Involvement of the Opioidergic Mechanism in the Analgesic Potential of a Novel Indazolone Derivative: Efficacy in the Management of Pain, Neuropathy, and Inflammation Using In Vivo and In Silico Approaches

In-Silico Lead Druggable Compounds Identification against SARS COVID-19 Main Protease Target from In-House, Chembridge and Zinc Databases by Structure-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations

(2023) Mehreen Ghufran et al.   Bioengineering

Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms

(2022) Faiz Ali Khan et al.   MOLECULES

Synthesis of Spiro‐oxindole Analogs Engrafted Pyrazole Scaffold as Potential Alzheimer's Disease Therapeutics: Anti‐oxidant, Enzyme Inhibitory and Molecular Docking Approaches

(2022) Mohammad Shahidul Islam et al.   ChemistrySelect

In Silico Strategies for Designing of Peptide Inhibitors of Oncogenic K-Ras G12V Mutant: Inhibiting Cancer Growth and Proliferation

(2022) Mehreen Ghufran et al.   Cancers

In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease

(2022) Mater H. Mahnashi et al.   Metabolites

Synthesis, molecular docking and enzyme inhibitory approaches of some new chalcones engrafted pyrazole as potential antialzheimer, antidiabetic and antioxidant agents

(2022) Mohammad Shahidul Islam et al.   JOURNAL OF MOLECULAR STRUCTURE

Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone

(2021) Rahim Ullah et al.   NEUROCHEMISTRY INTERNATIONAL

Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia

(2021) Nisar Ahmad et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Strategies towards safer opioid analgesics—A review of old and upcoming targets

(2021) Balazs R. Varga et al.   BRITISH JOURNAL OF PHARMACOLOGY

6-Methoxyflavanone abates cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: A behavioral and molecular simulation study

(2020) Shehla Akbar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives

(2020) Ashfaq Ahmad et al.   Drug Design Development and Therapy

Involvement of selective GABA-A receptor subtypes in amelioration of cisplatin-induced neuropathic pain by 2’-chloro-6-methyl flavone (2’-Cl-6MF)

(2020) Nasiara Karim et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Treating Hyperglycemia From Eryngium caeruleum M. Bieb: In-vitro α-Glucosidase, Antioxidant, in-vivo Antidiabetic and Molecular Docking-Based Approaches

(2020) Abdul Sadiq et al.   Frontiers in Chemistry

In vitro cholinesterase enzymes inhibitory potential and in silico molecular docking studies of biogenic metal oxides nanoparticles

(2019) Ali Talha Khalil et al.   Inorganic and Nano-Metal Chemistry

In-silico design of peptide inhibitors of K-Ras target in cancer disease

(2019) Mehreen Ghufran et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators

(2019) Hongguang Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms

(2016) Urooj Aman et al.   BMC Complementary and Alternative Medicine

Anti-nociceptive Activity of Ethnomedicinally Important Analgesic Plant Isodon rugosus Wall. ex Benth: Mechanistic Study and Identifications of Bioactive Compounds

(2016) Anwar Zeb et al.   Frontiers in Pharmacology

Electroacupuncture in conscious free-moving mice reduces pain by ameliorating peripheral and central nociceptive mechanisms

(2016) Ying Wang et al.   Scientific Reports

Efficient synthesis of highly substituted tetrahydroindazolone derivatives

(2015) Angela Scala et al.   MOLECULAR DIVERSITY

Pharmacological evaluation, molecular docking and dynamics simulation studies of salicyl alcohol nitrogen containing derivatives

(2014) Gowhar Ali   African Journal of Pharmacy and Pharmacology

Effect of curcumin in mice model of vincristine-induced neuropathy

(2014) Anand Babu et al.   PHARMACEUTICAL BIOLOGY

Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin

(2014) Neeraj Khatri et al.   Journal of Diabetes Research

Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects

(2013) Alba Vidal-Torres et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adverse Effects Associated with Non-opioid and Opioid Treatment in Patients with Chronic Pain

(2012) Roberto Labianca et al.   CLINICAL DRUG INVESTIGATION

A New Route to Indazolone via Amidation Reaction of o-Carboxyazobenzene

(2012) Chengjie Li et al.   ORGANIC LETTERS

The FDA Critical Path Initiative and Its Influence on New Drug Development

(2008) Janet Woodcock et al.   Annual Review of Medicine