Article
Biochemistry & Molecular Biology
Atsuhiko Okura, Koichi Inoue, Eisuke Sakuma, Hiroshi Takase, Takatoshi Ueki, Mitsuhito Mase
Summary: Schwann cells are crucial for peripheral myelination and the activation of the SGK1 signaling pathway plays a significant role in determining cell fate during nerve injury and repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Neurosciences
Fang Cheng Wong, Linhan Ye, Ihsan Ekin Demir, Christoph Kahlert
Summary: This review discusses the role of Schwann cell-derived exosomes in the regenerative potential and pathological processes of the peripheral nervous system, highlighting their potential applications as delivery vehicles for therapeutics and biomarkers. The research emphasizes the crucial role of SC-derived exosomes in the functional integration of the PNS, pointing to an emerging area with much to explore and re-explore.
Article
Engineering, Biomedical
Wen-Yuan Li, Zhi-Gang Li, Xiu-Mei Fu, Xiao-yu Wang, Zhong-xiao Lv, Ping Sun, Xiao-Feng Zhu, Ying Wang
Summary: This study identifies POU6F1 as a novel regulator of post-injury sciatic nerve repair, acting through JNK/c-Jun signaling in SCs to optimize therapeutic outcomes in the ANA surgical approach.
JOURNAL OF NEURAL ENGINEERING
(2022)
Review
Neurosciences
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Zhong-Ya Wei
Summary: Peripheral neuropathy is a common neurological issue with limited treatment options. Schwann cell transplantation plays a crucial role in resolving peripheral neuropathy, and stem cells have the potential to differentiate into Schwann-like cells. These studies provide insights into cell therapy and uncover prospective therapeutic strategies for peripheral neuropathy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Cristian Saquel, Romina J. Catalan, Rodrigo Lopez-Leal, Ramon A. Ramirez, David Necunir, Ursula Wyneken, Christophe Lamaze, Felipe A. Court
Summary: Functional recovery after peripheral nerve injuries relies on axonal regeneration, which is regulated by both autonomous and non-cell autonomous processes. This study demonstrates that neuronal activity enhances the release of repair Schwann cell-derived extracellular vesicles (EVs) and their transfer to neurons. This effect is mediated by the ATP-P2Y signaling pathway and leads to increased content of miRNA-21 in the EVs. These findings highlight the importance of neuron to glia communication in regulating axonal elongation through the transfer of EVs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
David Gonzalez, Miguel L. Allende
Summary: Wallerian degeneration is a genetically conserved mechanism where peripheral nervous system axons have a higher capacity to regenerate. The use of zebrafish larvae and time-lapse microscopy allows for monitoring of the regenerative process of peripheral nerves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Tianhao Yu, Yingxi Xu, Muhammad Arslan Ahmad, Rabia Javed, Haruo Hagiwara, Xiaohong Tian
Summary: Autologous nerve grafts are widely accepted as the gold standard for peripheral nerve repair, but their usability is reduced by inherent drawbacks. Exosomes, as key players in intercellular communication, have shown promising potential in treating peripheral nerve injury and enhancing the repairing capacity of nerve grafts.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yizhu Shan, Lingling Xu, Xi Cui, Engui Wang, Fengying Jiang, Jiaxuan Li, Han Ouyang, Tailang Yin, Hongqing Feng, Dan Luo, Yan Zhang, Zhou Li
Summary: A responsive cascade drug delivery scaffold (RCDDS) has been developed to dynamically adjust drug release kinetics based on the patient's condition, promoting the treatment of peripheral nerve injury.
MATERIALS HORIZONS
(2023)
Article
Biochemistry & Molecular Biology
Ahad M. Siddiqui, Rosa Brunner, Gregory M. Harris, Alan Lee Miller, Brian E. Waletzki, Ann M. Schmeichel, Jean E. Schwarzbauer, Jeffrey Schwartz, Michael J. Yaszemski, Anthony J. Windebank, Nicolas N. Madigan
Summary: Spinal cord injury leads to cell death and axonal loss, and current clinical therapies are ineffective. Researchers have developed a novel scaffold biomaterial that may promote neural regeneration, offering potential for SCI treatment.
Review
Neurosciences
Kristjan R. Jessen, Rhona Mirsky
Summary: After nerve injury, both Schwann cells and neurons switch to pro-regenerative states. However, the poor functional repair cell phenotype is an important reason for the poor outcomes after nerve damage.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Andres Fuentes-Flores, Cristian Geronimo-Olvera, Karina Girardi, David Necunir-Ibarra, Sandip Kumar Patel, Joanna Bons, Megan C. Wright, Daniel Geschwind, Ahmet Hoke, Jose A. Gomez-Sanchez, Birgit Schilling, Daniela L. Rebolledo, Judith Campisi, Felipe A. Court
Summary: Reparative Schwann cells transition into a senescent phenotype in aging and chronic denervation, leading to inhibition of axonal regeneration. Elimination of senescent cells improves nerve regeneration and functional recovery.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biology
Tian-Kun Hui, Xin-Sheng Lai, Xia Dong, Hongyang Jing, Ziyang Liu, Erkang Fei, Wen-Bing Chen, Shunqi Wang, Dongyan Ren, Suqi Zou, Hai-Tao Wu, Bing-Xing Pan
Summary: Schwann cells play a crucial role in peripheral nerve regeneration, while the conditional knockout of Lrp4 in SCs contributes to enhanced nerve regeneration by promoting SC proliferation and myelin debris clearance. These results suggest a novel role for Lrp4 in peripheral nerve recovery and provide a potential therapeutic target.
Review
Neurosciences
Frederic A. A. Vallejo, Anthony Diaz, Emily L. L. Errante, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. E. Brooks, Yee-Shuan Lee, Stephen Shelby Burks, Allan D. D. Levi
Summary: This study systematically evaluated the therapeutic use of Schwann cells (SC) in the repair of peripheral nerve injuries. The results showed that SCs have clear potential in improving morphological and functional outcomes in animal studies of long gap peripheral nerve injuries. However, the optimal nerve conduit or graft for delivering and retaining SCs for nerve regeneration has yet to be determined.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Meng-Ju Lin, Chia-Ming Lee, Wei-Lin Hsu, Bi-Chang Chen, Shyh-Jye Lee
Summary: Macrophages may physically alleviate nerve inhibition and promote regeneration and development in the zebrafish lateral line.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carina Hromada, Jaana Hartmann, Johannes Oesterreicher, Anton Stoiber, Anna Daerr, Barbara Schaedl, Eleni Priglinger, Andreas H. Teuschl-Woller, Wolfgang Holnthoner, Johannes Heinzel, David Hercher
Summary: This study reveals increased lymphangiogenesis after peripheral nerve injury and repair. The findings suggest that Schwann cells may have an inhibitory effect on lymphatic vessel formation.