Article
Immunology
Kelly Graff, Christiana Smith, Lori Silveira, Sarah Jung, Shane Curran-Hays, Jane Jarjour, Lauren Carpenter, Kasey Pickard, Michael Mattiucci, JoEllen Fresia, Elizabeth J. McFarland, Samuel R. Dominguez, Lisa Abuogi
Summary: This study found that extremes of age, comorbid conditions, and elevated CRP are predictors of severe COVID-19 disease in children. These findings can help pediatric providers and public health officials tailor clinical management and resource allocation strategies more effectively.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Health Care Sciences & Services
Melchor Alvarez-Mon, Miguel A. Ortega, Oscar Gasulla, Jordi Fortuny-Profitos, Ferran A. Mazaira-Font, Pablo Saurina, Jorge Monserrat, Maria N. Plana, Daniel Troncoso, Jose Sanz Moreno, Benjamin Munoz, Alberto Arranz, Jose F. Varona, Alejandro Lopez-Escobar, Angel Asunsolo-del Barco
Summary: This study aimed to create an individualized analysis model of ICU admission or death risk for COVID-19 patients to optimize medical resource management. Using data from 3489 COVID-19 patients, variables like oxygen saturation, age, and comorbidities were found to have significant impact. A predictive model was established to categorize patients into low, medium, and high-risk levels for ICU admission or death outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Weihua Wu, Xulei Zhang, Yuxin Chen, Baofeng Wang, Jing Wu, Yali Xiong, Bei Jia, Jian Wang, Juan Xia, Yangjuan Pu, Wensan Zhou, Zhong Chen, Zhaoping Zhang, Xiaomin Yan, Rui Huang, Chao Wu
Summary: The study identified platelet counts and C-reactive protein levels as independent risk factors for fatal outcome in hospitalized COVID-19 patients. Both platelet counts and CRP levels have relatively high accuracy in predicting fatal outcomes.
DISCOVERY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Sen Yang, Huaxin Zhao, Ran Cui, Le Ma, Xuhua Ge, Qiangqiang Fu, Dehua Yu, Xiaomin Niu
Summary: This study found that increased CRP and LDH were risk factors for severe events in all COVID-19 patients. Compared to noncancer patients, cancer patients undergoing regular follow-up without anticancer treatment had a higher incidence of hypoalbuminemia complications and longer hospitalization.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Cinthya Pena Orbea, Lu Wang, Vaishal Shah, Lara Jehi, Alex Milinovich, Nancy Foldvary-Schaefer, Mina K. Chung, Saif Mashaqi, Loutfi Aboussouan, Kelsey Seidel, Reena Mehra
Summary: In this case-control study, SDB and sleep-related hypoxia were not associated with increased SARS-CoV-2 positivity; however, once patients were infected with SARS-CoV-2, sleep-related hypoxia was an associated risk factor for detrimental COVID-19 outcomes.
Article
Infectious Diseases
Yi Zhou, Qiao Yang, Jun Ye, Xiaocheng Wu, Xianhua Hou, Yimei Feng, Bangyu Luo, Jixi Li, Guangrong Yang, Lingchen Li, Xiu Yang, Bin Wang, Songtao Zhao, Li Li, Qi Li, Zhi Xu, Hao Wu, Jianguo Sun
Summary: A retrospective study was conducted on 103 COVID-19 patients with cancer to analyze their clinical features and determine death outcome related risk factors. The study found significant differences in clinical features and laboratory results between severe and non-severe patients, with NLR and CRP identified as predictors of death outcome.
BMC INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Ibrahim Halil Ozdemir, Bulent Ozlek, Mehmet Burak Ozen, Ramazan Gunduz, Nurullah Cetin, Eda Ozlek, Bekir Serhat Yildiz, Ali Riza Bilge
Summary: The study showed that the C-reactive protein/albumin ratio can serve as a strong and independent prognostic marker for predicting mortality and disease progression in hypertensive COVID-19 patients.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Immunology
Blanca Molins, Marc Figueras-Roca, Oliver Valero, Victor Llorenc, Sara Romero-Vazquez, Oriol Sibila, Alfredo Adan, Carolina Garcia-Vidal, Alex Soriano
Summary: In COVID-19 patients, monomeric CRP levels are associated with disease severity, and levels higher than 4000 ng/mL independently predict disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ana M. Camon, Rodrigo Alonso, Francisco J. Munoz, Celia Cardozo, Javier Bernal-Maurandi, Laia Albiach, Daiana Aguero, M. Angeles Marcos, Juan Ambrosioni, Marta Bodro, Mariana Chumbita, Lorena De la Mora, Nicole Garcia-Pouton, Gerard Duenas, Marta Hernandez-Meneses, Alexy Inciarte, Genoveva Cuesta, Fernanda Meira, Laura Morata, Pedro Puerta-Alcalde, Veronica Rico, Sabina Herrera, Montse Tuset, Pedro Castro, Sergio Prieto-Gonzalez, Alex Almuedo, Jose Munoz, Josep Mensa, Gemma Sanjuan, J. M. Nicolas, Ana Del Rio, Jordi Vila, Felipe Garcia, Jose Antonio Martinez, Carolina Garcia-Vidal, Alex Soriano
Summary: C-reactive protein (CRP) can be used to identify patients who require anti-inflammatory therapy in COVID-19 infections. Dexamethasone and tocilizumab have been found to reduce mortality rates, especially in patients with high CRP levels.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Hui An, Jitai Zhang, Tong Zhou, Ting Li, Shan Li, Caili Huang, Chengshui Chen, Binyu Ying, Zhangye Xu, Shengwei Jin, Xiaokun Li, Ming Li
Summary: This study monitored the dynamic progression of inflammation/coagulopathy/fibrinolysis (ICF) in patients with moderate COVID-19, revealing two ICF fluctuations triggered by virus-induced damages. After 12-day medication, some indicators were restored to normal levels, but D-dimer levels remained high. It is notable that critical COVID-19 patients exhibited high D-dimer levels despite normal values in other coagulation parameters.
CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Rasoul Kowsar, Amir Mohammad Rahimi, Magdalena Sroka, Alireza Mansouri, Khaled Sadeghi, Elham Bonakdar, Sayed Farshad Kateb, Amir Hossein Mahdavi
Summary: Understanding the hematological/biochemical characteristics, pre-existing health conditions, and complications in COVID-19 patients can help predict mortality rates, ICU referrals, and deaths.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Li Yin Tan, Thamil Vaani Komarasamy, Vinod R. M. T. Balasubramaniam
Summary: COVID-19 caused by SARS-CoV-2 can lead to severe health consequences, including acute respiratory distress syndrome and multi-organ failure, through activation of inflammatory pathways and cytokine storm. Long-term effects, particularly on the brain, are of concern.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ying-yi Luan, Cheng-hong Yin, Yong-ming Yao
Summary: High levels of CRP in severe COVID-19 and other viral infections can indicate disease progression and guide clinical diagnosis and antibiotic therapy. Understanding the role of CRP in these diseases may lead to more effective prevention and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Annabella Di Giorgio, Antonio Mirijello, Clara De Gennaro, Andrea Fontana, Paolo Emilio Alboini, Lucia Florio, Vincenzo Inchingolo, Michele Zarrelli, Giuseppe Miscio, Pamela Raggi, Carmen Marciano, Annibale Antonioni, Salvatore De Cosmo, Filippo Aucella, Antonio Greco, Massimo Carella, Massimiliano Copetti, Maurizio A. Leone
Summary: Delirium is a strong predictor of poor outcomes in COVID-19 patients, particularly the hypoactive subtype. Dementia, age, C-reactive protein, and Glasgow Coma Scale are associated with the occurrence of delirium.
Article
Virology
Jun-Hong Wang, Ru-Dong Chen, Hong-Kuan Yang, Ling-Cheng Zeng, Hao Chen, Yu-Yang Hou, Wei Hu, Jia-Sheng Yu, Hua Li
Summary: In this study, it was found that inflammation-associated factors were significantly associated with in-hospital mortality in COVID-19 patients. C-reactive protein, neutrophil count, and interleukin 6 were identified as independent predictors of in-hospital death, suggesting their potential for early identification and improved management of high-risk patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)