期刊
NATURE GENETICS
卷 48, 期 10, 页码 1211-1217出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3644
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资金
- Wellcome Trust [098051, WT092152MA, 101113/Z/13/Z]
- Institut Pasteur
- Institut de Veille Sanitaire
- French government 'Investissement d'Avenir' program (Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence) [ANR-10-LABX-62-IBEID]
- NIH [R01 AI099525-02]
- Biotechnology and Biological Sciences Research Council at the University of Cambridge [BB/M014088/1]
- antibiotic resistance surveillance project in the Democratic Republic of the Congo - Belgian Directorate General of Development Cooperation (Antwerp, Belgium)
- antibiotic resistance surveillance project in the Democratic Republic of the Congo - Institute of Tropical Medicine (Antwerp, Belgium)
- Wellcome Trust [101113/Z/13/Z] Funding Source: Wellcome Trust
- BBSRC [BB/M014088/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M014088/1] Funding Source: researchfish
An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
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