期刊
NATURE CHEMICAL BIOLOGY
卷 12, 期 11, 页码 902-+出版社
NATURE PORTFOLIO
DOI: 10.1038/NCHEMBIO.2176
关键词
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资金
- National Institute of Allergy and Infectious Diseases grant [U54 AI057159]
- US National Institutes of Health grant [R01 GM081617, GM086258]
- European Research Council FP7 ERC grant [281891]
- National Science Foundation Graduate Fellowship
We developed a competition-based screening strategy to identify compounds that invert the selective advantage of antibiotic resistance. Using our assay, we screened over 19,000 compounds for the ability to select against the TetA tetracycline-resistance efflux pump in Escherichia coli and identified two hits, beta-thujaplicin and disulfiram. Treating a tetracycline-resistant population with beta-thujaplicin selects for loss of the resistance gene, enabling an effective second-phase treatment with doxycycline.
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