Melatonin confers neuroprotective effects by inhibiting inflammation and ferroptosis mainly through the MT2/IL-33 pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Heming Cheng, Yingbei Qi, Nanxi Lai, Lin Yang, Cenglin Xu, Shuang Wang, Yi Guo, Zhong Chen, Yi Wang
Summary: Inhibition of hyperactivity of DR 5-HTergic neuron may present promising anti-seizure effect, and DR may be a potential DBS target for the therapy of TLE.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell Biology
Julio Aguado, Harman K. Chaggar, Cecilia Gomez-Inclan, Mohammed R. Shaker, Hannah C. Leeson, Alan Mackay-Sim, Ernst J. Wolvetang
Summary: Ataxia-telangiectasia (A-T) is a genetic disorder caused by the lack of functional ATM kinase, leading to chronic inflammation and premature aging in the central nervous system. The cGAS-STING pathway is shown to play a crucial role in recognizing micronuclei and inducing senescence-associated secretory phenotype (SASP) in A-T cells and brain organoids, making it a novel therapeutic target for treating neuropathology in A-T patients.
Article
Medicine, General & Internal
You-Peng Zhang, Qin Yang, Yi-Ai Li, Ming-Huan Yu, Guo-Wei He, Yu-Xiang Zhu, Zhi-Gang Liu, Xiao-Cheng Liu
Summary: This study investigates the role of endoplasmic reticulum stress in deep hypothermic circulatory arrest (DHCA)-induced brain injury in rats and shows that inhibition of endoplasmic reticulum stress can alleviate brain injury, increase cell viability, and decrease apoptosis in DHCA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Xue-gong Fan, Si-ya Pei, Dan Zhou, Peng-cheng Zhou, Yan Huang, Xing-wang Hu, Teng Li, Yang Wang, Ze-bing Huang, Ning Li
Summary: Melittin, a major peptide component of bee venom, shows promising therapeutic effects for acute liver failure (ALF) by targeting PKM2 to inhibit inflammation through suppressing aerobic glycolysis in macrophages.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Agriculture, Multidisciplinary
Yujie Yao, Wenjing Zhu, Dongxu Han, Xu Shi, Shiwen Xu
Summary: This study demonstrated that melatonin (MT) can protect against BPA-induced colon damage by suppressing NOX-derived ROS, promoting DNA repair, and attenuating cell cycle arrest. These findings have important implications for understanding and preventing the detrimental effects of BPA on intestinal health.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yujie Yao, Wenjing Zhu, Dongxu Han, Xu Shi, Shiwen Xu
Summary: In this study, it was found that melatonin (MT) can alleviate the damage caused by bisphenol A (BPA) to the colon and further attenuate the G2/M cell cycle arrest by scavenging reactive oxygen species (ROS) produced by NADPH oxidase (NOX). The research revealed that MT improves DNA damage and the activation of related signaling pathways by regulating NOX, thus protecting intestinal health and preventing BPA-induced damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)