Article
Veterinary Sciences
Luisa D'Angelo, Rubina Paradiso, Domenico Alfano, Marita Georgia Riccardi, Giorgia Borriello, Giorgio Galiero
Summary: This study describes the first detection of Salmonella enterica subsp. enterica Serovar Enteritidis in an aborted water buffalo fetus in southern Italy, providing significant insights into the role of S. Enteritidis in causing abortion in water buffalo.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Johanna Fjelkner, Cecilia Hulten, Magdalena Jacobson, Erik Norregard, Beth Young
Summary: This report describes the detection of Salmonella enterica subspecies enterica serovar Choleraesuis in a Swedish pig farm after a 40-year absence. The investigation revealed possible transmission routes and implemented measures to eliminate the pathogen from the herd.
PORCINE HEALTH MANAGEMENT
(2023)
Article
Microbiology
Petra Geiser, Maria Letizia Di Martino, Pilar Samperio Ventayol, Jens Eriksson, Eduardo Sima, Anas Kh. Al-Saffar, David Ahl, Mia Phillipson, Dominic-Luc Webb, Magnus Sundbom, Per M. Hellstrom, Mikael E. Sellin
Summary: This study reveals the complete infection cycle of Salmonella enterica serovar Typhimurium within human and mouse enteroids, and demonstrates how bacterial invasion of the epithelium strongly fuels expansion in the luminal compartment through a mechanism involving the death and expulsion of bacterium-infected epithelial cells.
Article
Microbiology
Yu-feng Qiu, Reshma B. Nambiar, Xue-bin Xu, Shun-tai Weng, Hang Pan, Kui-cheng Zheng, Min Yue
Summary: Non-typhoidal Salmonella (NTS) is a common cause of gastroenteritis, with the invasive infection caused by an infrequently reported serovar Telelkebir strain FJ001 in China carrying antimicrobial-resistant and typhoidtoxin genes. Genomic investigation revealed a high relatedness among global S. Telelkebir isolates, suggesting potential rapid transmissions through international travels. This study highlights the importance of surveillance and understanding the threat posed by the unique combination of virulent and antimicrobial-resistant determinants in NTS infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Stephy Mol Robinson, Vyshakh Rajachandran, Suchismita Majumdar, Satabdi Saha, Sneha Das, Sujay Chattopadhyay
Summary: Detecting adaptive mutations leading to gene inactivation or loss of function is crucial for understanding the evolution of bacterial virulence and antibiotic resistance. Truncation mutations, which trim the length of encoded proteins, can contribute to gene inactivation. This study analyzed the accumulation of truncation mutations in two serovars of Salmonella, finding distinct sets of core truncated genes in each serovar. These truncation mutations were acquired by different subsets of isolates and were also targeted by convergent amino acid mutations in different serovars, suggesting adaptation. Further research is needed to investigate the impact of adaptive truncation mutations on bacterial virulence evolution.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Fabio Fiorino, Elena Pettini, Oliver Koeberling, Annalisa Ciabattini, Gianni Pozzi, Laura B. Martin, Donata Medaglini
Summary: STm vaccine based on GMMA technology can induce long-lasting anti-bacterial immunity in mice and have a preventive effect on iNTS disease.
Article
Medicine, General & Internal
Daniela Pi Noa, Rodrigo Podesta, Joshua Costin, Soling Li
Summary: Vertebral discitis is a rare infection of the vertebrae, commonly caused by Staphylococcus aureus. This case report presents a 24-year-old Asian male without any medical history or trauma, who was diagnosed with Salmonella discitis, an even rarer form of the disease. The importance of considering Salmonella as a possible causative agent in cases of vertebral discitis is highlighted.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Immunology
Katarzyna Kosznik-Kwasnicka, Magdalena Podlacha, Lukasz Grabowski, Malgorzata Stasilojc, Alicja Nowak-Zaleska, Karolina Cieminska, Zuzanna Cyske, Aleksandra Dydecka, Lidia Gaffke, Jagoda Mantej, Dorota Myslinska, Agnieszka Necel, Karolina Pierzynowska, Ewa Piotrowska, Edyta Radzanowska-Alenowicz, Estera Rintz, Krzysztof Sitko, Gracja Topka-Bielecka, Grzegorz Wegrzyn, Alicja Wegrzyn
Summary: Phage therapy is as effective as antibiotic therapy in treating Salmonella Typhimurium infection in chickens, with fewer changes to the microbiome.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Teresa Garcia-Seco, Carlos Montbrau, Mireia Fontseca, Ricard March, Marta Sitja, Lucas Dominguez, Javier Bezos
Summary: The study evaluated the efficacy of a new commercial inactivated vaccine for controlling S. Abortusovis infection in sheep, showing significant decrease in abortion percentage and overall vaginal excretion in the vaccinated group compared to the control group. These results indicate that the vaccine is an effective alternative for controlling S. Abortusovis infection in ovine flocks.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Xinwu Wang, Yating Xing, Yalu Ji, Hengyu Xi, Xiaohe Liu, Li Yang, Liancheng Lei, Wenyu Han, Jingmin Gu
Summary: This study investigates the therapeutic effect of two phages, vB_SenS-EnJE1 and vB_SenS-EnJE6, in combination with fecal microbiota transplantation (FMT) on S. Typhimurium-induced mouse colitis. Results show that the combination of phages and FMT completely removes S. Typhimurium, improves pathological damage, restores the intestinal barrier, and enhances intestinal microbial diversity and levels of short-chain fatty acids (SCFA).
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Junyan Qu, Zhiyong Zong
Summary: Splenic cyst complicated with non-typhoid Salmonella infection is uncommon in healthy individuals in the antibiotic era. This case report describes a giant splenic cyst (21 cm in diameter) complicated by Salmonella Livingstone infection in a previously healthy 16-year-old male. The splenic abscess was successfully treated with ultrasonography-guided percutaneous drainage and antimicrobial therapy. This case highlights the occurrence of splenic cyst infection caused by S. Livingstone in immunocompetent individuals and emphasizes the importance of drainage and antimicrobial agents to avoid splenectomy.
BMC INFECTIOUS DISEASES
(2022)
Article
Microbiology
Jingyan Shu, Hongtao Liu, Yang Liu, Xindi Chen, Yu Yu, Qianghua Lv, Jianfeng Wang, Xuming Deng, Zhimin Guo, Jiazhang Qiu
Summary: Tannic acid (TA) has been shown to improve survival rates and alleviate cecal pathological lesions in S. Typhimurium-infected mice, while inhibiting bacterial invasion of HeLa cells. TA may exert its anti-infection effects by controlling the expression of key genes in the T3SS.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Meiying Yan, Yongming Zhou, Yang Cao, Zhenpeng Li, Xin Lu, Bo Pang, Shukun Wang, Biao Kan
Summary: This study discovered a new serovar of Salmonella (S. enterica subsp. II serovar 4,5,12:a:-) and demonstrated its ability to infect humans and cause clusters of cases. Whole-genome sequencing detection and surveillance of Salmonella can accurately define Salmonella classification and clonality, improve diagnosis, facilitate outbreak detection, and aid in the source tracing of salmonellosis epidemics.
Article
Infectious Diseases
Xenia Vazquez, Lorena Forcelledo, Salvador Balboa-Palomino, Javier Fernandez, Maria Rosario Rodicio
Summary: This report describes a rare case of nosocomial pneumonia caused by multidrug-resistant Salmonella enterica in an immunocompetent patient. Genome sequencing revealed that the isolates from this patient were closely related and belonged to the emergent ST34 monophasic variant of S. enterica serovar Typhimurium. This case highlights the development of resistance to highly relevant antibiotics due to treatment-associated selection pressure.
Article
Immunology
Jessica C. Allen, Franklin R. Toapanta, Scott M. Baliban, Marcelo B. Sztein, Sharon M. Tennant
Summary: Non-typhoidal Salmonella (NTS) is a significant cause of foodborne infections and deaths worldwide. We have developed a live attenuated vaccine, CVD 1926, against Salmonella enterica serovar Typhimurium. The study found that older mice had weaker immune responses to the vaccine and mucosal responses decrease with age.
FRONTIERS IN IMMUNOLOGY
(2023)