标题
Genome editing in cardiovascular diseases
作者
关键词
-
出版物
Nature Reviews Cardiology
Volume 14, Issue 1, Pages 11-20
出版商
Springer Nature
发表日期
2016-09-09
DOI
10.1038/nrcardio.2016.139
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- CRISPR-Cas9 Targeting ofPCSK9in Human Hepatocytes In Vivo—Brief ReportSignificance
- (2016) Xiao Wang et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- ApoE knockout rabbits: A novel model for the study of human hyperlipidemia
- (2016) Manabu Niimi et al. ATHEROSCLEROSIS
- Structure and Engineering of Francisella novicida Cas9
- (2016) Hisato Hirano et al. CELL
- Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
- (2016) Addison V. Wright et al. CELL
- CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs
- (2016) Mohammad A. Mandegar et al. Cell Stem Cell
- Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing
- (2016) Xiangjin Kang et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice
- (2016) Yang Yang et al. NATURE BIOTECHNOLOGY
- Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
- (2016) Hao Yin et al. NATURE BIOTECHNOLOGY
- Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts
- (2016) Kazuhiro Umeyama et al. Scientific Reports
- Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries
- (2015) M. Beaudoin et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Nucleosomes Inhibit Cas9 Endonuclease Activity in Vitro
- (2015) John M. Hinz et al. BIOCHEMISTRY
- Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency
- (2015) Christina V. Theodoris et al. CELL
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
- (2015) Chen Yu et al. Cell Stem Cell
- Cold-Inducible RNA-Binding Protein Regulates Cardiac Repolarization by Targeting Transient Outward Potassium Channels
- (2015) J. Li et al. CIRCULATION RESEARCH
- Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration
- (2015) Jingli Cao et al. DEVELOPMENT
- Exacerbating Pressure Overload–Induced Cardiac HypertrophyNovelty and Significance
- (2015) Xuehai Zhu et al. HYPERTENSION
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- Conformational control of DNA target cleavage by CRISPR–Cas9
- (2015) Samuel H. Sternberg et al. NATURE
- A mechanism for the suppression of homologous recombination in G1 cells
- (2015) Alexandre Orthwein et al. NATURE
- Genetic compensation induced by deleterious mutations but not gene knockdowns
- (2015) Andrea Rossi et al. NATURE
- In vivo genome editing using Staphylococcus aureus Cas9
- (2015) F. Ann Ran et al. NATURE
- Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
- (2015) Takeshi Maruyama et al. NATURE BIOTECHNOLOGY
- Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
- (2015) Benjamin P Kleinstiver et al. NATURE BIOTECHNOLOGY
- Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
- (2015) Van Trung Chu et al. NATURE BIOTECHNOLOGY
- Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
- (2015) Daesik Kim et al. NATURE METHODS
- A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9
- (2015) Kelli J. Carroll et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
- (2015) J. T. Hinson et al. SCIENCE
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- Dynamics of CRISPR-Cas9 genome interrogation in living cells
- (2015) Spencer C. Knight et al. SCIENCE
- Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy
- (2015) C. Long et al. SCIENCE
- In vivo gene editing in dystrophic mouse muscle and muscle stem cells
- (2015) M. Tabebordbar et al. SCIENCE
- In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
- (2015) C. E. Nelson et al. SCIENCE
- Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
- (2015) Ioannis Karakikes et al. Nature Communications
- Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA
- (2015) Yong Wang et al. Scientific Reports
- CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
- (2015) Puping Liang et al. Protein & Cell
- Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression
- (2015) Marek M. Nagiec et al. PLoS One
- Efficient Multiple Genome Modifications Induced by the crRNAs, tracrRNA and Cas9 Protein Complex in Zebrafish
- (2015) Hirohito Kotani et al. PLoS One
- klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes
- (2015) Peter Novodvorsky et al. PLoS One
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
- (2014) Randall J. Platt et al. CELL
- Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
- (2014) Luke A. Gilbert et al. CELL
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
- (2014) Yuyu Niu et al. CELL
- Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells
- (2014) Yuxuan Wu et al. CELL RESEARCH
- Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing
- (2014) Adrian Veres et al. Cell Stem Cell
- TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys
- (2014) Hailiang Liu et al. Cell Stem Cell
- Whole-Genome Sequencing Analysis Reveals High Specificity of CRISPR/Cas9 and TALEN-Based Genome Editing in Human iPSCs
- (2014) Cory Smith et al. Cell Stem Cell
- Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
- (2014) Qiurong Ding et al. CIRCULATION RESEARCH
- Multiple genome modifications by the CRISPR/Cas9 system in zebrafish
- (2014) Satoshi Ota et al. GENES TO CELLS
- Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9
- (2014) Rajat M. Gupta et al. JOURNAL OF CLINICAL INVESTIGATION
- Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing
- (2014) Yongming Wang et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
- (2014) James J. H. Chong et al. NATURE
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
- (2014) John P Guilinger et al. NATURE BIOTECHNOLOGY
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
- (2014) Gang Wang et al. NATURE MEDICINE
- Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
- (2014) Bin Shen et al. NATURE METHODS
- Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV
- (2014) Pablo Tebas et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bioluminescent Imaging of Genetically Selected Induced Pluripotent Stem Cell-Derived Cardiomyocytes after Transplantation into Infarcted Heart of Syngeneic Recipients
- (2014) Vera Lepperhof et al. PLoS One
- Characterization of Dystrophin Deficient Rats: A New Model for Duchenne Muscular Dystrophy
- (2014) Thibaut Larcher et al. PLoS One
- Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat
- (2014) B. T. Endres et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue
- (2014) Miao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
- (2014) C. Long et al. SCIENCE
- Efficient creation of an APOE knockout rabbit
- (2014) Diana Ji et al. TRANSGENIC RESEARCH
- Effective gene targeting in rabbits using RNA-guided Cas9 nucleases
- (2014) Dongshan Yang et al. Journal of Molecular Cell Biology
- Stable Enhanced Green Fluorescent Protein Expression After Differentiation and Transplantation of Reporter Human Induced Pluripotent Stem Cells Generated by AAVS1 Transcription Activator-Like Effector Nucleases
- (2014) Yongquan Luo et al. Stem Cells Translational Medicine
- Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells
- (2014) Dorothea Maetzel et al. Stem Cell Reports
- One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
- (2013) Haoyi Wang et al. CELL
- One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering
- (2013) Hui Yang et al. CELL
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
- (2013) Prashant Mali et al. NATURE BIOTECHNOLOGY
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
- (2013) Seung Woo Cho et al. NATURE BIOTECHNOLOGY
- Efficient genome editing in zebrafish using a CRISPR-Cas system
- (2013) Woong Y Hwang et al. NATURE BIOTECHNOLOGY
- High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
- (2013) Vikram Pattanayak et al. NATURE BIOTECHNOLOGY
- High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
- (2013) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
- (2013) Kevin M Esvelt et al. NATURE METHODS
- Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
- (2013) Teresa Coelho et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
- (2013) Z. Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Allele-Specific Silencing of Mutant Myh6 Transcripts in Mice Suppresses Hypertrophic Cardiomyopathy
- (2013) Jianming Jiang et al. SCIENCE
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models
- (2012) Qiurong Ding et al. Cell Stem Cell
- Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells With Zinc Finger Nucleases for Cellular Imaging
- (2012) Yongming Wang et al. CIRCULATION RESEARCH
- A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart
- (2012) H Steve Zhang et al. MOLECULAR THERAPY
- Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
- (2012) Yuji Shiba et al. NATURE
- Targeted Genomic Integration of a Selectable Floxed Dual Fluorescence Reporter in Human Embryonic Stem Cells
- (2012) Jay A. Gantz et al. PLoS One
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Creation and Characterization of a Renin Knockout Rat
- (2011) Carol Moreno et al. HYPERTENSION
- TAL Effectors: Customizable Proteins for DNA Targeting
- (2011) A. J. Bogdanove et al. SCIENCE
- Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
- (2010) M. Christian et al. GENETICS
- Genome editing with engineered zinc finger nucleases
- (2010) Fyodor D. Urnov et al. NATURE REVIEWS GENETICS
- Gene targeting in the rat: advances and opportunities
- (2010) Howard J. Jacob et al. TRENDS IN GENETICS
- Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
- (2009) J. Boch et al. SCIENCE
- A Simple Cipher Governs DNA Recognition by TAL Effectors
- (2009) M. J. Moscou et al. SCIENCE
- Regulation of DNA repair throughout the cell cycle
- (2008) Dana Branzei et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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