Article
Sociology
Alex Broom, Sophie Lewis, Rhiannon Parker, Leah Williams Veazey, Katherine Kenny, Emma Kirby, Renata Kokanovic, Zarnie Lwin, Eng-Siew Koh
Summary: Understanding the complex personhood of migrants living with cancer is crucial for informing care practices. Social science theories help illuminate the intersecting themes between personhood and care, emphasizing forms of difference, vulnerability, and otherness.
SOCIOLOGICAL REVIEW
(2021)
Article
Immunology
Neda Soleimani, Mahtab Moshref Javadi
Summary: Cancer, a significant challenge in health and medicine, has treatments with negative effects and drug resistance issues. Bacterial therapy for cancer has shown promise in lysing tumor cells and delivering therapeutic products, but also faces challenges of potential harm to healthy tissues and genetic mutations.
MICROBIAL PATHOGENESIS
(2022)
Article
Medicine, General & Internal
Grazia Pertile, Daniela Iacovello, Giorgia Maraone, Elisa Bottega, Massimo Guerriero, Emilia Maggio
Summary: The purpose of this study was to investigate the morpho-functional changes after surgical treatment for ERM foveoschisis or lamellar macular hole (LMH), and to evaluate if the two entities are associated with different healing processes and long-term outcomes. The results showed that there was progressive improvement in best-corrected visual acuity (BCVA) after surgery, with no significant difference between the two groups. An increased number of eyes with intact outer-retinal layers were found in both the ERM foveoschisis and LMH groups. Autofluorescence (FAF) diameter and area decreased significantly throughout the follow-up, with no significant difference between the two groups.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, Research & Experimental
Lanlan Zhang, Jianlong Wu, Ziguan Zhu, Yuchen He, Renpeng Fang
Summary: Aging is a natural process characterized by physical decline and increased vulnerability to death. Despite efforts to understand and delay aging, limited progress has been made in the field of anti-aging. Recent studies have focused on the role of mitochondrial dysfunction in aging and related degenerative diseases, suggesting that restoring mitochondrial function can promote healthy aging. This paper provides an overview of mitochondrial changes during aging and summarizes advanced studies on mitochondrial therapies for degenerative diseases, offering novel directions for future research.
Review
Cell Biology
Kai Sun, Xingzhi Jing, Jiachao Guo, Xudong Yao, Fengjing Guo
Summary: Mitochondrial dysfunction is crucial in the development of intervertebral disc degeneration and osteoarthritis. Targeting mitophagy pathways may offer promising therapeutic strategies for degenerative joint diseases.
Review
Medicine, General & Internal
Denise O'Connor, Renea Johnston, Romina Brignardello-Petersen, Rudolf W. Poolman, Sheila Cyril, Per O. Vandvik, Rachelle Buchbinder
Summary: Arthroscopic knee surgery shows minimal to no clinically important benefit in pain or function, probably does not provide significant improvement in knee-specific quality of life, and may not enhance treatment success compared to placebo surgery. The evidence also suggests that serious and total adverse events may not differ significantly or may slightly increase with arthroscopic surgery, but the certainty of this evidence is low. The impact of arthroscopic surgery on subsequent knee surgery compared to control remains uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Lacramioara Samoila, Oliviu Vostinaru, Elena Dinte, Andreea Elena Bodoki, Bogdan-Cezar Iacob, Ede Bodoki, Ovidiu Samoila
Summary: The topical administration of medicines for retinal degenerative diseases is limited by the eye's barriers, but NSAIDs have shown potential for effective treatment. Other drug classes may require fine-tuning of pharmacokinetic profiles or advanced formulation strategies for improved delivery to the retina. Ultimately, developing more effective ways of delivering drugs to the posterior eye will enhance clinical efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Leonard J. Hoenig
Summary: This article introduces Solomon Ibn Gabirol, a medieval Jewish poet and philosopher, who depicts his distressing skin disorder through poetry, using fantastic and grotesque imagery from the Bible. It highlights the immense human suffering and misery that can result from skin diseases.
CLINICS IN DERMATOLOGY
(2022)
Review
Cell Biology
Min Xiang, Ling Liu, Tingrui Wu, Bo Wei, Huan Liu
Summary: RNA-binding proteins (RBPs), which consist of multiple intermediate sequences, play important roles in various biological functions by interacting with proteins, mRNA, and non-coding RNAs. This article focuses on the functions of RBPs in degenerative joint diseases (IVDD and OA) and reviews the latest advancements in understanding the regulatory mechanisms of RBPs. It provides a novel perspective on the pathophysiology, early diagnosis, and treatment of OA and IVDD.
AGEING RESEARCH REVIEWS
(2023)
Article
Multidisciplinary Sciences
Ryuichi Koga, Masahiko Tanahashi, Naruo Nikoh, Takahiro Hosokawa, Xian-Ying Meng, Minoru Moriyama, Takema Fukatsu
Summary: Microbial symbioses play a significant role in diverse organisms, with long-lasting associations leading to symbiont genome erosion and potential extinction. The discovery of a host protein essential for sustaining symbiosis in Plataspid stinkbugs sheds light on how intimate host-symbiont associations can be maintained over evolutionary time. In addition to the host's guardian protein, the symbiont's molecular chaperone, GroEL, is overproduced in capsules, compensating for the symbiont's eroding functionality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Michael Stern, James A. McNew
Summary: The study discusses the changes in signaling pathways and their impact on cell degeneration in neurodegenerative and muscle degeneration disorders. It was found that TOR kinase and AMPK show reciprocal changes in activity during degeneration, and oxidative stress response may be a key factor in degeneration.
MOLECULAR PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Huafeng Wang, Fengfei Lin, Guiqing Liang, Boling Liu, Yuhan Lin
Summary: This report describes a rare case of thoracic degenerative spondylolisthesis involving only the lower thoracic region. The patient underwent posterior decompression with TTIF and showed good recovery postoperatively, with follow-up MRI confirming successful spinal cord decompression and improvement in signal intensity.
Review
Chemistry, Multidisciplinary
Pengbin Yin, Yuheng Jiang, Xuan Fang, Daofeng Wang, Yi Li, Ming Chen, Hao Deng, Peifu Tang, Licheng Zhang
Summary: Degenerative musculoskeletal diseases (DMDs) present significant challenges in the aging population, with limited strategies for regeneration and repair. Cell-based therapies have shown promising effects in DMDs due to their unique mechanisms of action. This review highlights current experimental attempts, generalizes the modes of action of different cell types and their derivatives, reviews state-of-the-art clinical trials, summarizes approaches to improve therapy efficiency, and identifies unresolved questions and potential research directions.
Review
Immunology
Sean K. Wang, Constance L. Cepko
Summary: This review discusses the roles of microglia in various eye disorders and explores the potential of targeting microglia for disease treatment. Different approaches include depleting microglia, reprogramming microglia, and inhibiting their downstream effects. Future research is needed to fully utilize the therapeutic value of microglia in eye diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Christian Blume, M. F. Geiger, M. Mueller, H. Clusmann, V Mainz, J. Kalder, L. O. Brandenburg, C. A. Mueller
Summary: Patients with degenerative cervical myelopathy (DCM) show altered levels of angiogenic and inflammatory mediators, along with mild to moderate blood-spinal cord barrier disruption. This could contribute to the pathogenesis of DCM and secondary harm to the spinal cord.
SCIENTIFIC REPORTS
(2021)