期刊
NATURE NEUROSCIENCE
卷 19, 期 6, 页码 788-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4301
关键词
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资金
- James S. McDonnell Foundation
- CIRM Grant [TB1-01175]
- G. Harold & Leila Y. Mathers Charitable Foundation
- JPB Foundation
- NIH [MH095741, MH092758]
- Leona M. and Harry B. Helmsley Charitable Trust [2012-PG-MED00]
- Salk Innovation Grant
- Lewis Biophotonics Fellowship
We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.
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