Lung tumor–infiltrating T reg have divergent transcriptional profiles and function linked to checkpoint blockade response
出版年份 2023 全文链接
标题
Lung tumor–infiltrating T
reg
have divergent transcriptional profiles and function linked to checkpoint blockade response
作者
关键词
-
出版物
Science Immunology
Volume 8, Issue 87, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2023-09-16
DOI
10.1126/sciimmunol.adg1487
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory
- (2022) Yujiro Kidani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NKG7 Is Required for Optimal Antitumor T-cell Immunity
- (2022) Xian-Yang Li et al. Cancer Immunology Research
- Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity
- (2022) Yonglin Chen et al. Frontiers in Immunology
- Chemokine Receptor-Targeted Therapies: Special Case for CCR8
- (2022) Bernhard Moser Cancers
- Landscape of helper and regulatory antitumour CD4+ T cells in melanoma
- (2022) Giacomo Oliveira et al. NATURE
- Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer
- (2022) Patrick M. Forde et al. NEW ENGLAND JOURNAL OF MEDICINE
- Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC)
- (2022) Zhenzhen Hui et al. Cell Death & Disease
- MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2
- (2022) Mengmeng Jiang et al. Journal for ImmunoTherapy of Cancer
- Regulatory T cells infiltrate the tumor-induced tertiary lymphoïd structures and are associated with poor clinical outcome in NSCLC
- (2022) Priyanka Devi-Marulkar et al. Communications Biology
- Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
- (2021) Helena Van Damme et al. Journal for ImmunoTherapy of Cancer
- Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
- (2021) Michael Delacher et al. IMMUNITY
- CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function
- (2021) Sarah K. Whiteside et al. IMMUNOLOGY
- STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets
- (2021) Dev Bhatt et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer
- (2021) Fengying Wu et al. Nature Communications
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
- (2021) Justina X. Caushi et al. NATURE
- Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy
- (2021) Simon Eschweiler et al. NATURE IMMUNOLOGY
- Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
- (2021) Yuechen Luo et al. Nature Communications
- The effects of TNF ‐α/ TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer
- (2021) Yang Qu et al. INTERNATIONAL JOURNAL OF CANCER
- Tumor necrosis factor receptor family co‐stimulation increases regulatory T cell activation and function via NF‐κB
- (2020) Martina Lubrano di Ricco et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer
- (2020) Anthony R. Cillo et al. IMMUNITY
- A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target
- (2020) Zachary T. Freeman et al. JOURNAL OF CLINICAL INVESTIGATION
- Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance
- (2020) Jeremy A. Sullivan et al. Cell Reports
- Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer
- (2020) David Y. Oh et al. CELL
- Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity
- (2020) Jacob A. Turner et al. IMMUNITY
- The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
- (2020) Susanna S. Ng et al. NATURE IMMUNOLOGY
- Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses
- (2019) S. J. Santegoets et al. Journal for ImmunoTherapy of Cancer
- Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation
- (2019) Ricardo J. Miragaia et al. IMMUNITY
- In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer
- (2019) Li He et al. eLife
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- Recharacterizing Tumor-Infiltrating Lymphocytes by Single-Cell RNA Sequencing
- (2019) Lei Zhang et al. Cancer Immunology Research
- CD4+ T cells indirectly kill tumor cells via induction of cytotoxic macrophages in mouse models
- (2019) Bjarne Bogen et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis
- (2019) Martina Di Giovangiulio et al. Frontiers in Immunology
- Fast, sensitive and accurate integration of single-cell data with Harmony
- (2019) Ilya Korsunsky et al. NATURE METHODS
- Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells
- (2019) Assaf Magen et al. Cell Reports
- Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC)
- (2018) T R Cottrell et al. ANNALS OF ONCOLOGY
- Targeting CCR8 induces protective antitumor immunity and enhances vaccine-induced responses in colon cancer
- (2018) Daniel O Villarreal et al. CANCER RESEARCH
- Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
- (2018) David Zemmour et al. NATURE IMMUNOLOGY
- Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
- (2018) Xinyi Guo et al. NATURE MEDICINE
- Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
- (2018) Patrick M. Forde et al. NEW ENGLAND JOURNAL OF MEDICINE
- Association of Immune‐Related Adverse Events with Clinical Benefit in Patients with Advanced Non‐Small‐Cell Lung Cancer Treated with Nivolumab
- (2018) Yukihiro Toi et al. ONCOLOGIST
- Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
- (2018) Lei Zhang et al. NATURE
- Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen
- (2017) John D. Leonard et al. IMMUNITY
- Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations
- (2017) Susanne C van den Brink et al. NATURE METHODS
- The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues
- (2017) Ajithkumar Vasanthakumar et al. Cell Reports
- AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease
- (2016) Alexandra Kitz et al. EMBO REPORTS
- Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells
- (2016) Marco De Simone et al. IMMUNITY
- Systematic review: colitis associated with anti-CTLA-4 therapy
- (2015) A. Gupta et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms
- (2015) Jamie B. Spangler et al. IMMUNITY
- An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell–suppressive function and therapeutic efficacy
- (2015) J-s Do et al. Mucosal Immunology
- Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region
- (2015) Philippe Bégin et al. Clinical and Translational Allergy
- Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice
- (2014) S. Ganguly et al. BLOOD
- Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue
- (2014) Silvia Piconese et al. HEPATOLOGY
- Homeostasis and function of regulatory T cells (Tregs)in vivo: lessons from TCR-transgenic Tregs
- (2014) Kesley Attridge et al. IMMUNOLOGICAL REVIEWS
- Acquisition of Suppressive Function by Activated Human CD4+CD25- T Cells Is Associated with the Expression of CTLA-4 Not FoxP3
- (2014) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- The In Vivo Response of Naive CD4+T Cells
- (2014) Marc K. Jenkins JOURNAL OF IMMUNOLOGY
- Good guys gone bad: exTreg cells promote autoimmune arthritis
- (2014) Nicole Joller et al. NATURE MEDICINE
- Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response
- (2013) Samantha L. Bailey-Bucktrout et al. IMMUNITY
- Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
- (2013) Greg M. Delgoffe et al. NATURE
- Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
- (2013) S. Malchow et al. SCIENCE
- Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes
- (2011) Stephanie A. McClymont et al. JOURNAL OF IMMUNOLOGY
- Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease
- (2011) Margarita Dominguez-Villar et al. NATURE MEDICINE
- Helios Expression Is a Marker of T Cell Activation and Proliferation
- (2011) Tatiana Akimova et al. PLoS One
- Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
- (2010) Ye Zheng et al. NATURE
- Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection
- (2009) Guillaume Oldenhove et al. IMMUNITY
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