Article
Plant Sciences
Rui Shi, Sheri P. Kernodle, Tyler M. Steede, Ramsey S. Lewis
Summary: Nitrogen physiology plays an important role in tobacco growth and yield, and the mutant genes Yb-1 and Yb-2 may have negative effects on nitrogen utilization and alkaloid levels. Overexpression of the Yb-1 gene can benefit mutant genotypes but not wild-type genotypes. Transcriptome analysis reveals that altered expression of Yb-1 can affect metabolic pathways related to carbon and nitrogen metabolism.
Article
Endocrinology & Metabolism
Inge Van Vaerenbergh, Tom Adriaenssens, Wim Coucke, Lisbet Van Landuyt, Greta Verheyen, Michael De Brucker, Michel Camus, Peter Platteau, Michel De Vos, Elien Van Hecke, Andre Rosenthal, Johan Smitz
Summary: The study confirmed the clinical benefits of analyzing the gene expression profile of three predictive genes in cumulus cells for improving the pregnancy and live birth rates in IVF patients. Additionally, the study found that the time-to-pregnancy could be significantly shortened by using the cumulus cell test, regardless of the number of transferable embryos on Day 3.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Maysa E. Moharam, Magda A. El-Bendary, Mostafa M. Abo Elsoud, Fawkia El- Beih, Saadia M. Hassnin, Abeer Salama, Enayat A. Omara, Nora N. Elgamal
Summary: The formation of blood clots increases the risk of heart attacks and strokes, necessitating research in the treatment and prevention of these conditions. One approach is the use of microbial-produced fibrinolytic enzymes as thrombolytic agents. This study utilized Bacillus subtilis Egy for enzyme production under solid-state fermentation and optimized the production conditions. The produced fibrinolytic enzyme showed no cytotoxicity in vitro and in vivo, making it a promising treatment option for blood clots.
Article
Cell Biology
Rosari Hernandez-Vicens, Jagreeti Singh, Nomi Pernicone, Tamar Listovsky, Gabi Gerlitz
Summary: Our study suggests that SETDB1 affects microtubule dynamics by interacting with both microtubules and HDAC6 to enhance tubulin deacetylation. These findings provide a novel insight into the cytoplasmic role of SETDB1 in the regulation of microtubule dynamics.
CELL PROLIFERATION
(2022)
Article
Biochemistry & Molecular Biology
Shuhei Ueshima, Jia Fang
Summary: The study investigates the pro-metastasis activity of the key epigenetic regulator SETDB1 in non-small cell lung cancer (NSCLC). It demonstrates that SETDB1 enhances the migration and invasion capabilities of NSCLC cells by reinforcing invadopodia formation and facilitating ECM degradation. The molecular mechanism reveals that SETDB1 suppresses the expression of the tumor and metastasis suppressor FOXA2 through coordinated epigenetic mechanisms.
Article
Medicine, General & Internal
Dalma Noemi Nagy, Tamas Fazekas, Kornelia Baghy, Gergo Papp, Anita Csizmarik, Miklos Szucs, Peter Nyirady, Tibor Szarvas
Summary: BRCA1/2 deficient prostate cancers, a clinically distinct aggressive subtype, demonstrate enhanced sensitivity to platinum-based chemotherapies. Although the efficacy of platinum-based chemotherapies in prostate cancer has not been proven, this case of BRCA2 mutant prostate cancer highlights significant response to carboplatin chemotherapy.
Article
Oncology
Junling Huang, Tengmeng Zhong, Guangzhi Li, Shuzhen Wang, Rujuan Qin
Summary: The lncRNA GMDS-AS1 acts as a tumor suppressor in hepatocellular carcinoma (HCC) and is regulated by ESET through epigenetic mechanisms. The downstream target gene PSMB1 promotes tumor proliferation and is negatively regulated by GMDS-AS1.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Kakuja Flora, Palasti Peter, Oroszi Marton, Kuthi Levente, Kiraly Istvan Elod, Kincses Zsigmond Tamas, Palko Andras, Fejes Zsuzsanna
Summary: Ultrasonography is essential for evaluating testicular structures, especially in differential diagnosis and rare paratesticular abnormalities. Knowledge of frequent abnormalities and corresponding ultrasound findings is important for treatment planning.
Article
Cardiac & Cardiovascular Systems
Hesham Bahaa, Yasser Sadek, Ahmad E. Mostafa, Diaa Kamal, Mahmoud Baraka, Mohammad Abdelghani, Ahmed Hassan, Ahmed Shehata, Magdy Abdelhamid, Ahmed Elguindy
Summary: The study found that the outcomes of TAVI in Egypt were very promising, with mortality and complication rates comparable to international registries, indicating the procedure is safe and beneficial. Establishing a national registry is crucial in highlighting strengths and weaknesses and identifying key areas for improvement.
EGYPTIAN HEART JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Hatem M. Abuohashish, Amany S. El Sharkawy
Summary: This study successfully isolated a characteristic blue pyocyanin compound from a marine pseudomonas strain and characterized its antimicrobial activity. The marine-isolated P. otitidis represents a promising new source of marine-derived pyocyanin, which has antimicrobial efficacy mainly against Gram-positive pathogens.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2023)
Editorial Material
Biology
Sahana Sitaraman
Summary: Facing compulsions and obsessive thoughts, a graduate student finds inner strength by embracing her identity as a scientist.
Article
Multidisciplinary Sciences
Dandan Wang, Lingfang Zhu, Xiangkai Zhen, Daoyan Yang, Changfu Li, Yating Chen, Huannan Wang, Yichen Qu, Xiaozhen Liu, Yanling Yin, Huawei Gu, Lei Xu, Chuanxing Wan, Yao Wang, Songying Ouyang, Xihui Shen
Summary: Bacteria have developed a secretion system to deliver effector proteins into neighboring cells, but the functions of many effectors are still unknown. In this study, the researchers identified an effector called CccR secreted by Yersinia pseudotuberculosis that can act as both a toxin and a transcription factor. CccR can enter nearby cells of the same and other species, and modulate gene expression and inhibit the growth of competitors.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Xin Shi, Anna-Katharina Pumm, Christopher Maffeo, Fabian Kohler, Elija Feigl, Wenxuan Zhao, Daniel Verschueren, Ramin Golestanian, Aleksei Aksimentiev, Hendrik Dietz, Cees Dekker
Summary: In this study, we experimentally demonstrate the feasibility of developing functional synthetic turbines at the nanoscale by rationally designing nanoscale DNA origami turbines. These turbines can utilize transmembrane electrochemical potentials to rotate autonomously and operate in physiological conditions. This research opens new possibilities for engineering active robotics at the nanoscale.
NATURE NANOTECHNOLOGY
(2023)
Editorial Material
Biology
Jeffrey E. Markowitz
Summary: By mapping neural activity, it has been found that striatal cells in the deep brain represent important aspects of self-grooming behavior.
Editorial Material
Biology
Danelle Devenport
Summary: This article discusses the use of advanced imaging techniques to reveal the details of interactions between the two layers of the embryonic midgut that influence its final shape.
