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Health Care Sciences & Services
Son Kim Tran, Toan Hoang Ngo, Phi Hoang Nguyen, An Bao Truong, Giang Khanh Truong, Khoa Dang Dang Tran, Phuong Minh Vo, Phi The Nguyen, Thuan Tuan Nguyen, Phu Ngoc Thien Nguyen, Kien Trung Nguyen, Hung Do Tran
Summary: This study investigated the prevalence of hyperhomocysteinemia and its associated factors in newly diagnosed primary hypertension patients. The results showed that elevated blood total homocysteine levels were common in these patients and often correlated with age, gender, hypertension stage, and diabetes.
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Cell Biology
Annina S. Vischer, Gabriela M. Kuster, Raphael Twerenbold, Otmar Pfister, Qian Zhou, Andrea Villiger, Marko Poglitsch, Stephan Krahenbuhl, Michael Mayr, Stefan Osswald, Manuel Haschke, Thilo Burkard
Summary: Different antihypertensive drugs have significant effects on angiotensin II and Ang (1-7) concentrations, with perindopril and olmesartan showing distinct alterations favoring the anti-inflammatory axis.
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Pharmacology & Pharmacy
Seref Alpsoy, Burcin Dogan, Demet Ozkaramanli Gur, Aydin Akyuz, Cigdem Fidan, Savas Guzel, Berna Ozkoyuncu
Summary: The study found that the non-dipper hypertension group had lower levels of Salusin alpha and higher levels of Salusin beta, as well as higher left ventricular mass index. Salusin alpha, Salusin beta, and left ventricular mass index were identified as independent predictors of non-dipper hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
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Peripheral Vascular Disease
Muammer Karakayali, Timor Omar, Inanc Artac, Ibrahim Rencuzogullari, Yavuz Karabag, Ozturk Demir
Summary: Hypertension is considered high intravascular pressure, but impaired circadian blood pressure has been shown to contribute to poor clinical outcomes. The systemic immune-inflammation index (SII) based on platelet, neutrophil, and lymphocyte counts is a strong prognostic marker in cardiovascular disease. This study aimed to investigate the relationship between circadian blood pressure changes and SII in newly diagnosed hypertensive patients.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
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Endocrinology & Metabolism
Xia Deng, Zhensheng Cai, Yanyan Li, Xunan Wu, Li Zhao, Haoxiang Li, Ke Chen, Panpan Zhang, Chenxi Wang, Zhicong Zhao, Ling Yang, Guoyue Yuan
Summary: This study found that serum EDA levels were significantly higher in newly diagnosed type 2 diabetes mellitus patients, and positively correlated with various metabolic indexes such as body mass index and fasting plasma glucose. Additionally, EDA levels were independently associated with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
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Pharmacology & Pharmacy
Ahmet Seyda Yilmaz, Elif Ergul, Omer Faruk Cirakoglu, Nadir Emlek, Mustafa Cetin
Summary: The study found that a higher Prognostic Nutritional Index (PNI) is an independent predictor of left ventricular dysfunction in newly diagnosed hypertensive patients. Immunonutritional status may be used as an indicator of left ventricular function in patients with arterial hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
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Nutrition & Dietetics
Long Zhou, Hui Huang, Xiaoxiao Wen, Yu Chen, Jie Liao, Fuli Chen, Liancheng Zhao, Mingjiang Liu, Jianhong Tao, Gang Li
Summary: This study found that elevated levels of red blood cell folate are associated with an increased risk of cardiovascular mortality among hypertensive patients with elevated homocysteine, while serum folate has no such effects.
FRONTIERS IN NUTRITION
(2022)
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Oncology
Zinaida Stupakova, Iryna Diagil, Ulyana Melnyk, Oksana Karnabeda, Anna Sergeieva
Summary: This study investigated the factors associated with the risk of bleeding in newly diagnosed acute myeloid leukaemia (AML) patients through immunoenzymatic analysis and classical coagulation studies. The results showed that reduced activity of von Willebrand factor was associated with severe bleeding in AML patients. In addition, patients with bleeding signs had increased platelet count and fibrinogen concentration. These findings contribute to the diagnosis and treatment of haemorrhagic syndrome.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
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Peripheral Vascular Disease
Arzoo Mishra, Chander Grover, Archana Singal, Shiva Narang, Gopal Krishna Das
Summary: The study found that the newly diagnosed hypertensive patients had significantly lower capillary density compared to normotensive controls, with more morphological changes such as capillary disarray, dilation, and microhemorrhages. NFC plays an important role in detecting microvascular morphological alterations in hypertensive patients, which may help in early prediction of cardiovascular or renal complications.
MICROVASCULAR RESEARCH
(2021)
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Endocrinology & Metabolism
Yan-Yan Li, Xu-Nan Wu, Xia Deng, Pan-Pan Zhang, Hao-Xiang Li, Ke Chen, Dan-Ping Wu, Tian Gu, Chen-Xi Wang, Li Zhao, Dong Wang, Ling Yang, Guo-Yue Yuan
Summary: The study found that serum levels of Tsukushi significantly increase in patients with type 2 diabetes, and are independently associated with factors like BMI and blood glucose levels, suggesting a potential role in the pathogenesis of type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
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Endocrinology & Metabolism
Saijun Zhou, YuLing Zhang, TongDan Wang, Shuai Huang, Siyi Gong, Junmei Wang, Pei Yu
Summary: The study showed that canagliflozin improved renal oxygenation in newly diagnosed type 2 diabetes mellitus patients with normal renal function, independently of changes in renal blood perfusion.
DIABETES & METABOLISM
(2021)
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Oncology
Juliana Muller Bark, Avinash V. Karpe, James D. Doecke, Paul Leo, Rosalind L. Jeffree, Benjamin Chua, Bryan W. Day, David J. Beale, Chamindie Punyadeera
Summary: The study suggests that metabolomic and lipidomic profiles in saliva and blood can be used as complementary tools for assessing the response to therapy in GBM patients. Patients with unfavorable outcomes showed distinct changes in metabolites and lipids compared to patients with favorable outcomes. These findings indicate the potential of using these biomarkers as less invasive prognostic indicators, although further validation with larger cohorts is needed.
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Medicine, General & Internal
Anett Apitz, Thenral Socrates, Thilo Burkard, Michael Mayr, Annina S. Vischer
Summary: The study aimed to investigate the prevalence of left ventricular hypertrophy (LVH) in patients with arterial hypertension (AHT) and describe patients with severe LVH. The results showed that over half of the AHT patients (52.5%) had abnormal left ventricular geometry, and 7.3% had severe LVH. Patients with severe LVH were more likely to be male, older, have uncontrolled blood pressure (especially during sleep), receive multiple antihypertensive treatments, and have comorbidities compared to those with normal left ventricular geometry.
JOURNAL OF CLINICAL MEDICINE
(2023)
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Pharmacology & Pharmacy
Ali Bagci, Fatih Aksoy, Hasan Aydin Bas, Ismail Barkin Isik, Fatih Akkaya, Hikmet Orhan
Summary: The study revealed that the f(QRS-T) angle was significantly widened in patients with exaggerated MBPS, indicating a severe ventricular repolarization disorder in these patients. Both MBPS and T peak-end were identified as independent predictors of the f(QRS-T) angle.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Review
Hematology
Utkarsh Goel, Saad Usmani, Shaji Kumar
Summary: Major developments in the treatment of multiple myeloma have led to improvements in survival. The treatment approach is guided by factors such as patient age, comorbidities, and risk stratification into standard-risk or high-risk MM. Transplant eligible patients should receive induction therapy followed by stem cell transplantation, while transplant ineligible patients should receive induction therapy and maintenance. The choice of treatment options depends on risk stratification and patient characteristics.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tran Kim Son, Ngo Hoang Toan, Nguyen Thang, Huynh Le Trong Tuong, Hoang Anh Tien, Nguyen Hai Thuy, Huynh Van Minh, Paul Valensi
Summary: This study investigated the prevalence of prediabetes and insulin resistance (IR) in Vietnamese patients with heart failure (HF) and no overweight, diabetes, or hypertension. The study found that HF patients had a higher prevalence of prediabetes and IR compared to healthy controls. Furthermore, prediabetes and IR were associated with a more severe HF. These findings suggest that HF may play a role in the development of IR and emphasize the importance of intervention strategies for HF patients with prediabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Peripheral Vascular Disease
Son Kim Tran, Toan Hoang Ngo, Anh Thi Phuong Nguyen, Huyen Thi Ngoc Huynh, Cuong Tan Vo, Ngan Ngoc Bao Nguyen, Thang Hoang Nguyen, Minh Van Huynh
Summary: This study investigated the impact of premature ventricular contraction (PVC) on hypertensive patients with left ventricular hypertrophy (LVH), and evaluated the effectiveness of bisoprolol in treating PVC in Vietnamese patients with hypertension. The results showed that low-dose bisoprolol effectively reduced the number of PVCs in hypertensive patients with LVH.
CURRENT HYPERTENSION REVIEWS
(2023)
Article
Respiratory System
Khanh Hoang Pham, Nhung Thi Cam Tran, Hung Do Tran, Toan Hoang Ngo, Van De Tran, Hung Huynh Vinh Ly, Nga Thi Ngoc Pham, Thang Nguyen, Binh Huy Nguyen, Kien Trung Nguyen
Summary: This study found an association between the genetic variant SNP FAM13A-rs17014601 and the risk of COPD through genetic testing of COPD patients and non-COPD patients. The TT homozygous genotype has a lower risk of COPD compared to other genotypes. Therefore, rs17014601 may be a genetic factor in the development of COPD.
ADVANCES IN RESPIRATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Son Kim Tran, Toan Hoang Ngo, Tin Trung Lai, Giang Khanh Truong, Khoa Dang Dang Tran, Phuong Minh Vo, Phi The Nguyen, Phi Hoang Nguyen, Thuan Tuan Nguyen, Oanh Thi Kim Nguyen, Thang Nguyen, Kien Trung Nguyen, Hung Do Tran
Summary: This study aimed to determine the factors associated with changes in galectin-3 levels in heart failure patients after 12 weeks of spironolactone treatment. The results showed that treatment with spironolactone significantly reduced galectin-3 concentrations, especially at a dose of 50 mg once daily.
Article
Health Care Sciences & Services
Son Kim Tran, Toan Hoang Ngo, Phi Hoang Nguyen, An Bao Truong, Giang Khanh Truong, Khoa Dang Dang Tran, Phuong Minh Vo, Phi The Nguyen, Thuan Tuan Nguyen, Phu Ngoc Thien Nguyen, Kien Trung Nguyen, Hung Do Tran
Summary: This study investigated the prevalence of hyperhomocysteinemia and its associated factors in newly diagnosed primary hypertension patients. The results showed that elevated blood total homocysteine levels were common in these patients and often correlated with age, gender, hypertension stage, and diabetes.
Article
Peripheral Vascular Disease
Toan Hoang Ngo, Nha Tran Khuong Nguyen, Nga Thi Ngoc Pham, Bao Lam Thai Tran, An Tuan Huynh, Khue Duy Nguyen, Khuong Duy Nguyen, An Viet Tran
Summary: The combination of CYP2C19 gene polymorphism and inflammatory cell ratios is a significant factor in the prognosis of coronary heart disease. The combination of NLR, PLR, or MLR with CYP2C19 gene polymorphism is a stronger predictor of cardiovascular events in patients with acute coronary syndrome.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2023)
Article
Pharmacology & Pharmacy
A. -V. Tran, K. -D. Nguyen, K. -D. Nguyen, A. -T. Huynh, B. -L. -T. Tran, T. -H. Ngo
Summary: This study demonstrated the predictive performance of CHA2DS2-VASc-HS scores and Framingham risk scores in determining coronary artery injury. These scores could be used to predict asymptomatic cases of coronary artery disease where invasive coronary angiography is not indicated.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
An Viet Tran, Nguyet Minh Nguyen, Toan Hoang Ngo, Bao Lam Thai Tran, Phong Thanh Pham, Hieu Minh Trinh Phan, Phuong Minh Nguyen
Summary: This study demonstrates that 128-slice CCTA has high sensitivity and positive predictive value for diagnosing coronary artery disease, particularly in the patient-based model. However, these values are lower in the vessel-based and segment-based models. An increase in the calcium score decreases the diagnostic performance.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)