Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

High-throughput analysis of behavior for drug discovery

(2015) Vadim Alexandrov et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Behavioral signatures related to genetic disorders in autism

(2014) Hilgo Bruining et al.   Molecular Autism

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles

(2012) Kazushi Suzuki et al.   NEUROBIOLOGY OF DISEASE

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration

(2011) Dani Brunner et al.   BEHAVIOURAL PROCESSES

Early onset deficits on the delayed alternation task in the HdhQ92 knock-in mouse model of Huntington's disease

(2011) R.C. Trueman et al.   BRAIN RESEARCH BULLETIN

HD CAG-correlated gene expression changes support a simple dominant gain of function

(2011) Jessie C. Jacobsen et al.   HUMAN MOLECULAR GENETICS

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

(2011) L.A. Raymond et al.   NEUROSCIENCE

Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington's disease knock-in mice

(2010) Simon Brooks et al.   BRAIN RESEARCH BULLETIN

Huntington’s Disease is a disorder of the corpus striatum: Focus on Rhes (Ras homologue enriched in the striatum)

(2010) Srinivasa Subramaniam et al.   NEUROPHARMACOLOGY

Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington's Disease Shows No Benefit from CoQ10 or Minocycline

(2010) Liliana B. Menalled et al.   PLoS One

CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches

(2009) Douglas R. Langbehn et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Rule learning, visuospatial function and motor performance in the HdhQ92 knock-in mouse model of Huntington's disease

(2009) R.C. Trueman et al.   BEHAVIOURAL BRAIN RESEARCH

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

A patient with Huntington’s disease and long-surviving fetal neural transplants that developed mass lesions

(2008) C. Dirk Keene et al.   ACTA NEUROPATHOLOGICA

Time course of choice reaction time deficits in the HdhQ92 knock-in mouse model of Huntington's disease in the operant Serial Implicit Learning Task (SILT)

(2008) Rebecca C. Trueman et al.   BEHAVIOURAL BRAIN RESEARCH

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

CAG repeat lengths ≥335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse

(2008) I. Dragatsis et al.   NEUROBIOLOGY OF DISEASE

Strategies for the Use of Mixture-Based Synthetic Combinatorial Libraries: Scaffold Ranking, Direct Testing In Vivo, and Enhanced Deconvolution by Computational Methods

(2007) Richard A. Houghten et al.   JOURNAL OF COMBINATORIAL CHEMISTRY