Inflammatory signaling in human tuberculosis granulomas is spatially organized

A Sterilizing Tuberculosis Treatment Regimen Is Associated with Faster Clearance of Bacteria in Cavitary Lesions in Marmosets

(2015) Laura E. Via et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The association between sterilizing activity and drug distribution into tuberculosis lesions

(2015) Brendan Prideaux et al.   NATURE MEDICINE

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

(2015) Hannah Priyadarshini Gideon et al.   PLoS Pathogens

Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study

(2015) Selvakumar Subbian et al.   PLoS One

Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation duringMycobacterium tuberculosisInfection

(2014) Nicholas A. Cilfone et al.   JOURNAL OF IMMUNOLOGY

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF- 

(2014) R. C. J. D'Souza et al.   Science Signaling

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

TB: the Yin and Yang of lipid mediators

(2013) David M Tobin et al.   CURRENT OPINION IN PHARMACOLOGY

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

(2013) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase

(2013) Jennifer A. Mietla et al.   JOURNAL OF LIPID RESEARCH

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

(2013) Philana Ling Lin et al.   NATURE MEDICINE

Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection

(2013) Nicholas A. Cilfone et al.   PLoS One

Modeling the Mycobacterium tuberculosis Granuloma – the Critical Battlefield in Host Immunity and Disease

(2013) Evelyn Guirado et al.   Frontiers in Immunology

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [18F]2-Fluoro-Deoxy-d-Glucose Positron Emission Tomography and Computed Tomography

(2012) Laura E. Via et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions

(2011) Brendan Prideaux et al.   ANALYTICAL CHEMISTRY

A Spotlight on Liquefaction: Evidence from Clinical Settings and Experimental Models in Tuberculosis

(2011) Pere-Joan Cardona   Clinical & Developmental Immunology

Multiscale Computational Modeling Reveals a Critical Role for TNF-  Receptor 1 Dynamics in Tuberculosis Granuloma Formation

(2011) M. Fallahi-Sichani et al.   JOURNAL OF IMMUNOLOGY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer

(2011) Annette Michalski et al.   MOLECULAR & CELLULAR PROTEOMICS

Reactivation of M. tuberculosis Infection in Trans-Membrane Tumour Necrosis Factor Mice

(2011) Ivy Dambuza et al.   PLoS One

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response

(2011) S. Subbian et al.   Open Biology

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Proteome, Phosphoproteome, and N-Glycoproteome Are Quantitatively Preserved in Formalin-Fixed Paraffin-Embedded Tissue and Analyzable by High-Resolution Mass Spectrometry

(2010) Paweł Ostasiewicz et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative Analysis of Kinase-Proximal Signaling in Lipopolysaccharide-Induced Innate Immune Response

(2010) Kirti Sharma et al.   JOURNAL OF PROTEOME RESEARCH

Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis

(2010) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Who Benefits from Granulomas, Mycobacteria or Host?

(2009) Tyler D. Bold et al.   CELL

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

(2009) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death

(2008) Hilary Clay et al.   IMMUNITY

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens

Adaptive correction technique for 3D reconstruction of fluorescence microscopy images

(2007) Y.Q. Guan et al.   MICROSCOPY RESEARCH AND TECHNIQUE