期刊
NATURE IMMUNOLOGY
卷 17, 期 6, 页码 687-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3422
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- Ministry of Health, Labour and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology of Japan [25253030, 25115502, 23112701, 25713032]
- IRYO HOJIN SHADAN JIKOKAI
- Kato Memorial Bioscience Foundation
- Yasuda Medical Foundation
- Takeda Science Foundation
- Akiyama Life Science Foundation
- Canadian Institutes of Health Research (CIHR) grant [496441]
- Canadian Institutes of Health Research operating grant [MOP-125919]
- Canadian Institutes of Health Research New Investigator Award
- Early Researcher Award from the Ontario Ministry of Innovation
- Waksman Foundation of Japan
- Grants-in-Aid for Scientific Research [24390110, 15H01249, 25713032, 25253030, 25115502] Funding Source: KAKEN
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic activity of many environmental xenobiotics. However, its role in innate immune responses during viral infection is not fully understood. Here we demonstrate that constitutive AHR signaling negatively regulates the type I interferon (IFN-I) response during infection with various types of virus. Virus-induced IFN-beta production was enhanced in AHR-deficient cells and mice and resulted in restricted viral replication. We found that AHR upregulates expression of the ADP-ribosylase TIPARP, which in turn causes downregulation of the IFN-I response. Mechanistically, TIPARP interacted with the kinase TBK1 and suppressed its activity by ADP-ribosylation. Thus, this study reveals the physiological importance of endogenous activation of AHR signaling in shaping the IFN-I-mediated innate response and, further, suggests that the AHR-TIPARP axis is a potential therapeutic target for enhancing antiviral responses.
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